On the road to inflammation: Linking lysosome disruption, lysosomal protease release and necrotic death of immune cells

por Reinheckel, Thomas
Publicado 2013

New Kid on the Block

por Reinheckel, Thomas
Publicado 2017

Low‐level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus

por Reinheckel, Thomas, Tholen, Martina
Publicado 2022

Cathepsin B & L Are Not Required for Ebola Virus Replication

por Marzi, Andrea, Reinheckel, Thomas, Feldmann, Heinz
Publicado 2012

Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS

por Ziltener, Pascal, Reinheckel, Thomas, Oxenius, Annette
Publicado 2016

Specific functions of lysosomal proteases in endocytic and autophagic pathways()

por Müller, Sabrina, Dennemärker, Julia, Reinheckel, Thomas
Publicado 2012

Dipeptidyl-Aminopeptidases 8 and 9 Regulate Autophagy and Tamoxifen Response in Breast Cancer Cells

por Bettecken, Aaron, Heß, Lisa, Hölzen, Lena, Reinheckel, Thomas
Publicado 2023

Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target

por Reinheckel, Thomas, Peters, Christoph, Krüger, Achim, Turk, Boris, Vasiljeva, Olga
Publicado 2012

Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells

por Kern, Ursula, Wischnewski, Vladimir, Biniossek, Martin L, Schilling, Oliver, Reinheckel, Thomas
Publicado 2015

BRAF(V600E) drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation

por Reischmann, Nadine, Andrieux, Geoffroy, Griffin, Ricarda, Reinheckel, Thomas, Boerries, Melanie, Brummer, Tilman
Publicado 2020

Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-β signaling

por Ni, Junjun, Zhao, Juan, Zhang, Xinwen, Reinheckel, Thomas, Turk, Vito, Nakanishi, Hiroshi
Publicado 2021

Degradome-focused RNA interference screens to identify proteases important for breast cancer cell growth

por Hölzen, Lena, Syré, Kerstin, Mitschke, Jan, Brummer, Tilman, Miething, Cornelius, Reinheckel, Thomas
Publicado 2022

Lysosomal processing of progranulin

por Zhou, Xiaolai, Paushter, Daniel H., Feng, Tuancheng, Sun, Lirong, Reinheckel, Thomas, Hu, Fenghua
Publicado 2017

Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

por Conus, Sébastien, Perozzo, Remo, Reinheckel, Thomas, Peters, Christoph, Scapozza, Leonardo, Yousefi, Shida, Simon, Hans-Uwe
Publicado 2008

Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression

por Sigloch, Florian Christoph, Tholen, Martina, Gomez-Auli, Alejandro, Biniossek, Martin Lothar, Reinheckel, Thomas, Schilling, Oliver
Publicado 2017

Cathepsin B in Antigen-Presenting Cells Controls Mediators of the Th1 Immune Response during Leishmania major Infection

por Gonzalez-Leal, Iris J., Röger, Bianca, Schwarz, Angela, Schirmeister, Tanja, Reinheckel, Thomas, Lutz, Manfred B., Moll, Heidrun
Publicado 2014

Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis

por Kasabova, Mariana, Villeret, Bérengère, Gombault, Aurélie, Lecaille, Fabien, Reinheckel, Thomas, Marchand-Adam, Sylvain, Couillin, Isabelle, Lalmanach, Gilles
Publicado 2016

Proteolysis-a characteristic of tumor-initiating cells in murine metastatic breast cancer

por Hillebrand, Larissa E., Bengsch, Fee, Hochrein, Jochen, Hülsdünker, Jan, Bender, Julia, Follo, Marie, Busch, Hauke, Boerries, Melanie, Reinheckel, Thomas
Publicado 2016

Asparaginyl Endopeptidase (Legumain) Supports Human Th1 Induction via Cathepsin L-Mediated Intracellular C3 Activation

por Freeley, Simon, Cardone, John, Günther, Sira C., West, Erin E., Reinheckel, Thomas, Watts, Colin, Kemper, Claudia, Kolev, Martin V.
Publicado 2018

Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression

por Parigiani, María Alejandra, Ketscher, Anett, Timme, Sylvia, Bronsert, Peter, Schlimpert, Manuel, Kammerer, Bernd, Jacquel, Arnaud, Chaintreuil, Paul, Reinheckel, Thomas
Publicado 2020