Localisation of AMPK γ subunits in cardiac and skeletal muscles

por Pinter, Katalin, Grignani, Robert T., Watkins, Hugh, Redwood, Charles
Publicado 2013

Fluorescent PSC-Derived Cardiomyocyte Reporter Lines: Generation Approaches and Their Applications in Cardiovascular Medicine

por Sontayananon, Naeramit, Redwood, Charles, Davies, Benjamin, Gehmlich, Katja
Publicado 2020

Determination of AMP-activated protein kinase phosphorylation sites in recombinant protein expressed using the pET28a vector: A cautionary tale

por Renz, Bernhard, Davies, Joanna K., Carling, David, Watkins, Hugh, Redwood, Charles
Publicado 2009

Embryonic expression of AMPK γ subunits and the identification of a novel γ2 transcript variant in adult heart

por Pinter, Katalin, Grignani, Robert T., Czibik, Gabor, Farza, Hend, Watkins, Hugh, Redwood, Charles
Publicado 2012

Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca(2+) flux caused by thin filament hypertrophic cardiomyopathy mutations

por Sparrow, Alexander J., Watkins, Hugh, Daniels, Matthew J., Redwood, Charles, Robinson, Paul
Publicado 2020

Looking for Targets to Restore the Contractile Function in Congenital Myopathy Caused by Gln(147)Pro Tropomyosin

por Karpicheva, Olga E., Simonyan, Armen O., Rysev, Nikita A., Redwood, Charles S., Borovikov, Yurii S.
Publicado 2020

Molecular Mechanisms of Deregulation of Muscle Contractility Caused by the R168H Mutation in TPM3 and Its Attenuation by Therapeutic Agents

por Karpicheva, Olga E., Avrova, Stanislava V., Bogdanov, Andrey L., Sirenko, Vladimir V., Redwood, Charles S., Borovikov, Yurii S.
Publicado 2023

Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca(2+) Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation

por Borovikov, Yurii S., Simonyan, Armen O., Avrova, Stanislava V., Sirenko, Vladimir V., Redwood, Charles S., Karpicheva, Olga E.
Publicado 2020

Genetics Matters: Voyaging from the Past into the Future of Humanity and Sustainability

por Cheng, Acga, Harikrishna, Jennifer Ann, Redwood, Charles S., Lit, Lei Cheng, Nath, Swapan K., Chua, Kek Heng
Publicado 2022

Hypertrophic cardiomyopathy mutations increase myofilament Ca(2+) buffering, alter intracellular Ca(2+) handling, and stimulate Ca(2+)-dependent signaling

por Robinson, Paul, Liu, Xing, Sparrow, Alexander, Patel, Suketu, Zhang, Yin-Hua, Casadei, Barbara, Watkins, Hugh, Redwood, Charles
Publicado 2018

Molecular mechanisms of dysfunction of muscle fibres associated with Glu139 deletion in TPM2 gene

por Borovikov, Yurii S., Rysev, Nikita A., Karpicheva, Olga E., Sirenko, Vladimir V., Avrova, Stanislava V., Piers, Adam, Redwood, Charles S.
Publicado 2017

The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies

por Borovikov, Yurii S., Karpicheva, Olga E., Simonyan, Armen O., Avrova, Stanislava V., Rogozovets, Elena A., Sirenko, Vladimir V., Redwood, Charles S.
Publicado 2018

Molecular Mechanisms of the Deregulation of Muscle Contraction Induced by the R90P Mutation in Tpm3.12 and the Weakening of This Effect by BDM and W7

por Borovikov, Yurii S., Andreeva, Daria D., Avrova, Stanislava V., Sirenko, Vladimir V., Simonyan, Armen O., Redwood, Charles S., Karpicheva, Olga E.
Publicado 2021

Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue

por Kresin, Nico, Stücker, Sabrina, Krämer, Elisabeth, Flenner, Frederik, Mearini, Giulia, Münch, Julia, Patten, Monica, Redwood, Charles, Carrier, Lucie, Friedrich, Felix W.
Publicado 2019

Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca(2+), and activate NFAT and Akt signaling

por Robinson, Paul, Sparrow, Alexander J., Patel, Suketu, Malinowska, Marta, Reilly, Svetlana N., Zhang, Yin-Hua, Casadei, Barbara, Watkins, Hugh, Redwood, Charles
Publicado 2020

Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy

por Sequeira, Vasco, Wang, Lili, Wijnker, Paul J.M., Kim, Kyungsoo, Pinto, Jose R., dos Remedios, Cris, Redwood, Charles, Knollmann, Bjorn C., van der Velden, Jolanda
Publicado 2022

Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation()

por Messer, Andrew E., Bayliss, Christopher R., El-Mezgueldi, Mohammed, Redwood, Charles S., Ward, Douglas G., Leung, Man-Ching, Papadaki, Maria, dos Remedios, Cristobal, Marston, Steven B.
Publicado 2016

Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations

por Sparrow, Alexander J., Sievert, Kolja, Patel, Suketu, Chang, Yu-Fen, Broyles, Connor N., Brook, Frances A., Watkins, Hugh, Geeves, Michael A., Redwood, Charles S., Robinson, Paul, Daniels, Matthew J.
Publicado 2019

Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes

por Prondzynski, Maksymilian, Krämer, Elisabeth, Laufer, Sandra D., Shibamiya, Aya, Pless, Ole, Flenner, Frederik, Müller, Oliver J., Münch, Julia, Redwood, Charles, Hansen, Arne, Patten, Monica, Eschenhagen, Thomas, Mearini, Giulia, Carrier, Lucie
Publicado 2017

Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice

por Smart, Nicola, Riegler, Johannes, Turtle, Cameron W., Lygate, Craig A., McAndrew, Debra J., Gehmlich, Katja, Dubé, Karina N., Price, Anthony N., Muthurangu, Vivek, Taylor, Andrew M., Lythgoe, Mark F., Redwood, Charles, Riley, Paul R.
Publicado 2017