Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease

por Rajamohan, Francis, Reyes, Allan R., Tu, Meihua, Nedoma, Nicole L., Hoth, Lise R., Schwaid, Adam G., Kurumbail, Ravi G., Ward, Jessica, Han, Seungil
Publicado 2020

Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological a...

por Rajamohan, Francis, Reyes, Allan R., Frisbie, Richard K., Hoth, Lise R., Sahasrabudhe, Parag, Magyar, Rachelle, Landro, James A., Withka, Jane M., Caspers, Nicole L., Calabrese, Matthew F., Ward, Jessica, Kurumbail, Ravi G.
Publicado 2016

Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors

por Liu, Shenping, Kormos, Bethany L., Knafels, John D., Sahasrabudhe, Parag V., Rosado, Amy, Sommese, Ruth F., Reyes, Allan R., Ward, Jessica, Roth Flach, Rachel J., Wang, Xiaochun, Buzon, Leanne M., Reese, Matthew R., Bhattacharya, Samit K., Omoto, Kiyoyuki, Filipski, Kevin J.
Publicado 2023

Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels

por Roth Flach, Rachel J., Bollinger, Eliza, Reyes, Allan R., Laforest, Brigitte, Kormos, Bethany L., Liu, Shenping, Reese, Matthew R., Martinez Alsina, Luis A., Buzon, Leanne, Zhang, Yuan, Bechle, Bruce, Rosado, Amy, Sahasrabudhe, Parag V., Knafels, John, Bhattacharya, Samit K., Omoto, Kiyoyuki, Stansfield, John C., Hurley, Liam D., Song, LouJin, Luo, Lina, Breitkopf, Susanne B., Monetti, Mara, Cunio, Teresa, Tierney, Brendan, Geoly, Frank J., Delmore, Jake, Siddall, C. Parker, Xue, Liang, Yip, Ka N., Kalgutkar, Amit S., Miller, Russell A., Zhang, Bei B., Filipski, Kevin J.
Publicado 2023