An observational, non-interventional study for the follow-up of patients with amyloidosis who received miridesap followed by dezamizumab in a phase 1 study

por Richards, Duncan, Millns, Helen, Cookson, Louise, Lukas, Mary Ann
Publicado 2022

Accumulating evidence suggests anti-TNF therapy needs to be given trial priority in COVID-19 treatment

por Robinson, Philip C, Richards, Duncan, Tanner, Helen L, Feldmann, Marc
Publicado 2020

In vivo human keyhole limpet hemocyanin challenge in early phase drug development: A systematic review

por Drennan, Philip G., Karponis, Dimitrios, Richards, Duncan, Coles, Mark, Fullerton, James N.
Publicado 2022

Base of thumb osteoarthritis in UK interface services—a cohort and survey-based study to assess current practice

por Dean, Benjamin J F, Kluzek, Stefan, Carr, Andrew J, Hopewell, Sally, Richards, Duncan, Riley, Nicholas, Cuff, Andrew
Publicado 2020

Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed

por Feldmann, Marc, Maini, Ravinder N, Woody, James N, Holgate, Stephen T, Winter, Gregory, Rowland, Matthew, Richards, Duncan, Hussell, Tracy
Publicado 2020

The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19

por Robinson, Philip C., Liew, David F.L., Liew, Jean W., Monaco, Claudia, