A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens

por Guna, Alina, Page, Katharine R., Replogle, Joseph M., Esantsi, Theodore K., Wang, Maxine L., Weissman, Jonathan S., Voorhees, Rebecca M.
Publicado 2023

A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens

por Guna, Alina, Page, Katharine R., Replogle, Joseph M., Esantsi, Theodore K., Wang, Maxine L., Weissman, Jonathan S., Voorhees, Rebecca M.
Publicado 2023

Nucleosomes impede Cas9 access to DNA in vivo and in vitro

por Horlbeck, Max A, Witkowsky, Lea B, Guglielmi, Benjamin, Replogle, Joseph M, Gilbert, Luke A, Villalta, Jacqueline E, Torigoe, Sharon E, Tjian, Robert, Weissman, Jonathan S
Publicado 2016

Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells

por Wu, David, Poddar, Aunoy, Ninou, Elpiniki, Hwang, Elizabeth, Cole, Mitchel A., Liu, S. John, Horlbeck, Max A., Chen, Jin, Replogle, Joseph M., Carosso, Giovanni A., Eng, Nicolas W.L., Chang, Jonghoon, Shen, Yin, Weissman, Jonathan S., Lim, Daniel A.
Publicado 2022

MTCH2 is a mitochondrial outer membrane protein insertase

por Guna, Alina, Stevens, Taylor A., Inglis, Alison J., Replogle, Joseph M., Esantsi, Theodore K., Muthukumar, Gayathri, Shaffer, Kelly C.L., Wang, Maxine L., Pogson, Angela N., Jones, Jeff J., Lomenick, Brett, Chou, Tsui-Fen, Weissman, Jonathan S., Voorhees, Rebecca M.
Publicado 2022

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

por Replogle, Joseph M., Saunders, Reuben A., Pogson, Angela N., Hussmann, Jeffrey A., Lenail, Alexander, Guna, Alina, Mascibroda, Lauren, Wagner, Eric J., Adelman, Karen, Lithwick-Yanai, Gila, Iremadze, Nika, Oberstrass, Florian, Lipson, Doron, Bonnar, Jessica L., Jost, Marco, Norman, Thomas M., Weissman, Jonathan S.
Publicado 2022

Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes

por Chan, Gail, White, Charles C., Winn, Phoebe A., Cimpean, Maria, Replogle, Joseph M., Glick, Laura R., Cuerdon, Nicole E., Ryan, Katie J., Johnson, Keith A., Schneider, Julie A., Bennett, David A., Chibnik, Lori B., Sperling, Reisa A., Bradshaw, Elizabeth M., De Jager, Philip L.
Publicado 2015

Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci

por Chan, Gail, White, Charles C., Winn, Phoebe A., Cimpean, Maria, Replogle, Joseph M., Glick, Laura R., Cuerdon, Nicole E., Ryan, Katie J., Johnson, Keith A., Schneider, Julie A., Bennett, David A., Chibnik, Lori B., Sperling, Reisa A., De Jager, Philip L., Bradshaw, Elizabeth M.
Publicado 2016

Genetic architecture of age-related cognitive decline in African Americans

por Raj, Towfique, Chibnik, Lori B., McCabe, Cristin, Wong, Andus, Replogle, Joseph M., Yu, Lei, Gao, Sujuan, Unverzagt, Frederick W., Stranger, Barbara, Murrell, Jill, Barnes, Lisa, Hendrie, Hugh C., Foroud, Tatiana, Krichevsky, Anna, Bennett, David A., Hall, Kathleen S., Evans, Denis A., De Jager, Philip L.
Publicado 2016

Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing

por Replogle, Joseph M., Norman, Thomas M., Xu, Albert, Hussmann, Jeffrey A., Chen, Jin, Cogan, J. Zachary, Meer, Elliott J., Terry, Jessica M., Riordan, Daniel P., Srinivas, Niranjan, Fiddes, Ian T., Arthur, Joseph G., Alvarado, Luigi J., Pfeiffer, Katherine A., Mikkelsen, Tarjei S., Weissman, Jonathan S., Adamson, Britt
Publicado 2020

Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors

por Replogle, Joseph M, Bonnar, Jessica L, Pogson, Angela N, Liem, Christina R, Maier, Nolan K, Ding, Yufang, Russell, Baylee J, Wang, Xingren, Leng, Kun, Guna, Alina, Norman, Thomas M, Pak, Ryan A, Ramos, Daniel M, Ward, Michael E, Gilbert, Luke A, Kampmann, Martin, Weissman, Jonathan S, Jost, Marco
Publicado 2022

Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq

por Sunshine, Sara, Puschnik, Andreas S., Replogle, Joseph M., Laurie, Matthew T., Liu, Jamin, Zha, Beth Shoshana, Nuñez, James K., Byrum, Janie R., McMorrow, Aidan H., Frieman, Matthew B., Winkler, Juliane, Qiu, Xiaojie, Rosenberg, Oren S., Leonetti, Manuel D., Ye, Chun Jimmie, Weissman, Jonathan S., DeRisi, Joseph L., Hein, Marco Y.
Publicado 2023

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

por Bentham, James, Morris, David L, Graham, Deborah S Cunninghame, Pinder, Christopher L, Tombleson, Philip, Behrens, Timothy W, Martín, Javier, Fairfax, Benjamin P, Knight, Julian C, Chen, Lingyan, Replogle, Joseph, Syvänen, Ann-Christine, Rönnblom, Lars, Graham, Robert R, Wither, Joan E, Rioux, John D, Alarcón-Riquelme, Marta E, Vyse, Timothy J
Publicado 2015

Mapping Transcriptomic Vector Fields of Single Cells

por Qiu, Xiaojie, Zhang, Yan, Martin-Rufino, Jorge D., Weng, Chen, Hosseinzadeh, Shayan, Yang, Dian, Pogson, Angela N., Hein, Marco Y., Min, Kyung Hoi (Joseph), Wang, Li, Grody, Emanuelle I., Shurtleff, Matthew J., Yuan, Ruoshi, Xu, Song, Ma, Yian, Replogle, Joseph M., Lander, Eric S., Darmanis, Spyros, Bahar, Ivet, Sankaran, Vijay G., Xing, Jianhua, Weissman, Jonathan S
Publicado 2022

Microfluidics-free single-cell genomics with templated emulsification

por Clark, Iain C., Fontanez, Kristina M., Meltzer, Robert H., Xue, Yi, Hayford, Corey, May-Zhang, Aaron, D’Amato, Chris, Osman, Ahmad, Zhang, Jesse Q., Hettige, Pabodha, Ishibashi, Jacob S. A., Delley, Cyrille L., Weisgerber, Daniel W., Replogle, Joseph M., Jost, Marco, Phong, Kiet T., Kennedy, Vanessa E., Peretz, Cheryl A. C., Kim, Esther A., Song, Siyou, Karlon, William, Weissman, Jonathan S., Smith, Catherine C., Gartner, Zev J., Abate, Adam R.
Publicado 2023

