Impact of Type II LRRK2 inhibitors on signaling and mitophagy

por Tasegian, Anna, Singh, Francois, Ganley, Ian G., Reith, Alastair D., Alessi, Dario R.
Publicado 2021

Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice

por Singh, Francois, Prescott, Alan R, Rosewell, Philippa, Ball, Graeme, Reith, Alastair D, Ganley, Ian G
Publicado 2021

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

por Dzamko, Nicolas, Deak, Maria, Hentati, Faycal, Reith, Alastair D., Prescott, Alan R., Alessi, Dario R., Nichols, R. Jeremy
Publicado 2010

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

por Ito, Genta, Katsemonova, Kristina, Tonelli, Francesca, Lis, Pawel, Baptista, Marco A.S., Shpiro, Natalia, Duddy, Graham, Wilson, Steve, Ho, Philip Wing-Lok, Ho, Shu-Leong, Reith, Alastair D., Alessi, Dario R.
Publicado 2016

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

por Steger, Martin, Tonelli, Francesca, Ito, Genta, Davies, Paul, Trost, Matthias, Vetter, Melanie, Wachter, Stefanie, Lorentzen, Esben, Duddy, Graham, Wilson, Stephen, Baptista, Marco AS, Fiske, Brian K, Fell, Matthew J, Morrow, John A, Reith, Alastair D, Alessi, Dario R, Mann, Matthias
Publicado 2016

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

por Härtlova, Anetta, Herbst, Susanne, Peltier, Julien, Rodgers, Angela, Bilkei‐Gorzo, Orsolya, Fearns, Antony, Dill, Brian D, Lee, Heyne, Flynn, Rowan, Cowley, Sally A, Davies, Paul, Lewis, Patrick A, Ganley, Ian G, Martinez, Jennifer, Alessi, Dario R, Reith, Alastair D, Trost, Matthias, Gutierrez, Maximiliano G
Publicado 2018