Gene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate Leishmania major

por Balaña-Fouce, Rafael, García-Estrada, Carlos, Pérez-Pertejo, Yolanda, Reguera, Rosa M
Publicado 2008

Target-based vs. phenotypic screenings in Leishmania drug discovery: A marriage of convenience or a dialogue of the deaf?

por Reguera, Rosa M., Calvo-Álvarez, Estefanía, Álvarez-Velilla, Raquel, Balaña-Fouce, Rafael
Publicado 2014

Deletion Study of DNA Topoisomerase IB from Leishmania donovani: Searching for a Minimal Functional Heterodimer

por Díaz González, Rosario, Pérez Pertejo, Yolanda, Ordóñez, David, Balaña-Fouce, Rafael, Reguera, Rosa M.
Publicado 2007

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery

por Balaña-Fouce, Rafael, Álvarez-Velilla, Raquel, Fernández-Prada, Christopher, García-Estrada, Carlos, Reguera, Rosa M.
Publicado 2014

The transcriptome of Leishmania major in the axenic promastigote stage: transcript annotation and relative expression levels by RNA-seq

por Rastrojo, Alberto, Carrasco-Ramiro, Fernando, Martín, Diana, Crespillo, Antonio, Reguera, Rosa M, Aguado, Begoña, Requena, Jose M
Publicado 2013

Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin

por Carballeira, Néstor M., Montano, Nashbly, Alvarez-Velilla, Raquel, Prada, Christopher F., Reguera, Rosa M., Balaña-Fouce, Rafael
Publicado 2013

Miltefosine and Nifuratel Combination: A Promising Therapy for the Treatment of Leishmania donovani Visceral Leishmaniasis

por Melcon-Fernandez, Estela, Galli, Giulio, García-Estrada, Carlos, Balaña-Fouce, Rafael, Reguera, Rosa M., Pérez-Pertejo, Yolanda
Publicado 2023

Identification and Characterization of the Regions Involved in the Nuclear Translocation of the Heterodimeric Leishmanial DNA Topoisomerase IB

por Prada, Christopher F., Álvarez-Velilla, Raquel, Díaz-Gozález, Rosario, Pérez-Pertejo, Yolanda, Balaña-Fouce, Rafael, Reguera, Rosa M.
Publicado 2013

First Evidence of Intraclonal Genetic Exchange in Trypanosomatids Using Two Leishmania infantum Fluorescent Transgenic Clones

por Calvo-Álvarez, Estefanía, Álvarez-Velilla, Raquel, Jiménez, Maribel, Molina, Ricardo, Pérez-Pertejo, Yolanda, Balaña-Fouce, Rafael, Reguera, Rosa M.
Publicado 2014

Correction: First Evidence of Intraclonal Genetic Exchange in Trypanosomatids Using Two Leishmania infantum Fluorescent Transgenic Clones

por Calvo-Álvarez, Estefanía, Álvarez-Velilla, Raquel, Jiménez, Maribel, Molina, Ricardo, Pérez-Pertejo, Yolanda, Balaña-Fouce, Rafael, Reguera, Rosa M.
Publicado 2016

Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum

por Gutiérrez-Corbo, Camino, Álvarez-Velilla, Raquel, Reguera, Rosa M., García-Estrada, Carlos, Cushman, Mark, Balaña-Fouce, Rafael, Pérez-Pertejo, Yolanda
Publicado 2019

Antiparasitic effect of synthetic aromathecins on Leishmania infantum

por Reguera, Rosa M., Álvarez-Velilla, Raquel, Domínguez-Asenjo, Bárbara, Gutiérrez-Corbo, Camino, Balaña-Fouce, Rafael, Cushman, Mark, Pérez-Pertejo, Yolanda
Publicado 2019

Mannose-Decorated Dendritic Polyglycerol Nanocarriers Drive Antiparasitic Drugs To Leishmania infantum-Infected Macrophages

por Vossen, Laura I., Domínguez-Asenjo, Bárbara, Gutiérrez-Corbo, Camino, Pérez-Pertejo, M. Yolanda, Balaña-Fouce, Rafael, Reguera, Rosa María, Calderón, Marcelo
Publicado 2020

Reproduction in Trypanosomatids: Past and Present

por Gutiérrez-Corbo, Camino, Domínguez-Asenjo, Bárbara, Martínez-Valladares, María, Pérez-Pertejo, Yolanda, García-Estrada, Carlos, Balaña-Fouce, Rafael, Reguera, Rosa M.
Publicado 2021

Axenic interspecies and intraclonal hybrid formation in Leishmania: Successful crossings between visceral and cutaneous strains

por Gutiérrez-Corbo, Camino, Domínguez-Asenjo, Bárbara, Pérez-Pertejo, Yolanda, García-Estrada, Carlos, Bello, Felio J, Balaña-Fouce, Rafael, Reguera, Rosa M.
Publicado 2022

A chronic bioluminescent model of experimental visceral leishmaniasis for accelerating drug discovery

por Álvarez-Velilla, Raquel, Gutiérrez-Corbo, Maria del Camino, Punzón, Carmen, Pérez-Pertejo, Maria Yolanda, Balaña-Fouce, Rafael, Fresno, Manuel, Reguera, Rosa María
Publicado 2019

Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates

por García-Estrada, Carlos, Pérez-Pertejo, Yolanda, Domínguez-Asenjo, Bárbara, Holanda, Vanderlan Nogueira, Murugesan, Sankaranarayanan, Martínez-Valladares, María, Balaña-Fouce, Rafael, Reguera, Rosa M.
Publicado 2023

Hybrid Quinolinyl Phosphonates as Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation against Topoisomerase 1B (TOP1B)

por Selas, Asier, Fuertes, María, Melcón-Fernández, Estela, Pérez-Pertejo, Yolanda, Reguera, Rosa M., Balaña-Fouce, Rafael, Knudsen, Birgitta R., Palacios, Francisco, Alonso, Concepcion
Publicado 2021

Characterization of the Gene Encoding S-adenosyl-L-methionine (AdoMet) Synthetase in Penicillium chrysogenum; Role in Secondary Metabolism and Penicillin Production

por Domínguez-Santos, Rebeca, Kosalková, Katarina, Sánchez-Orejas, Isabel-Clara, Barreiro, Carlos, Pérez-Pertejo, Yolanda, Reguera, Rosa M., Balaña-Fouce, Rafael, García-Estrada, Carlos
Publicado 2021

Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB

por Pérez-Pertejo, Yolanda, Escudero-Martínez, José M., Reguera, Rosa M., Balaña-Fouce, Rafael, García, Pablo A., Jambrina, Pablo G., San Feliciano, Arturo, Castro, María-Ángeles
Publicado 2019