Rapid deployment of SARS-CoV-2 testing: The CLIAHUB

por Crawford, Emily D., Acosta, Irene, Ahyong, Vida, Anderson, Erika C., Arevalo, Shaun, Asarnow, Daniel, Axelrod, Shannon, Ayscue, Patrick, Azimi, Camillia S., Azumaya, Caleigh M., Bachl, Stefanie, Bachmutsky, Iris, Bhaduri, Aparna, Brown, Jeremy Bancroft, Batson, Joshua, Behnert, Astrid, Boileau, Ryan M., Bollam, Saumya R., Bonny, Alain R., Booth, David, Borja, Michael Jerico B., Brown, David, Buie, Bryan, Burnett, Cassandra E., Byrnes, Lauren E., Cabral, Katelyn A., Cabrera, Joana P., Caldera, Saharai, Canales, Gabriela, Castañeda, Gloria R., Chan, Agnes Protacio, Chang, Christopher R., Charles-Orszag, Arthur, Cheung, Carly, Chio, Unseng, Chow, Eric D., Citron, Y. Rose, Cohen, Allison, Cohn, Lillian B., Chiu, Charles, Cole, Mitchel A., Conrad, Daniel N., Constantino, Angela, Cote, Andrew, Crayton-Hall, Tre’Jon, Darmanis, Spyros, Detweiler, Angela M., Dial, Rebekah L., Dong, Shen, Duarte, Elias M., Dynerman, David, Egger, Rebecca, Fanton, Alison, Frumm, Stacey M., Fu, Becky Xu Hua, Garcia, Valentina E., Garcia, Julie, Gladkova, Christina, Goldman, Miriam, Gomez-Sjoberg, Rafael, Gordon, M. Grace, Grove, James C. R., Gupta, Shweta, Haddjeri-Hopkins, Alexis, Hadley, Pierce, Haliburton, John, Hao, Samantha L., Hartoularos, George, Herrera, Nadia, Hilberg, Melissa, Ho, Kit Ying E., Hoppe, Nicholas, Hosseinzadeh, Shayan, Howard, Conor J., Hussmann, Jeffrey A., Hwang, Elizabeth, Ingebrigtsen, Danielle, Jackson, Julia R., Jowhar, Ziad M., Kain, Danielle, Kim, James Y. S., Kistler, Amy, Kreutzfeld, Oriana, Kulsuptrakul, Jessie, Kung, Andrew F., Langelier, Charles, Laurie, Matthew T., Lee, Lena, Leng, Kun, Leon, Kristoffer E., Leonetti, Manuel D., Levan, Sophia R., Li, Sam, Li, Aileen W., Liu, Jamin, Lubin, Heidi S., Lyden, Amy, Mann, Jennifer, Mann, Sabrina, Margulis, Gorica, Marquez, Diana M., Marsh, Bryan P., Martyn, Calla, McCarthy, Elizabeth E., McGeever, Aaron, Merriman, Alexander F., Meyer, Lauren K., Miller, Steve, Moore, Megan K., Mowery, Cody T., Mukhtar, Tanzila, Mwakibete, Lusajo L., Narez, Noelle, Neff, Norma F., Osso, Lindsay A., Oviedo, Diter, Peng, Suping, Phelps, Maira, Phong, Kiet, Picard, Peter, Pieper, Lindsey M., Pincha, Neha, Pisco, Angela Oliveira, Pogson, Angela, Pourmal, Sergei, Puccinelli, Robert R., Puschnik, Andreas S., Rackaityte, Elze, Raghavan, Preethi, Raghavan, Madhura, Reese, James, Replogle, Joseph M., Retallack, Hanna, Reyes, Helen, Rose, Donald, Rosenberg, Marci F., Sanchez-Guerrero, Estella, Sattler, Sydney M., Savy, Laura, See, Stephanie K., Sellers, Kristin K., Serpa, Paula Hayakawa, Sheehy, Maureen, Sheu, Jonathan, Silas, Sukrit, Streithorst, Jessica A., Strickland, Jack, Stryke, Doug, Sunshine, Sara, Suslow, Peter, Sutanto, Renaldo, Tamura, Serena, Tan, Michelle, Tan, Jiongyi, Tang, Alice, Tato, Cristina M., Taylor, Jack C., Tenvooren, Iliana, Thompson, Erin M., Thornborrow, Edward C., Tse, Eric, Tung, Tony, Turner, Marc L., Turner, Victoria S., Turnham, Rigney E., Turocy, Mary J., Vaidyanathan, Trisha V., Vainchtein, Ilia D., Vanaerschot, Manu, Vazquez, Sara E., Wandler, Anica M., Wapniarski, Anne, Webber, James T., Weinberg, Zara Y., Westbrook, Alexandra, Wong, Allison W., Wong, Emily, Worthington, Gajus, Xie, Fang, Xu, Albert, Yamamoto, Terrina, Yang, Ying, Yarza, Fauna, Zaltsman, Yefim, Zheng, Tina, DeRisi, Joseph L.
Publicado 2020