SARS-COV-2 spike binding to ACE2 in living cells monitored by TR-FRET

por Cecon, Erika, Burridge, Matilda, Cao, Longxing, Carter, Lauren, Ravichandran, Rashmi, Dam, Julie, Jockers, Ralf
Publicado 2022

Hierarchical design of pseudosymmetric protein nanoparticles

por Dowling, Quinton M., Park, Young-Jun, Gerstenmaier, Neil, Yang, Erin C., Wargacki, Adam, Hsia, Yang, Fries, Chelsea N., Ravichandran, Rashmi, Walkey, Carl, Burrell, Anika, Veesler, David, Baker, David, King, Neil P.
Publicado 2023

Hierarchical design of pseudosymmetric protein nanoparticles

por Dowling, Quinton M., Park, Young-Jun, Gerstenmaier, Neil, Yang, Erin C., Wargacki, Adam, Hsia, Yang, Fries, Chelsea N., Ravichandran, Rashmi, Walkey, Carl, Burrell, Anika, Veesler, David, Baker, David, King, Neil P.
Publicado 2023

Design of a hyperstable 60-subunit protein icosahedron

por Hsia, Yang, Bale, Jacob B., Gonen, Shane, Shi, Dan, Sheffler, William, Fong, Kimberly K., Nattermann, Una, Xu, Chunfu, Huang, Po-Ssu, Ravichandran, Rashmi, Yi, Sue, Davis, Trisha N., Gonen, Tamir, King, Neil P., Baker, David
Publicado 2016

Ultrapotent miniproteins targeting the receptor-binding domain protect against SARS-CoV-2 infection and disease in mice

por Case, James Brett, Chen, Rita E., Cao, Longxing, Ying, Baoling, Winkler, Emma S., Goreshnik, Inna, Shrihari, Swathi, Kafai, Natasha M., Bailey, Adam L., Xie, Xuping, Shi, Pei-Yong, Ravichandran, Rashmi, Carter, Lauren, Stewart, Lance, Baker, David, Diamond, Michael S.
Publicado 2021

Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease

por Case, James Brett, Chen, Rita E., Cao, Longxing, Ying, Baoling, Winkler, Emma S., Johnson, Max, Goreshnik, Inna, Pham, Minh N., Shrihari, Swathi, Kafai, Natasha M., Bailey, Adam L., Xie, Xuping, Shi, Pei-Yong, Ravichandran, Rashmi, Carter, Lauren, Stewart, Lance, Baker, David, Diamond, Michael S.
Publicado 2021

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy

por Quijano-Rubio, Alfredo, Bhuiyan, Aladdin M., Yang, Huilin, Leung, Isabel, Bello, Elisa, Ali, Lestat R., Zhangxu, Kevin, Perkins, Jilliane, Chun, Jung-Ho, Wang, Wentao, Lajoie, Marc J., Ravichandran, Rashmi, Kuo, Yun-Huai, Dougan, Stephanie K., Riddell, Stanley R., Spangler, Jamie B., Dougan, Michael, Silva, Daniel-Adriano, Baker, David
Publicado 2022

Process development of a SARS-CoV-2 nanoparticle vaccine

por Martinez-Cano, Diandra, Ravichandran, Rashmi, Le, Huong, Wong, H. Edward, Jagannathan, Bharat, Liu, Erik J., Bailey, William, Yang, Jane, Matthies, Kelli, Barkhordarian, Hedieh, Shah, Bhavana, Srinivasan, Nithya, Zhang, Jun, Hsu, Angel, Wypych, Jette, Stevens, Jennitte, Piedmonte, Deirdre Murphy, Miranda, Les P., Carter, Lauren, Murphy, Michael, King, Neil P., Soice, Neil
Publicado 2023

Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate

por Sliepen, Kwinten, Radić, Laura, Capella-Pujol, Joan, Watanabe, Yasunori, Zon, Ian, Chumbe, Ana, Lee, Wen-Hsin, de Gast, Marlon, Koopsen, Jelle, Koekkoek, Sylvie, del Moral-Sánchez, Iván, Brouwer, Philip J. M., Ravichandran, Rashmi, Ozorowski, Gabriel, King, Neil P., Ward, Andrew B., van Gils, Marit J., Crispin, Max, Schinkel, Janke, Sanders, Rogier W.
Publicado 2022

