The Role of Post-Translational Modifications on Prion-Like Aggregation and Liquid-Phase Separation of FUS

por Rhoads, Shannon N., Monahan, Zachary T., Yee, Debra S., Shewmaker, Frank P.
Publicado 2018

Yeast Models of Prion-Like Proteins That Cause Amyotrophic Lateral Sclerosis Reveal Pathogenic Mechanisms

por Monahan, Zachary T., Rhoads, Shannon N., Yee, Debra S., Shewmaker, Frank P.
Publicado 2018

The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions

por Owen, Izzy, Rhoads, Shannon, Yee, Debra, Wyne, Hala, Gery, Kevin, Hannula, Isabelle, Sundrum, Meenakshi, Shewmaker, Frank
Publicado 2020

The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization

por Rhoads, Shannon N., Monahan, Zachary T., Yee, Debra S., Leung, Andrew Y., Newcombe, Cameron G., O’Meally, Robert N., Cole, Robert N., Shewmaker, Frank P.
Publicado 2018

A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing

por Wang, Ailin, Conicella, Alexander E, Schmidt, Hermann Broder, Martin, Erik W, Rhoads, Shannon N, Reeb, Ashley N, Nourse, Amanda, Ramirez Montero, Daniel, Ryan, Veronica H, Rohatgi, Rajat, Shewmaker, Frank, Naik, Mandar T, Mittag, Tanja, Ayala, Yuna M, Fawzi, Nicolas L
Publicado 2018

Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity

por Monahan, Zachary, Ryan, Veronica H, Janke, Abigail M, Burke, Kathleen A, Rhoads, Shannon N, Zerze, Gül H, O'Meally, Robert, Dignon, Gregory L, Conicella, Alexander E, Zheng, Wenwei, Best, Robert B, Cole, Robert N, Mittal, Jeetain, Shewmaker, Frank, Fawzi, Nicolas L
Publicado 2017