Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation

por Fisher, Gemma, Corbella, Marina, Alphey, Magnus S., Nicholson, John, Read, Benjamin J., Kamerlin, Shina C. L., da Silva, Rafael G.
Publicado 2022

Catalytic Cycle of the Bifunctional Enzyme Phosphoribosyl-ATP Pyrophosphohydrolase/Phosphoribosyl-AMP Cyclohydrolase

por Fisher, Gemma, Pečaver, Ennio, Read, Benjamin J., Leese, Susannah K., Laing, Erin, Dickson, Alison L., Czekster, Clarissa M., da Silva, Rafael G.
Publicado 2023

Dissecting the Mechanism of (R)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry

por Machado, Teresa F. G., Purg, Miha, McMahon, Stephen A., Read, Benjamin J., Oehler, Verena, Åqvist, Johan, Gloster, Tracey M., da Silva, Rafael G.
Publicado 2020

Role of nanoscale antigen organization on B-cell activation probed using DNA origami

por Veneziano, Rémi, Moyer, Tyson J., Stone, Matthew B., Wamhoff, Eike-Christian, Read, Benjamin J., Mukherjee, Sayak, Shepherd, Tyson R., Das, Jayajit, Schief, William R., Irvine, Darrell J., Bathe, Mark
Publicado 2020

Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens

por Read, Benjamin J., Won, Lori, Kraft, John C., Sappington, Isaac, Aung, Aereas, Wu, Shengwei, Bals, Julia, Chen, Chengbo, Lee, Kelly K., Lingwood, Daniel, King, Neil P., Irvine, Darrell J.
Publicado 2022

Co‐Anchoring of Engineered Immunogen and Immunostimulatory Cytokines to Alum Promotes Enhanced‐Humoral Immunity

por Chang, Jason Y. H., Agarwal, Yash, Rodrigues, Kristen A., Momin, Noor, Ni, Kaiyuan, Read, Benjamin J., Moyer, Tyson J., Mehta, Naveen K., Silva, Murillo, Suh, Heikyung, Melo, Mariane B., Wittrup, K. Dane, Irvine, Darrell J.
Publicado 2022