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

por Marcandalli, Jessica, Fiala, Brooke, Ols, Sebastian, Perotti, Michela, de van der Schueren, Willem, Snijder, Joost, Hodge, Edgar, Benhaim, Mark, Ravichandran, Rashmi, Carter, Lauren, Sheffler, Will, Brunner, Livia, Lawrenz, Maria, Dubois, Patrice, Lanzavecchia, Antonio, Sallusto, Federica, Lee, Kelly K., Veesler, David, Correnti, Colin E., Stewart, Lance J., Baker, David, Loré, Karin, Perez, Laurent, King, Neil P.
Publicado 2019

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

por Brouwer, Philip J. M., Antanasijevic, Aleksandar, de Gast, Marlon, Allen, Joel D., Bijl, Tom P. L., Yasmeen, Anila, Ravichandran, Rashmi, Burger, Judith A., Ozorowski, Gabriel, Torres, Jonathan L., LaBranche, Celia, Montefiori, David C., Ringe, Rajesh P., van Gils, Marit J., Moore, John P., Klasse, Per Johan, Crispin, Max, King, Neil P., Ward, Andrew B., Sanders, Rogier W.
Publicado 2021

Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses

por Brinkkemper, Mitch, Veth, Tim S., Brouwer, Philip J.M., Turner, Hannah, Poniman, Meliawati, Burger, Judith A., Bouhuijs, Joey H., Olijhoek, Wouter, Bontjer, Ilja, Snitselaar, Jonne L., Caniels, Tom G., van der Linden, Cynthia A., Ravichandran, Rashmi, Villaudy, Julien, van der Velden, Yme U., Sliepen, Kwinten, van Gils, Marit J., Ward, Andrew B., King, Neil P., Heck, Albert J.R., Sanders, Rogier W.
Publicado 2022

Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design

por Ellis, Daniel, Brunette, Natalie, Crawford, Katharine H. D., Walls, Alexandra C., Pham, Minh N., Chen, Chengbo, Herpoldt, Karla-Luise, Fiala, Brooke, Murphy, Michael, Pettie, Deleah, Kraft, John C., Malone, Keara D., Navarro, Mary Jane, Ogohara, Cassandra, Kepl, Elizabeth, Ravichandran, Rashmi, Sydeman, Claire, Ahlrichs, Maggie, Johnson, Max, Blackstone, Alyssa, Carter, Lauren, Starr, Tyler N., Greaney, Allison J., Lee, Kelly K., Veesler, David, Bloom, Jesse D., King, Neil P.
Publicado 2021

Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants

por Zhang, Jason Z., Yeh, Hsien-Wei, Walls, Alexandra C., Wicky, Basile I. M., Sprouse, Kaitlin R., VanBlargan, Laura A., Treger, Rebecca, Quijano-Rubio, Alfredo, Pham, Minh N., Kraft, John C., Haydon, Ian C., Yang, Wei, DeWitt, Michelle, Bowen, John E., Chow, Cameron M., Carter, Lauren, Ravichandran, Rashmi, Wener, Mark H., Stewart, Lance, Veesler, David, Diamond, Michael S., Greninger, Alexander L., Koelle, David M., Baker, David
Publicado 2022

Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens

por Kraft, John C., Pham, Minh N., Shehata, Laila, Brinkkemper, Mitch, Boyoglu-Barnum, Seyhan, Sprouse, Kaitlin R., Walls, Alexandra C., Cheng, Suna, Murphy, Mike, Pettie, Deleah, Ahlrichs, Maggie, Sydeman, Claire, Johnson, Max, Blackstone, Alyssa, Ellis, Daniel, Ravichandran, Rashmi, Fiala, Brooke, Wrenn, Samuel, Miranda, Marcos, Sliepen, Kwinten, Brouwer, Philip J.M., Antanasijevic, Aleksandar, Veesler, David, Ward, Andrew B., Kanekiyo, Masaru, Pepper, Marion, Sanders, Rogier W., King, Neil P.
Publicado 2022

