Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes

por Tanowitz, Michael, Hettrick, Lisa, Revenko, Alexey, Kinberger, Garth A., Prakash, Thazha P., Seth, Punit P.
Publicado 2017

Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides

por Wang, Shiyu, Allen, Nickolas, Vickers, Timothy A, Revenko, Alexey S, Sun, Hong, Liang, Xue-hai, Crooke, Stanley T
Publicado 2018

CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway

por Sanderlin, Edward J., Keenan, Melissa M., Mense, Martin, Revenko, Alexey S., Monia, Brett P., Guo, Shuling, Huang, Lulu
Publicado 2022

Histidine-rich glycoprotein attenuates catheter thrombosis

por Malik, Rida A., Liao, Peng, Zhou, Ji, Hussain, Rawaa, Fredenburgh, James C., Hettrick, Lisa, Revenko, Alexey S., Weitz, Jeffrey I.
Publicado 2023

Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines

por Linnane, Emily, Davey, Paul, Zhang, Pei, Puri, Sanyogitta, Edbrooke, Mark, Chiarparin, Elisabetta, Revenko, Alexey S, Macleod, A Robert, Norman, Jim C, Ross, Sarah J
Publicado 2019

The contact system proteases play disparate roles in streptococcal sepsis

por Köhler, Juliane, Maletzki, Claudia, Koczan, Dirk, Frank, Marcus, Trepesch, Carolin, Revenko, Alexey S., Crosby, Jeffrey R., Macleod, A. Robert, Mikkat, Stefan, Oehmcke-Hecht, Sonja
Publicado 2020

Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis

por Köhler, Juliane, Maletzki, Claudia, Koczan, Dirk, Frank, Marcus, Springer, Armin, Steffen, Carolin, Revenko, Alexey S., MacLeod, A.Robert, Mikkat, Stefan, Kreikemeyer, Bernd, Oehmcke-Hecht, Sonja
Publicado 2020

Plasmin drives burn-induced systemic inflammatory response syndrome

por Gibson, Breanne H. Y., Wollenman, Colby C., Moore-Lotridge, Stephanie N., Keller, Patrick R., Summitt, J. Blair, Revenko, Alexey R., Flick, Matthew J., Blackwell, Timothy S., Schoenecker, Jonathan G.
Publicado 2021

Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics

por Finicle, Brendan T, Eckenstein, Kazumi H, Revenko, Alexey S, Anderson, Brooke A, Wan, W Brad, McCracken, Alison N, Gil, Daniel, Fruman, David A, Hanessian, Stephen, Seth, Punit P, Edinger, Aimee L
Publicado 2023

Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation

por Tweddell, James S., Kharnaf, Mousa, Zafar, Farhan, Riggs, Kyle W., Reagor, James A., Monia, Brett P., Revenko, Alexey, Leino, Daniel G., Owens, A. Phillip, Martin, Janine K., Gourley, Benjamin, Rosenfeldt, Leah, Palumbo, Joseph S.
Publicado 2022

Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice

por Ding, Chao, Scicluna, Brendon P, Stroo, Ingrid, Yang, Jack, Roelofs, Joris JTH, de Boer, Onno J, de Vos, Alex F, Nürnberg, Peter, Revenko, Alexey S, Crosby, Jeff, van't Veer, Cornelis, van der Poll, Tom
Publicado 2019

Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling

por Kapustin, Alexander N., Davey, Paul, Longmire, David, Matthews, Carl, Linnane, Emily, Rustogi, Nitin, Stavrou, Maria, Devine, Paul W. A., Bond, Nicholas J., Hanson, Lyndsey, Sonzini, Silvia, Revenko, Alexey, MacLeod, A. Robert, Ross, Sarah, Chiarparin, Elisabetta, Puri, Sanyogitta
Publicado 2021

IONIS-PKK(Rx) a Novel Antisense Inhibitor of Prekallikrein and Bradykinin Production

por Ferrone, Jason D., Bhattacharjee, Gourab, Revenko, Alexey S., Zanardi, Thomas A., Warren, Marshelle S., Derosier, Frederick J., Viney, Nicholas J., Pham, Nguyen C., Kaeser, Gwendolyn E., Baker, Brenda F., Schneider, Eugene, Hughes, Steven G., Monia, Brett P., MacLeod, A. Robert
Publicado 2019

Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer

por Revenko, Alexey, Carnevalli, Larissa S, Sinclair, Charles, Johnson, Ben, Peter, Alison, Taylor, Molly, Hettrick, Lisa, Chapman, Melissa, Klein, Stephanie, Solanki, Anisha, Gattis, Danielle, Watt, Andrew, Hughes, Adina M, Magiera, Lukasz, Kar, Gozde, Ireland, Lucy, Mele, Deanna A, Sah, Vasu, Singh, Maneesh, Walton, Josephine, Mairesse, Maelle, King, Matthew, Edbrooke, Mark, Lyne, Paul, Barry, Simon T, Fawell, Stephen, Goldberg, Frederick W, MacLeod, A Robert
Publicado 2022

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial.

por Reilley, Matthew J., McCoon, Patricia, Cook, Carl, Lyne, Paul, Kurzrock, Razelle, Kim, Youngsoo, Woessner, Richard, Younes, Anas, Nemunaitis, John, Fowler, Nathan, Curran, Michael, Liu, Qinying, Zhou, Tianyuan, Schmidt, Joanna, Jo, Minji, Lee, Samantha J., Yamashita, Mason, Hughes, Steven G., Fayad, Luis, Piha-Paul, Sarina, Nadella, Murali V. P., Xiao, Xiaokun, Hsu, Jeff, Revenko, Alexey, Monia, Brett P., MacLeod, A. Robert, Hong, David S.
Publicado 2018