Fc glycans of therapeutic antibodies as critical quality attributes

por Reusch, Dietmar, Tejada, Max L
Publicado 2015

High sensitivity glycomics in biomedicine

por Lageveen‐Kammeijer, Guinevere S. M., Kuster, Bernhard, Reusch, Dietmar, Wuhrer, Manfred
Publicado 2021

Discrepancies between High-Resolution Native and Glycopeptide-Centric Mass Spectrometric Approaches: A Case Study into the Glycosylation of Erythropoietin Variants

por Čaval, Tomislav, Buettner, Alexander, Haberger, Markus, Reusch, Dietmar, Heck, Albert J.R.
Publicado 2021

Affinity purification of erythropoietin from cell culture supernatant combined with MALDI-TOF-MS analysis of erythropoietin N-glycosylation

por Falck, David, Haberger, Markus, Plomp, Rosina, Hook, Michaela, Bulau, Patrick, Wuhrer, Manfred, Reusch, Dietmar
Publicado 2017

Affinity capillary electrophoresis – mass spectrometry permits direct binding assessment of IgG and FcγRIIa in a glycoform-resolved manner

por Gstöttner, Christoph, Knaupp, Alexander, Vidarsson, Gestur, Reusch, Dietmar, Schlothauer, Tilman, Wuhrer, Manfred, Domínguez-Vega, Elena
Publicado 2022

In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity

por Thomann, Marco, Schlothauer, Tilman, Dashivets, Tetyana, Malik, Sebastian, Avenal, Cecile, Bulau, Patrick, Rüger, Petra, Reusch, Dietmar
Publicado 2015

Interaction analysis of glycoengineered antibodies with CD16a: a native mass spectrometry approach

por Hajduk, Joanna, Brunner, Cyrill, Malik, Sebastian, Bangerter, Jana, Schneider, Gisbert, Thomann, Marco, Reusch, Dietmar, Zenobi, Renato
Publicado 2020

Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody

por Falck, David, Thomann, Marco, Lechmann, Martin, Koeleman, Carolien A. M., Malik, Sebastian, Jany, Cordula, Wuhrer, Manfred, Reusch, Dietmar
Publicado 2020

Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability

por Grunert, Ingrid, Heinrich, Katrin, Ernst, Juliane, Hingar, Michael, Briguet, Alexandre, Leiss, Michael, Wuhrer, Manfred, Reusch, Dietmar, Bulau, Patrick
Publicado 2022

Affinity Capillary Electrophoresis–Mass Spectrometry as a Tool to Unravel Proteoform-Specific Antibody–Receptor Interactions

por Gstöttner, Christoph, Hook, Michaela, Christopeit, Tony, Knaupp, Alexander, Schlothauer, Tilman, Reusch, Dietmar, Haberger, Markus, Wuhrer, Manfred, Domínguez-Vega, Elena
Publicado 2021

Identification of Potential Sites for Tryptophan Oxidation in Recombinant Antibodies Using tert-Butylhydroperoxide and Quantitative LC-MS

por Hensel, Miriam, Steurer, Rebecca, Fichtl, Juergen, Elger, Carsten, Wedekind, Frank, Petzold, Andreas, Schlothauer, Tilman, Molhoj, Michael, Reusch, Dietmar, Bulau, Patrick
Publicado 2011

Glycoform-resolved FcɣRIIIa affinity chromatography–mass spectrometry

por Lippold, Steffen, Nicolardi, Simone, Domínguez-Vega, Elena, Heidenreich, Anna-Katharina, Vidarsson, Gestur, Reusch, Dietmar, Haberger, Markus, Wuhrer, Manfred, Falck, David
Publicado 2019

The Impact of Immunoglobulin G1 Fc Sialylation on Backbone Amide H/D Exchange

por Kuhne, Felix, Bonnington, Lea, Malik, Sebastian, Thomann, Marco, Avenal, Cecile, Cymer, Florian, Wegele, Harald, Reusch, Dietmar, Mormann, Michael, Bulau, Patrick
Publicado 2019

Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model

por Falck, David, Lechmann, Martin, Momčilović, Ana, Thomann, Marco, Koeleman, Carolien A. M., Jany, Cordula, Malik, Sebastian, Wuhrer, Manfred, Reusch, Dietmar
Publicado 2022

Characterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody

por Cramer, Dario A. T., Franc, Vojtech, Heidenreich, Anna-Katharina, Hook, Michaela, Adibzadeh, Mahdi, Reusch, Dietmar, Heck, Albert J. R., Haberger, Markus
Publicado 2023

Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 2: Mass spectrometric methods

por Reusch, Dietmar, Haberger, Markus, Falck, David, Peter, Britta, Maier, Bernd, Gassner, Jana, Hook, Michaela, Wagner, Katharina, Bonnington, Lea, Bulau, Patrick, Wuhrer, Manfred
Publicado 2015

Comprehensive Multidimensional Liquid Chromatography–Mass Spectrometry for the Characterization of Charge Variants of a Bispecific Antibody

por Grunert, Ingrid, Heinrich, Katrin, Hingar, Michael, Ernst, Juliane, Winter, Martin, Bomans, Katrin, Wagner, Katharina, Fevre, Arnaud, Reusch, Dietmar, Wuhrer, Manfred, Bulau, Patrick
Publicado 2022

Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry

por Haberger, Markus, Leiss, Michael, Heidenreich, Anna-Katharina, Pester, Oxana, Hafenmair, Georg, Hook, Michaela, Bonnington, Lea, Wegele, Harald, Haindl, Markus, Reusch, Dietmar, Bulau, Patrick
Publicado 2015

Simultaneous Assessment of Asp Isomerization and Asn Deamidation in Recombinant Antibodies by LC-MS following Incubation at Elevated Temperatures

por Diepold, Katharina, Bomans, Katrin, Wiedmann, Michael, Zimmermann, Boris, Petzold, Andreas, Schlothauer, Tilman, Mueller, Robert, Moritz, Bernd, Stracke, Jan Olaf, Mølhøj, Michael, Reusch, Dietmar, Bulau, Patrick
Publicado 2012

Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 1: Separation-based methods

por Reusch, Dietmar, Haberger, Markus, Maier, Bernd, Maier, Maria, Kloseck, Ronny, Zimmermann, Boris, Hook, Michaela, Szabo, Zoltan, Tep, Samnang, Wegstein, Jo, Alt, Nadja, Bulau, Patrick, Wuhrer, Manfred
Publicado 2014