Omaveloxolone and TX63682 are hepatoprotective in the STAM mouse model of nonalcoholic steatohepatitis

por Reisman, Scott A., Ferguson, Deborah A., Lee, Chun‐Yue I., Proksch, Joel W.
Publicado 2020

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

por Aminzadeh, Mohammad A., Reisman, Scott A., Vaziri, Nosratola D., Khazaeli, Mahyar, Yuan, Jun, Meyer, Colin J.
Publicado 2014

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

por Reisman, Scott A, Gahir, Sarabjit S, Lee, Chun-Yue I, Proksch, Joel W, Sakamoto, Mitsumasa, Ward, Keith W
Publicado 2019

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease()

por Aminzadeh, Mohammad A., Reisman, Scott A., Vaziri, Nosratola D., Shelkovnikov, Stan, Farzaneh, Seyed H., Khazaeli, Mahyar, Meyer, Colin J.
Publicado 2013

Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers

por Reisman, Scott A., Goldsberry, Angela R., Lee, Chun-Yue I., O’Grady, Megan L., Proksch, Joel W., Ward, Keith W., Meyer, Colin J.
Publicado 2015

Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD

por Lewis, James H., Jadoul, Michel, Block, Geoffrey A., Chin, Melanie P., Ferguson, Deborah A., Goldsberry, Angie, Meyer, Colin J., O’Grady, Megan, Pergola, Pablo E., Reisman, Scott A., Wigley, W. Christian, Chertow, Glenn M.
Publicado 2020

Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

por Creelan, Ben C, Gabrilovich, Dmitry I, Gray, Jhanelle E, Williams, Charles C, Tanvetyanon, Tawee, Haura, Eric B, Weber, Jeffrey S, Gibney, Geoffrey T, Markowitz, Joseph, Proksch, Joel W, Reisman, Scott A, McKee, Mark D, Chin, Melanie P, Meyer, Colin J, Antonia, Scott J
Publicado 2017