Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor

por Reyes-Alcaraz, Arfaxad, Lee, Yoo-Na, Yun, Seongsik, Hwang, Jong-Ik, Seong, Jae Young
Publicado 2018

Exploring the molecular structures that confer ligand selectivity for galanin type II and III receptors

por Lee, Yoo-Na, Reyes-Alcaraz, Arfaxad, Yun, Seongsik, Lee, Cheol Soon, Hwang, Jong-Ik, Seong, Jae Young
Publicado 2020

Fusion of the β(2)‐adrenergic receptor with either Gαs or βarrestin‐2 produces constitutive signaling by each pathway and induces gain‐of‐function in BEAS‐2B cells

por Lucero‐Garcia Rojas, Emilio Y., Reyes‐Alcaraz, Arfaxad, Ruan, Kehe, McConnell, Bradley K., Bond, Richard A.
Publicado 2022

A NanoBiT assay to monitor membrane proteins trafficking for drug discovery and drug development

por Reyes-Alcaraz, Arfaxad, Lucero Garcia-Rojas, Emilio Y., Merlinsky, Elizabeth A., Seong, Jae Young, Bond, Richard A., McConnell, Bradley K.
Publicado 2022

A Small Molecule That In Vitro Neutralizes Infection of SARS-CoV-2 and Its Most Infectious Variants, Delta, and Omicron

por Reyes-Alcaraz, Arfaxad, Qasim, Hanan, Merlinsky, Elizabeth, Fox, Glenn, Islam, Tasneem, Medina, Bryan, Schwartz, Robert J., Craft, John W., McConnell, Bradley K.
Publicado 2023

Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice

por Reyes-Alcaraz, Arfaxad, Lee, Yoo-Na, Son, Gi Hoon, Kim, Nam Hoon, Kim, Dong-Kyu, Yun, Seongsik, Kim, Dong-Hoon, Hwang, Jong-Ik, Seong, Jae Young
Publicado 2016

CXCR7: a β-arrestin-biased receptor that potentiates cell migration and recruits β-arrestin2 exclusively through Gβγ subunits and GRK2

por Nguyen, Huong Thi, Reyes-Alcaraz, Arfaxad, Yong, Hyo Jeong, Nguyen, Lan Phuong, Park, Hee-Kyung, Inoue, Asuka, Lee, Cheol Soon, Seong, Jae Young, Hwang, Jong-Ik
Publicado 2020

Direct reprogramming of cardiomyocytes into cardiac Purkinje-like cells

por Prodan, Nicole, Ershad, Faheem, Reyes-Alcaraz, Arfaxad, Li, Luge, Mistretta, Brandon, Gonzalez, Lei, Rao, Zhoulyu, Yu, Cunjiang, Gunaratne, Preethi H., Li, Na, Schwartz, Robert J., McConnell, Bradley K.
Publicado 2022

Establishment of a NanoBiT-Based Cytosolic Ca(2+) Sensor by Optimizing Calmodulin-Binding Motif and Protein Expression Levels

por Nguyen, Lan Phuong, Nguyen, Huong Thi, Yong, Hyo Jeong, Reyes-Alcaraz, Arfaxad, Lee, Yoo-Na, Park, Hee-Kyung, Na, Yun Hee, Lee, Cheol Soon, Ham, Byung-Joo, Seong, Jae Young, Hwang, Jong-Ik
Publicado 2020

Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight

por Yun, Seongsik, Reyes-Alcaraz, Arfaxad, Lee, Yoo-Na, Yong, Hyo Jeong, Choi, Jeewon, Ham, Byung-Joo, Sohn, Jong-Woo, Kim, Dong-Hoon, Son, Gi Hoon, Kim, Hyun, Kwon, Soon-Gu, Kim, Dong Sik, Kim, Bong Chul, Hwang, Jong-Ik, Seong, Jae Young
Publicado 2019