STING is redundant for host defense and pathology of COVID-19-like disease in mice

por Marino, Giorgia, Zhang, Baocun, Schmitz, Alexander, Schwensen, Hanna VF, Reinert, Line S, Paludan, Søren R
Publicado 2023

TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain

por Fruhwürth, Stefanie, Reinert, Line S., Öberg, Carl, Sakr, Marcelina, Henricsson, Marcus, Zetterberg, Henrik, Paludan, Søren R.
Publicado 2023

STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice

por Skouboe, Morten K., Knudsen, Alice, Reinert, Line S., Boularan, Cedric, Lioux, Thierry, Perouzel, Eric, Thomsen, Martin K., Paludan, Søren R.
Publicado 2018

ER stress induces caspase‐2‐tBID‐GSDME‐dependent cell death in neurons lytically infected with herpes simplex virus type 2

por Ren, Fanghui, Narita, Ryo, Rashidi, Ahmad S, Fruhwürth, Stefanie, Gao, Zongliang, Bak, Rasmus O, Thomsen, Martin K, Verjans, Georges MGM, Reinert, Line S, Paludan, Søren R
Publicado 2023

Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer

por Thomsen, Mathilde Borg Houlberg, Nordentoft, Iver, Lamy, Philippe, Vang, Søren, Reinert, Line, Mapendano, Christophe Kamungu, Høyer, Søren, Ørntoft, Torben F., Jensen, Jørgen Bjerggaard, Dyrskjøt, Lars
Publicado 2017

B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation

por Green, Kenneth, Wittenborn, Thomas R., Fahlquist-Hagert, Cecilia, Terczynska-Dyla, Ewa, van Campen, Nina, Jensen, Lisbeth, Reinert, Line, Hartmann, Rune, Paludan, Søren R., Degn, Søren E.
Publicado 2021

Interleukin-21 Receptor Signalling Is Important for Innate Immune Protection against HSV-2 Infections

por Kratholm, Sine K., Iversen, Marie B., Reinert, Line, Jensen, Simon K., Hokland, Marianne, Andersen, Thomas, Rankin, Andrew, Young, Deborah, Frische, Sebastian, Paludan, Søren R., Holm, Christian K.
Publicado 2013

The alternative cap-binding complex is required for antiviral defense in vivo

por Gebhardt, Anna, Bergant, Valter, Schnepf, Daniel, Moser, Markus, Meiler, Arno, Togbe, Dieudonnée, Mackowiak, Claire, Reinert, Line S., Paludan, Søren R., Ryffel, Bernhard, Stukalov, Alexey, Staeheli, Peter, Pichlmair, Andreas
Publicado 2019

Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS

por Reinert, Line S., Lopušná, Katarína, Winther, Henriette, Sun, Chenglong, Thomsen, Martin K., Nandakumar, Ramya, Mogensen, Trine H., Meyer, Morten, Vægter, Christian, Nyengaard, Jens R., Fitzgerald, Katherine A., Paludan, Søren R.
Publicado 2016

SARS‐CoV‐2 evades immune detection in alveolar macrophages

por Dalskov, Louise, Møhlenberg, Michelle, Thyrsted, Jacob, Blay‐Cadanet, Julia, Poulsen, Ebbe Toftgaard, Folkersen, Birgitte Holst, Skaarup, Søren Helbo, Olagnier, David, Reinert, Line, Enghild, Jan Johannes, Hoffmann, Hans Jürgen, Holm, Christian Kanstrup, Hartmann, Rune
Publicado 2020

The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice

por Bayarri-Olmos, Rafael, Johnsen, Laust Bruun, Idorn, Manja, Reinert, Line S, Rosbjerg, Anne, Vang, Søren, Hansen, Cecilie Bo, Helgstrand, Charlotte, Bjelke, Jais Rose, Bak-Thomsen, Theresa, Paludan, Søren R, Garred, Peter, Skjoedt, Mikkel-Ole
Publicado 2021

A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry

por Valero, Julián, Civit, Laia, Dupont, Daniel M., Selnihhin, Denis, Reinert, Line S., Idorn, Manja, Israels, Brett A., Bednarz, Aleksandra M., Bus, Claus, Asbach, Benedikt, Peterhoff, David, Pedersen, Finn S., Birkedal, Victoria, Wagner, Ralf, Paludan, Søren R., Kjems, Jørgen
Publicado 2021

HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

por Bodda, Chiranjeevi, Reinert, Line S., Fruhwürth, Stefanie, Richardo, Timmy, Sun, Chenglong, Zhang, Bao-cun, Kalamvoki, Maria, Pohlmann, Anja, Mogensen, Trine H., Bergström, Petra, Agholme, Lotta, O’Hare, Peter, Sodeik, Beate, Gyrd-Hansen, Mads, Zetterberg, Henrik, Paludan, Søren R.
Publicado 2020

STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

por Vila, Isabelle K., Chamma, Hanane, Steer, Alizée, Saccas, Mathilde, Taffoni, Clara, Turtoi, Evgenia, Reinert, Line S., Hussain, Saqib, Marines, Johanna, Jin, Lei, Bonnefont, Xavier, Hubert, Mathieu, Schwartz, Olivier, Paludan, Soren R., Van Simaeys, Gaetan, Doumont, Gilles, Sobhian, Bijan, Vlachakis, Dimitrios, Turtoi, Andrei, Laguette, Nadine
Publicado 2022

Functional IRF3 deficiency in a patient with herpes simplex encephalitis

por Andersen, Line Lykke, Mørk, Nanna, Reinert, Line S., Kofod-Olsen, Emil, Narita, Ryo, Jørgensen, Sofie E., Skipper, Kristian A., Höning, Klara, Gad, Hans Henrik, Østergaard, Lars, Ørntoft, Torben F., Hornung, Veit, Paludan, Søren R., Mikkelsen, Jacob Giehm, Fujita, Takashi, Christiansen, Mette, Hartmann, Rune, Mogensen, Trine H.
Publicado 2015

TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection

por van der Sluis, Renée M, Cham, Lamin B, Gris‐Oliver, Albert, Gammelgaard, Kristine R, Pedersen, Jesper G, Idorn, Manja, Ahmadov, Ulvi, Hernandez, Sabina Sanches, Cémalovic, Ena, Godsk, Stine H, Thyrsted, Jacob, Gunst, Jesper D, Nielsen, Silke D, Jørgensen, Janni J, Bjerg, Tobias Wang, Laustsen, Anders, Reinert, Line S, Olagnier, David, Bak, Rasmus O, Kjolby, Mads, Holm, Christian K, Tolstrup, Martin, Paludan, Søren R, Kristensen, Lasse S, Søgaard, Ole S, Jakobsen, Martin R
Publicado 2022

STEEP mediates STING ER exit and activation of signaling

por Zhang, Bao-cun, Nandakumar, Ramya, Reinert, Line S, Huang, Jinrong, Laustsen, Anders, Gao, Zong-liang, Sun, Cheng-long, Jensen, Søren Beck, Troldborg, Anne, Assil, Sonia, Berthelsen, Martin F., Scavenius, Carsten, Zhang, Yan, Windross, Samuel J, Olagnier, David, Prabakaran, Thaneas, Bodda, Chiranjeevi, Narita, Ryo, Cai, Yujia, Zhang, Cong-gang, Stenmark, Harald, Doucet, Christine M, Noda, Takeshi, Guo, Zheng, Goldbach-Mansky, Raphaela, Hartmann, Rune, Chen, Zhijian J, Enghild, Jan J, Bak, Rasmus O, Thomsen, Martin K., Paludan, Søren R
Publicado 2020

Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen

por Taha, Zaid, Arulanandam, Rozanne, Maznyi, Glib, Godbout, Elena, Carter-Timofte, Madalina E., Kurmasheva, Naziia, Reinert, Line S., Chen, Andrew, Crupi, Mathieu J.F., Boulton, Stephen, Laroche, Geneviève, Phan, Alexandra, Rezaei, Reza, Alluqmani, Nouf, Jirovec, Anna, Acal, Alexandra, Brown, Emily E.F., Singaravelu, Ragunath, Petryk, Julia, Idorn, Manja, Potts, Kyle G., Todesco, Hayley, John, Cini, Mahoney, Douglas J., Ilkow, Carolina S., Giguère, Patrick, Alain, Tommy, Côté, Marceline, Paludan, Søren R., Olagnier, David, Bell, John C., Azad, Taha, Diallo, Jean-Simon
Publicado 2022

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

por Olagnier, David, Farahani, Ensieh, Thyrsted, Jacob, Blay-Cadanet, Julia, Herengt, Angela, Idorn, Manja, Hait, Alon, Hernaez, Bruno, Knudsen, Alice, Iversen, Marie Beck, Schilling, Mirjam, Jørgensen, Sofie E., Thomsen, Michelle, Reinert, Line S., Lappe, Michael, Hoang, Huy-Dung, Gilchrist, Victoria H., Hansen, Anne Louise, Ottosen, Rasmus, Nielsen, Camilla G., Møller, Charlotte, van der Horst, Demi, Peri, Suraj, Balachandran, Siddharth, Huang, Jinrong, Jakobsen, Martin, Svenningsen, Esben B., Poulsen, Thomas B., Bartsch, Lydia, Thielke, Anne L., Luo, Yonglun, Alain, Tommy, Rehwinkel, Jan, Alcamí, Antonio, Hiscott, John, Mogensen, Trine, Paludan, Søren R., Holm, Christian K.
Publicado 2020

Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

por Olagnier, David, Farahani, Ensieh, Thyrsted, Jacob, Blay-Cadanet, Julia, Herengt, Angela, Idorn, Manja, Hait, Alon, Hernaez, Bruno, Knudsen, Alice, Iversen, Marie Beck, Schilling, Mirjam, Jørgensen, Sofie E., Thomsen, Michelle, Reinert, Line S., Lappe, Michael, Hoang, Huy-Dung, Gilchrist, Victoria H., Hansen, Anne Louise, Ottosen, Rasmus, Nielsen, Camilla G., Møller, Charlotte, van der Horst, Demi, Peri, Suraj, Balachandran, Siddharth, Huang, Jinrong, Jakobsen, Martin, Svenningsen, Esben B., Poulsen, Thomas B., Bartsch, Lydia, Thielke, Anne L., Luo, Yonglun, Alain, Tommy, Rehwinkel, Jan, Alcamí, Antonio, Hiscott, John, Mogensen, Trine H., Paludan, Søren R., Holm, Christian K.
Publicado 2020