Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies

por Vogan, Jacob M, Zhang, Xiaozhu, Youmans, Daniel T, Regalado, Samuel G, Johnson, Joshua Z, Hockemeyer, Dirk, Collins, Kathleen
Publicado 2016

Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1

por Boyle, John M., Hennick, Kelsey M., Regalado, Samuel G., Vogan, Jacob M., Zhang, Xiaozhu, Collins, Kathleen, Hockemeyer, Dirk
Publicado 2020

Editing TINF2 as a potential therapeutic approach to restore telomere length in dyskeratosis congenita

por Choo, Seunga, Lorbeer, Franziska K., Regalado, Samuel G., Short, Sarah B., Wu, Shannon, Rieser, Gabrielle, Bertuch, Alison A., Hockemeyer, Dirk
Publicado 2022

A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cells

por Turkalo, Timothy K., Maffia, Antonio, Schabort, Johannes J., Regalado, Samuel G., Bhakta, Mital, Blanchette, Marco, Spierings, Diana C. J., Lansdorp, Peter M., Hockemeyer, Dirk
Publicado 2023

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

por Sexton, Alec N., Regalado, Samuel G., Lai, Christine S., Cost, Gregory J., O’Neil, Colleen M., Urnov, Fyodor D., Gregory, Philip D., Jaenisch, Rudolf, Collins, Kathleen, Hockemeyer, Dirk
Publicado 2014

A time-resolved, multi-symbol molecular recorder via sequential genome editing

por Choi, Junhong, Chen, Wei, Minkina, Anna, Chardon, Florence M., Suiter, Chase C., Regalado, Samuel G., Domcke, Silvia, Hamazaki, Nobuhiko, Lee, Choli, Martin, Beth, Daza, Riza M., Shendure, Jay
Publicado 2022

Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy

por McFaline-Figueroa, José L., Srivatsan, Sanjay, Hill, Andrew J., Gasperini, Molly, Jackson, Dana L., Saunders, Lauren, Domcke, Silvia, Regalado, Samuel G., Lazarchuck, Paul, Alvarez, Sarai, Monnat, Raymond J., Shendure, Jay, Trapnell, Cole
Publicado 2023

Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells

por Forster, Ryan, Chiba, Kunitoshi, Schaeffer, Lorian, Regalado, Samuel G., Lai, Christine S., Gao, Qing, Kiani, Samira, Farin, Henner F., Clevers, Hans, Cost, Gregory J., Chan, Andy, Rebar, Edward J., Urnov, Fyodor D., Gregory, Philip D., Pachter, Lior, Jaenisch, Rudolf, Hockemeyer, Dirk
Publicado 2014

Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells

por Forster, Ryan, Chiba, Kunitoshi, Schaeffer, Lorian, Regalado, Samuel G., Lai, Christine S., Gao, Qing, Kiani, Samira, Farin, Henner F., Clevers, Hans, Cost, Gregory J., Chan, Andy, Rebar, Edward J., Urnov, Fyodor D., Gregory, Philip D., Pachter, Lior, Jaenisch, Rudolf, Hockemeyer, Dirk
Publicado 2014