Coming to Terms with Complexity: Limits to a Reductionist View of Aging

por Shmookler Reis, Robert J.
Publicado 2012

Computational target-based drug repurposing of elbasvir, an antiviral drug predicted to bind multiple SARS-CoV-2 proteins

por Balasubramaniam, Meenakshisundaram, Reis, Robert J. Shmookler
Publicado 2020

Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2

por Balasubramaniam, Meenakshisundaram, Ayyadevara, Srinivas, Shmookler Reis, Robert J.
Publicado 2018

An iterative block-shifting approach to retention time alignment that preserves the shape and area of gas chromatography-mass spectrometry peaks

por Chae, Minho, Reis, Robert J Shmookler, Thaden, John J
Publicado 2008

A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin

por Alagpulinsa, David A., Ayyadevara, Srinivas, Shmookler Reis, Robert Joseph
Publicado 2014

Positive Feedback between Transcriptional and Kinase Suppression in Nematodes with Extraordinary Longevity and Stress Resistance

por Tazearslan, Çagdaþ, Ayyadevara, Srinivas, Bharill, Puneet, Shmookler Reis, Robert J.
Publicado 2009

Extreme Depletion of PIP(3) Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants

por Bharill, Puneet, Ayyadevara, Srinivas, Alla, Ramani, Shmookler Reis, Robert J.
Publicado 2013

Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration

por Ayyadevara, Srinivas, Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Shmookler Reis, Robert J.
Publicado 2021

Machine-learning analysis of intrinsically disordered proteins identifies key factors that contribute to neurodegeneration-related aggregation

por Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Ayyadevara, Srinivas, Shmookler Reis, Robert J.
Publicado 2022

A Narrow Quantitative Trait Locus in C. elegans Coordinately Affects Longevity, Thermotolerance, and Resistance to Paraquat

por Vertino, Anthony, Ayyadevara, Srinivas, Thaden, John J., Reis, Robert J. Shmookler
Publicado 2011

Protein homeostasis in the aged and diseased heart

por Mainali, Nirjal, Ayyadevara, Srinivas, Ganne, Akshatha, Shmookler Reis, Robert J., Mehta, Jawahar L.
Publicado 2023

Testing for treatment effects on gene ontology

por Lee, Taewon, Desai, Varsha G, Velasco, Cruz, Reis, Robert JS, Delongchamp, Robert R
Publicado 2008

Stability analysis of a model gene network links aging, stress resistance, and negligible senescence

por Kogan, Valeria, Molodtsov, Ivan, Menshikov, Leonid I., Reis, Robert J. Shmookler, Fedichev, Peter
Publicado 2015

Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease

por Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Griffin, W. Sue T., Shmookler Reis, Robert J., Ayyadevara, Srinivas
Publicado 2022

Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes

por Ayyadevara, Srinivas, Balasubramaniam, Meenakshisundaram, Gao, Yuan, Yu, Li-Rong, Alla, Ramani, Shmookler Reis, Robert
Publicado 2015

“Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation

por Shmookler Reis, Robert J., Atluri, Ramani, Balasubramaniam, Meenakshisundaram, Johnson, Jay, Ganne, Akshatha, Ayyadevara, Srinivas
Publicado 2021

Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases

por Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Mainali, Nirjal, Atluri, Paavan, Shmookler Reis, Robert J., Ayyadevara, Srinivas
Publicado 2022

Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae

por Ayyadevara, Srinivas, Tazearslan, Çagdas, Alla, Ramani, Jiang, James C., Jazwinski, S. Michal, Shmookler Reis, Robert J.
Publicado 2014

PIP(3)-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans

por Ayyadevara, Srinivas, Balasubramaniam, Meenakshisundaram, Johnson, Jay, Alla, Ramani, Mackintosh, Samuel G., Shmookler Reis, Robert J.
Publicado 2016

Label-free photothermal disruption of cytotoxic aggregates rescues pathology in a C. elegans model of Huntington’s disease

por Nedosekin, Dmitry A., Chen, TsungYen, Ayyadevara, Srinivas, Zharov, Vladimir P., Shmookler Reis, Robert J.
Publicado 2021