Quadrivalent influenza nanoparticle vaccines induce broad protection

por Boyoglu-Barnum, Seyhan, Ellis, Daniel, Gillespie, Rebecca A., Hutchinson, Geoffrey B., Park, Young-Jun, Moin, Syed M., Acton, Oliver J., Ravichandran, Rashmi, Murphy, Mike, Pettie, Deleah, Matheson, Nick, Carter, Lauren, Creanga, Adrian, Watson, Michael J., Kephart, Sally, Ataca, Sila, Vaile, John R., Ueda, George, Crank, Michelle C., Stewart, Lance, Lee, Kelly K., Guttman, Miklos, Baker, David, Mascola, John R., Veesler, David, Graham, Barney S., King, Neil P., Kanekiyo, Masaru
Publicado 2021

Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice

por Grigoryan, Lilit, Lee, Audrey, Walls, Alexandra C., Lai, Lilin, Franco, Benjamin, Arunachalam, Prabhu S., Feng, Yupeng, Luo, Wei, Vanderheiden, Abigail, Floyd, Katharine, Wrenn, Samuel, Pettie, Deleah, Miranda, Marcos C., Kepl, Elizabeth, Ravichandran, Rashmi, Sydeman, Claire, Brunette, Natalie, Murphy, Michael, Fiala, Brooke, Carter, Lauren, Coffman, Robert L., Novack, David, Kleanthous, Harry, O’Hagan, Derek T., van der Most, Robbert, McLellan, Jason S., Suthar, Mehul, Veesler, David, King, Neil P., Pulendran, Bali
Publicado 2022

Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses

por McLeod, Brandon, Mabrouk, Moustafa T., Miura, Kazutoyo, Ravichandran, Rashmi, Kephart, Sally, Hailemariam, Sophia, Pham, Thao P., Semesi, Anthony, Kucharska, Iga, Kundu, Prasun, Huang, Wei-Chiao, Johnson, Max, Blackstone, Alyssa, Pettie, Deleah, Murphy, Michael, Kraft, John C., Leaf, Elizabeth M., Jiao, Yang, van de Vegte-Bolmer, Marga, van Gemert, Geert-Jan, Ramjith, Jordache, King, C. Richter, MacGill, Randall S., Wu, Yimin, Lee, Kelly K., Jore, Matthijs M., King, Neil P., Lovell, Jonathan F., Julien, Jean-Philippe
Publicado 2022

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

por Walls, Alexandra C., Fiala, Brooke, Schäfer, Alexandra, Wrenn, Samuel, Pham, Minh N., Murphy, Michael, Tse, Longping V., Shehata, Laila, O’Connor, Megan A., Chen, Chengbo, Navarro, Mary Jane, Miranda, Marcos C., Pettie, Deleah, Ravichandran, Rashmi, Kraft, John C., Ogohara, Cassandra, Palser, Anne, Chalk, Sara, Lee, E-Chiang, Kepl, Elizabeth, Chow, Cameron M., Sydeman, Claire, Hodge, Edgar A., Brown, Brieann, Fuller, Jim T., Dinnon, Kenneth H., Gralinski, Lisa E., Leist, Sarah R., Gully, Kendra L., Lewis, Thomas B., Guttman, Miklos, Chu, Helen Y., Lee, Kelly K., Fuller, Deborah H., Baric, Ralph S., Kellam, Paul, Carter, Lauren, Pepper, Marion, Sheahan, Timothy P., Veesler, David, King, Neil P.
Publicado 2020

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

por Walls, Alexandra C., Miranda, Marcos C., Pham, Minh N., Schäfer, Alexandra, Greaney, Allison, Arunachalam, Prabhu S., Navarro, Mary-Jane, Tortorici, M. Alejandra, Rogers, Kenneth, O’Connor, Megan A., Shireff, Lisa, Ferrell, Douglas E., Brunette, Natalie, Kepl, Elizabeth, Bowen, John, Zepeda, Samantha K., Starr, Tyler, Hsieh, Ching-Lin, Fiala, Brooke, Wrenn, Samuel, Pettie, Deleah, Sydeman, Claire, Johnson, Max, Blackstone, Alyssa, Ravichandran, Rashmi, Ogohara, Cassandra, Carter, Lauren, Tilles, Sasha W., Rappuoli, Rino, O’Hagan, Derek T., Van Der Most, Robbert, Van Voorhis, Wesley C., McLellan, Jason S., Kleanthous, Harry, Sheahan, Timothy P., Fuller, Deborah H., Villinger, Francois, Bloom, Jesse, Pulendran, Bali, Baric, Ralph, King, Neil, Veesler, David
Publicado 2021