Adapt or Die: Targeting Unique Transmission-Stage Biology for Malaria Elimination

por van der Watt, Mariëtte E., Reader, Janette, Birkholtz, Lyn-Marié
Publicado 2022

Streamlined and Robust Stage-Specific Profiling of Gametocytocidal Compounds Against Plasmodium falciparum

por Reader, Janette, van der Watt, Mariette E., Birkholtz, Lyn-Marié
Publicado 2022

Differential activity of novel gametocytocidal compounds: drug mode-of-action and ex vivo efficacy

por Birkholtz, Lyn-Marie, LeRoy, Didier, Reader, Janette, Botha, Mariette, Mancama, Dalu, Coetzer, Theresa L
Publicado 2014

H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum

por Connacher, Jessica, Josling, Gabrielle A., Orchard, Lindsey M., Reader, Janette, Llinás, Manuel, Birkholtz, Lyn-Marié
Publicado 2021

Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites

por Coetzee, Nanika, von Grüning, Hilde, Opperman, Daniel, van der Watt, Mariette, Reader, Janette, Birkholtz, Lyn-Marié
Publicado 2020

The ecdysone receptor regulates several key physiological factors in Anopheles funestus

por Maharaj, Surina, Ekoka, Elodie, Erlank, Erica, Nardini, Luisa, Reader, Janette, Birkholtz, Lyn-Marie, Koekemoer, Lizette L.
Publicado 2022

A Dynamic and Combinatorial Histone Code Drives Malaria Parasite Asexual and Sexual Development

por von Grüning, Hilde, Coradin, Mariel, Mendoza, Mariel R., Reader, Janette, Sidoli, Simone, Garcia, Benjamin A., Birkholtz, Lyn-Marié
Publicado 2022

Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation

por van Biljon, Riëtte, van Wyk, Roelof, Painter, Heather J., Orchard, Lindsey, Reader, Janette, Niemand, Jandeli, Llinás, Manuel, Birkholtz, Lyn-Marie
Publicado 2019

The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside

por Gibhard, Liezl, Coertzen, Dina, Reader, Janette, van der Watt, Mariëtte E., Birkholtz, Lyn-Marie, Wong, Ho Ning, Batty, Kevin T., Haynes, Richard K., Wiesner, Lubbe
Publicado 2021

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination

por Reader, Janette, Botha, Mariëtte, Theron, Anjo, Lauterbach, Sonja B, Rossouw, Claire, Engelbrecht, Dewaldt, Wepener, Melanie, Smit, Annél, Leroy, Didier, Mancama, Dalu, Coetzer, Theresa L, Birkholtz, Lyn-Marie
Publicado 2015

Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products

por Moyo, Phanankosi, Shamburger, William, van der Watt, Mariëtte E., Reader, Janette, de Sousa, Ana Carolina C., Egan, Timothy J., Maharaj, Vinesh J., Bringmann, Gerhard, Birkholtz, Lyn-Marie
Publicado 2020

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

por van Biljon, Riëtte, Niemand, Jandeli, van Wyk, Roelof, Clark, Katherine, Verlinden, Bianca, Abrie, Clarissa, von Grüning, Hilde, Smidt, Werner, Smit, Annél, Reader, Janette, Painter, Heather, Llinás, Manuel, Doerig, Christian, Birkholtz, Lyn-Marié
Publicado 2018

Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C...

por Wong, Ho Ning, Padín-Irizarry, Vivian, van der Watt, Mariëtte E., Reader, Janette, Liebenberg, Wilna, Wiesner, Lubbe, Smith, Peter, Eribez, Korina, Winzeler, Elizabeth A., Kyle, Dennis E., Birkholtz, Lyn-Marie, Coertzen, Dina, Haynes, Richard K.
Publicado 2020

Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer

por Abacha, Yabalu Z., Forkuo, Arnold Donkor, Gbedema, Stephen Y., Mittal, Nimisha, Ottilie, Sabine, Rocamora, Frances, Winzeler, Elizabeth A., van Schalkwyk, Donelly A., Kelly, John M., Taylor, Martin C., Reader, Janette, Birkholtz, Lyn-Marie, Lisgarten, David R., Cockcroft, Jeremy K., Lisgarten, John N., Palmer, Rex A., Talbert, Rosemary C., Shnyder, Steven D., Wright, Colin W.
Publicado 2022

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

por Reader, Janette, van der Watt, Mariëtte E., Taylor, Dale, Le Manach, Claire, Mittal, Nimisha, Ottilie, Sabine, Theron, Anjo, Moyo, Phanankosi, Erlank, Erica, Nardini, Luisa, Venter, Nelius, Lauterbach, Sonja, Bezuidenhout, Belinda, Horatscheck, Andre, van Heerden, Ashleigh, Spillman, Natalie J., Cowell, Anne N., Connacher, Jessica, Opperman, Daniel, Orchard, Lindsey M., Llinás, Manuel, Istvan, Eva S., Goldberg, Daniel E., Boyle, Grant A., Calvo, David, Mancama, Dalu, Coetzer, Theresa L., Winzeler, Elizabeth A., Duffy, James, Koekemoer, Lizette L., Basarab, Gregory, Chibale, Kelly, Birkholtz, Lyn-Marié
Publicado 2021