Synthesis of a benzoxazinthione derivative of tanaproget and pharmacological evaluation for PET imaging of PR expression

por Allott, Louis, Miranda, Cecilia, Hayes, Angela, Raynaud, Florence, Cawthorne, Christopher, Smith, Graham
Publicado 2019

A Phase I/II Study of a 72-h Continuous Infusion of Etoposide in Advanced Soft Tissue Sarcoma

por Crawley, Charles R., Judson, Ian R., Verrill, Mark, Hill, Catherine, Raynaud, Florence I.
Publicado 1997

Competitive SPR using an intracellular anti-LMO2 antibody identifies novel LMO2-interacting compounds

por Canning, Peter, Bataille, Carole, Bery, Nicolas, Milhas, Sabine, Hayes, Angela, Raynaud, Florence, Miller, Ami, Rabbitts, Terry
Publicado 2021

Effect of acute total sleep deprivation on plasma melatonin, cortisol and metabolite rhythms in females

por Honma, Aya, Revell, Victoria L., Gunn, Pippa J., Davies, Sarah K., Middleton, Benita, Raynaud, Florence I., Skene, Debra J.
Publicado 2019

Machine learning estimation of human body time using metabolomic profiling

por Woelders, Tom, Revell, Victoria L., Middleton, Benita, Ackermann, Katrin, Kayser, Manfred, Raynaud, Florence I., Skene, Debra J., Hut, Roelof A.
Publicado 2023

Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assay—Biological Implications

por Naseem, Afia, Pal, Akos, Gowan, Sharon, Asad, Yasmin, Donovan, Adam, Temesszentandrási-Ambrus, Csilla, Kis, Emese, Gaborik, Zsuzsanna, Bhalay, Gurdip, Raynaud, Florence
Publicado 2022

Identification of Human Plasma Metabolites Exhibiting Time-of-Day Variation Using an Untargeted Liquid Chromatography–Mass Spectrometry Metabolomic Approach

por Ang, Joo Ern, Revell, Victoria, Anuska, Mann, Mäntele, Simone, Otway, Daniella T., Johnston, Jonathan D., Thumser, Alfred E., Skene, Debra J., Raynaud, Florence
Publicado 2012

A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2

por Bery, Nicolas, Bataille, Carole J.R., Russell, Angela, Hayes, Angela, Raynaud, Florence, Milhas, Sabine, Anand, Sneha, Tulmin, Hanna, Miller, Ami, Rabbitts, Terence H.
Publicado 2021

Peritumoral Delivery of Docetaxel‐TIPS Microparticles for Prostate Cancer Adjuvant Therapy

por Paliashvili, Ketevan, Popov, Alexander, Kalber, Tammy L., Patrick, P. Stephen, Hayes, Angela, Henley, Alan, Raynaud, Florence I., Ahmed, Hashim U., Day, Richard M.
Publicado 2020

Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species

por Wood, Francesca L., Shepherd, Sam, Hayes, Angela, Liu, Manjuan, Grira, Katia, Mok, Yi, Atrash, Butrus, Faisal, Amir, Bavetsias, Vassilios, Linardopoulos, Spiros, Blagg, Julian, Raynaud, Florence I.
Publicado 2019

Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation

por Pal, Akos, Asad, Yasmin, Ruddle, Ruth, Henley, Alan T., Swales, Karen, Decordova, Shaun, Eccles, Suzanne A ., Collins, Ian, Garrett, Michelle D., De Bono, Johann, Banerji, Udai, Raynaud, Florence I.
Publicado 2020

Presence of human breast cancer xenograft changes the diurnal profile of amino acids in mice

por Junior, Rubens Paula, Sonehara, Nathália Martins, Jardim-Perassi, Bruna Victorasso, Pal, Akos, Asad, Yasmin, Almeida Chuffa, Luiz Gustavo, Chammas, Roger, Raynaud, Florence I., Zuccari, Debora A. P. C.
Publicado 2022

Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution

por Hayes, Angela, Mok, N. Yi, Liu, Manjuan, Thai, Ching, Henley, Alan T., Atrash, Butrus, Lanigan, Rachel M., Sejberg, Jimmy, Le Bihan, Yann-Vaï, Bavetsias, Vassilios, Blagg, Julian, Raynaud, Florence I.
Publicado 2016

Investigation of metabolites for estimating blood deposition time

por Lech, Karolina, Liu, Fan, Davies, Sarah K., Ackermann, Katrin, Ang, Joo Ern, Middleton, Benita, Revell, Victoria L., Raynaud, Florence J., Hoveijn, Igor, Hut, Roelof A., Skene, Debra J., Kayser, Manfred
Publicado 2017

Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes

por Coker, Elizabeth A., Stewart, Adam, Ozer, Bugra, Minchom, Anna, Pickard, Lisa, Ruddle, Ruth, Carreira, Suzanne, Popat, Sanjay, O'Brien, Mary, Raynaud, Florence, de Bono, Johann, Al-Lazikani, Bissan, Banerji, Udai
Publicado 2022

Synthesis and Evaluation of a 2,11‐Cembranoid‐Inspired Library

por Welford, Amanda J, Caldwell, John J., Liu, Manjuan, Richards, Meirion, Brown, Nathan, Lomas, Cara, Tizzard, Graham J., Pitak, Mateusz B., Coles, Simon J., Eccles, Suzanne A., Raynaud, Florence I., Collins, Ian
Publicado 2016

Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases

por Zhang, Chi, Stockwell, Simon R., Elbanna, May, Ketteler, Robin, Freeman, Jamie, Al-Lazikani, Bissan, Eccles, Suzanne, De Haven Brandon, Alexis, Raynaud, Florence, Hayes, Angela, Clarke, Paul A., Workman, Paul, Mittnacht, Sibylle
Publicado 2019

Correction: Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases

por Zhang, Chi, Stockwell, Simon R., Elbanna, May, Ketteler, Robin, Freeman, Jamie, Al-Lazikani, Bissan, Eccles, Suzanne, De Haven Brandon, Alexis, Raynaud, Florence, Hayes, Angela, Clarke, Paul A., Workman, Paul, Mittnacht, Sibylle
Publicado 2020

A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity

por Kostaras, Eleftherios, Kaserer, Teresa, Lazaro, Glorianne, Heuss, Sara Farrah, Hussain, Aasia, Casado, Pedro, Hayes, Angela, Yandim, Cihangir, Palaskas, Nicolaos, Yu, Yi, Schwartz, Brian, Raynaud, Florence, Chung, Yuen-Li, Cutillas, Pedro R., Vivanco, Igor
Publicado 2020

Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B

por Drouin, Ludovic, McGrath, Sally, Vidler, Lewis R., Chaikuad, Apirat, Monteiro, Octovia, Tallant, Cynthia, Philpott, Martin, Rogers, Catherine, Fedorov, Oleg, Liu, Manjuan, Akhtar, Wasim, Hayes, Angela, Raynaud, Florence, Müller, Susanne, Knapp, Stefan, Hoelder, Swen
Publicado 2015