Bespoke Drug Discovery Training for Low-Middle Income Countries

por Webster, Lauren A., Farrell, Susan J., Gilbert, Ian H., Read, Kevin D.
Publicado 2023

Target Validation: Linking Target and Chemical Properties to Desired Product Profile

por Wyatt, Paul G, Gilbert, Ian H, Read, Kevin D, Fairlamb, Alan H
Publicado 2011

Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease

por Riley, Jennifer, Brand, Stephen, Voice, Michael, Caballero, Ivan, Calvo, David, Read, Kevin D.
Publicado 2015

Anti-trypanosomatid drug discovery: progress and challenges

por De Rycker, Manu, Wyllie, Susan, Horn, David, Read, Kevin D., Gilbert, Ian H.
Publicado 2022

Temporal and Wash-Out Studies Identify Medicines for Malaria Venture Pathogen Box Compounds with Fast-Acting Activity against Both Trypanosoma cruzi and Trypanosoma brucei

por Sykes, Melissa L., Kennedy, Emily K., Read, Kevin D., Kaiser, Marcel, Avery, Vicky M.
Publicado 2022

Correction to “Bespoke Drug Discovery Training for Low-Middle Income Countries”

por Webster, Lauren A., Farrell, Susan J., Gilbert, Ian H., Wyatt, Paul G., Read, Kevin D.
Publicado 2023

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

por Jones, Deuan C., Hallyburton, Irene, Stojanovski, Laste, Read, Kevin D., Frearson, Julie A., Fairlamb, Alan H.
Publicado 2010

Skin-Targeted Inhibition of PPAR β/δ by Selective Antagonists to Treat PPAR β/δ – Mediated Psoriasis-Like Skin Disease In Vivo

por Hack, Katrin, Reilly, Louise, Palmer, Colin, Read, Kevin D., Norval, Suzanne, Kime, Robert, Booth, Kally, Foerster, John
Publicado 2012

Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

por Dorfmueller, Helge C., Borodkin, Vladimir S., Schimpl, Marianne, Zheng, Xiaowei, Kime, Robert, Read, Kevin D., van Aalten, Daan M.F.
Publicado 2010

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S...

por Soares, Pedro, Gadd, Morgan S., Frost, Julianty, Galdeano, Carles, Ellis, Lucy, Epemolu, Ola, Rocha, Sonia, Read, Kevin D., Ciulli, Alessio
Publicado 2017

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future

por Smith, Paul W., Zuccotto, Fabio, Bates, Robert H., Martinez-Martinez, Maria Santos, Read, Kevin D., Peet, Caroline, Epemolu, Ola
Publicado 2018

Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds

por Ruda, Gian Filippo, Wong, Pui Ee, Alibu, Vincent P., Norval, Suzanne, Read, Kevin D., Barrett, Michael P., Gilbert, Ian H.
Publicado 2010

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

por Wyllie, Susan, Roberts, Adam J., Norval, Suzanne, Patterson, Stephen, Foth, Bernardo J., Berriman, Matthew, Read, Kevin D., Fairlamb, Alan H.
Publicado 2016

A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on t...

por Brandon, Andrew M., Antonides, Lysbeth H., Riley, Jennifer, Epemolu, Ola, McKeown, Denise A., Read, Kevin D., McKenzie, Craig
Publicado 2021

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

por Patterson, Stephen, Wyllie, Susan, Norval, Suzanne, Stojanovski, Laste, Simeons, Frederick RC, Auer, Jennifer L, Osuna-Cabello, Maria, Read, Kevin D, Fairlamb, Alan H
Publicado 2016

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

por Spinks, Daniel, Torrie, Leah S, Thompson, Stephen, Harrison, Justin R, Frearson, Julie A, Read, Kevin D, Fairlamb, Alan H, Wyatt, Paul G, Gilbert, Ian H
Publicado 2012

Structure–Activity Relationship Studies of Pyrrolone Antimalarial Agents

por Murugesan, Dinakaran, Kaiser, Marcel, White, Karen L, Norval, Suzanne, Riley, Jennifer, Wyatt, Paul G, Charman, Susan A, Read, Kevin D, Yeates, Clive, Gilbert, Ian H
Publicado 2013

The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

por Patterson, Stephen, Wyllie, Susan, Stojanovski, Laste, Perry, Meghan R., Simeons, Frederick R. C., Norval, Suzanne, Osuna-Cabello, Maria, De Rycker, Manu, Read, Kevin D., Fairlamb, Alan H.
Publicado 2013

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

por Barini, Erica, Miccoli, Ageo, Tinarelli, Federico, Mulholland, Katie, Kadri, Hachemi, Khanim, Farhat, Stojanovski, Laste, Read, Kevin D., Burness, Kerry, Blow, Julian J., Mehellou, Youcef, Muqit, Miratul M. K.
Publicado 2018

Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform

por Gruber, Franz S, Johnston, Zoe C, Norcross, Neil R, Georgiou, Irene, Wilson, Caroline, Read, Kevin D, Gilbert, Ian H, Swedlow, Jason R, Martins da Silva, Sarah, Barratt, Christopher L R
Publicado 2022