Mitigating RNA Toxicity in Myotonic Dystrophy using Small Molecules

por Reddy, Kaalak, Jenquin, Jana R., Cleary, John D., Berglund, J. Andrew
Publicado 2019

Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats

por Reddy, Kaalak, Tam, Mandy, Bowater, Richard P., Barber, Miriam, Tomlinson, Matthew, Nichol Edamura, Kerrie, Wang, Yuh-Hwa, Pearson, Christopher E.
Publicado 2011

Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability

por Reddy, Kaalak, Schmidt, Monika H.M., Geist, Jaimie M., Thakkar, Neha P., Panigrahi, Gagan B., Wang, Yuh-Hwa, Pearson, Christopher E.
Publicado 2014

Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy

por Mishra, Subodh K., Hicks, Sawyer M., Frias, Jesus A., Vangaveti, Sweta, Nakamori, Masayuki, Cleary, John D., Reddy, Kaalak, Berglund, J. Andrew
Publicado 2023

Interconverting Conformations of Slipped-DNA Junctions Formed by Trinucleotide Repeats Affect Repair Outcome

por Slean, Meghan M., Reddy, Kaalak, Wu, Bin, Nichol Edamura, Kerrie, Kekis, Mariana, Nelissen, Frank H. T., Aspers, Ruud L. E. G., Tessari, Marco, Schärer, Orlando D., Wijmenga, Sybren S., Pearson, Christopher E.
Publicado 2013

Disease-associated inosine misincorporation into RNA hinders translation

por Schroader, Jacob H, Jones, Lindsey A, Meng, Ryan, Shorrock, Hannah K, Richardson, Jared I, Shaughnessy, Sharon M, Lin, Qishan, Begley, Thomas J, Berglund, J Andrew, Fuchs, Gabriele, Handley, Mark T, Reddy, Kaalak
Publicado 2022

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model

por Moss, Chloe F., Dalla Rosa, Ilaria, Hunt, Lilian E., Yasukawa, Takehiro, Young, Robert, Jones, Aleck W. E., Reddy, Kaalak, Desai, Radha, Virtue, Sam, Elgar, Greg, Voshol, Peter, Taylor, Martin S., Holt, Ian J., Reijns, Martin A. M., Spinazzola, Antonella
Publicado 2017

Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response

por Mackenzie, Karen J, Carroll, Paula, Lettice, Laura, Tarnauskaitė, Žygimantė, Reddy, Kaalak, Dix, Flora, Revuelta, Ailsa, Abbondati, Erika, Rigby, Rachel E, Rabe, Björn, Kilanowski, Fiona, Grimes, Graeme, Fluteau, Adeline, Devenney, Paul S, Hill, Robert E, Reijns, Martin AM, Jackson, Andrew P
Publicado 2016

ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy

por Handley, Mark T., Reddy, Kaalak, Wills, Jimi, Rosser, Elisabeth, Kamath, Archith, Halachev, Mihail, Falkous, Gavin, Williams, Denise, Cox, Phillip, Meynert, Alison, Raymond, Eleanor S., Morrison, Harris, Brown, Stephen, Allan, Emma, Aligianis, Irene, Jackson, Andrew P., Ramsahoye, Bernard H., von Kriegsheim, Alex, Taylor, Robert W., Finch, Andrew J., FitzPatrick, David R.
Publicado 2019

CCG•CGG interruptions in high‐penetrance SCA8 families increase RAN translation and protein toxicity

por Perez, Barbara A, Shorrock, Hannah K, Banez‐Coronel, Monica, Zu, Tao, Romano, Lisa EL, Laboissonniere, Lauren A, Reid, Tammy, Ikeda, Yoshio, Reddy, Kaalak, Gomez, Christopher M, Bird, Thomas, Ashizawa, Tetsuo, Schut, Lawrence J, Brusco, Alfredo, Berglund, J Andrew, Hasholt, Lis F, Nielsen, Jorgen E, Subramony, SH, Ranum, Laura PW
Publicado 2021

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

por Harley, Margaret E., Murina, Olga, Leitch, Andrea, Higgs, Martin R., Bicknell, Louise S., Yigit, Gökhan, Blackford, Andrew N., Zlatanou, Anastasia, Mackenzie, Karen J., Reddy, Kaalak, Halachev, Mihail, McGlasson, Sarah, Reijns, Martin A. M., Fluteau, Adeline, Martin, Carol-Anne, Sabbioneda, Simone, Elcioglu, Nursel H., Altmüller, Janine, Thiele, Holger, Greenhalgh, Lynn, Chessa, Luciana, Maghnie, Mohamad, Salim, Mahmoud, Bober, Michael B., Nürnberg, Peter, Jackson, Stephen P., Hurles, Matthew E., Wollnik, Bernd, Stewart, Grant S., Jackson, Andrew P.
Publicado 2015