Supervised molecular dynamics for exploring the druggability of the SARS-CoV-2 spike protein

por Deganutti, Giuseppe, Prischi, Filippo, Reynolds, Christopher A.
Publicado 2020

Is the Stalk of the SARS-CoV-2 Spike Protein Druggable?

por Pipitò, Ludovico, Reynolds, Christopher A., Deganutti, Giuseppe
Publicado 2022

Molecular dynamics studies reveal structural and functional features of the SARS‐CoV‐2 spike protein

por Pipitò, Ludovico, Rujan, Roxana‐Maria, Reynolds, Christopher A., Deganutti, Giuseppe
Publicado 2022

A Pathway Model to Understand the Evolution of Spike Protein Binding to ACE2 in SARS-CoV-2 Variants

por Pipitò, Ludovico, Reynolds, Christopher A., Mobarec, Juan Carlos, Vickery, Owen, Deganutti, Giuseppe
Publicado 2022

High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH(2)) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5

por Weaver, Richard E., Mobarec, Juan C., Wigglesworth, Mark J., Reynolds, Christopher A., Donnelly, Dan
Publicado 2017

Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors

por Deganutti, Giuseppe, Atanasio, Silvia, Rujan, Roxana-Maria, Sexton, Patrick M., Wootten, Denise, Reynolds, Christopher A.
Publicado 2021

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP...

por Koole, Cassandra, Reynolds, Christopher A., Mobarec, Juan C., Hick, Caroline, Sexton, Patrick M., Sakmar, Thomas P.
Publicado 2017

Assessing the effect of dynamics on the closed-loop protein-folding hypothesis

por Chintapalli, Sree V., Illingworth, Christopher J. R., Upton, Graham J. G., Sacquin-Mora, Sophie, Reeves, Philip J., Mohammedali, Hani S., Reynolds, Christopher A.
Publicado 2014

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in...

por Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Furness, Sebastian G.B., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado 2016

The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation

por Winfield, Ian, Barkan, Kerry, Routledge, Sarah, Robertson, Nathan J., Harris, Matthew, Jazayeri, Ali, Simms, John, Reynolds, Christopher A., Poyner, David R., Ladds, Graham
Publicado 2022

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies

por Vohra, Shabana, Taddese, Bruck, Conner, Alex C., Poyner, David R., Hay, Debbie L., Barwell, James, Reeves, Philip J., Upton, Graham J. G., Reynolds, Christopher A.
Publicado 2013

Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs

por Woolley, Michael J., Reynolds, Christopher A., Simms, John, Walker, Christopher S., Mobarec, Juan Carlos, Garelja, Michael L., Conner, Alex C., Poyner, David R., Hay, Debbie L.
Publicado 2017

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach

por Woolley, Michael. J., Watkins, Harriet A., Taddese, Bruck, Karakullukcu, Z. Gamze, Barwell, James, Smith, Kevin J., Hay, Debbie L., Poyner, David R., Reynolds, Christopher A., Conner, Alex C.
Publicado 2013

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors

por Weston, Cathryn, Winfield, Ian, Harris, Matthew, Hodgson, Rose, Shah, Archna, Dowell, Simon J., Mobarec, Juan Carlos, Woodlock, David A., Reynolds, Christopher A., Poyner, David R., Watkins, Harriet A., Ladds, Graham
Publicado 2016

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2)

por Weston, Cathryn, Lu, Jing, Li, Naichang, Barkan, Kerry, Richards, Gareth O., Roberts, David J., Skerry, Timothy M., Poyner, David, Pardamwar, Meenakshi, Reynolds, Christopher A., Dowell, Simon J., Willars, Gary B., Ladds, Graham
Publicado 2015

Understanding VPAC receptor family peptide binding and selectivity

por Piper, Sarah J., Deganutti, Giuseppe, Lu, Jessica, Zhao, Peishen, Liang, Yi-Lynn, Lu, Yao, Fletcher, Madeleine M., Hossain, Mohammed Akhter, Christopoulos, Arthur, Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M., Wootten, Denise
Publicado 2022

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

por Dal Maso, Emma, Zhu, Yue, Pham, Vi, Reynolds, Christopher A., Deganutti, Giuseppe, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Wang, Ming-Wei, Sexton, Patrick M., Furness, Sebastian G.B., Wootten, Denise
Publicado 2018

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

por Liang, Yi-Lynn, Khoshouei, Maryam, Deganutti, Giuseppe, Glukhova, Alisa, Koole, Cassandra, Peat, Thomas S., Radjainia, Mazdak, Plitzko, Jürgen M., Baumeister, Wolfgang, Miller, Laurence J., Hay, Deborah L., Christopoulos, Arthur, Reynolds, Christopher A, Wootten, Denise, Sexton, Patrick M.
Publicado 2018

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

por Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Koole, Cassandra, Savage, Emilia E., Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G.B., Liu, Mengjie, Thompson, Philip E., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado 2016

Structure and dynamics of the active Gs-coupled human secretin receptor

por Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M., Miller, Laurence J.
Publicado 2020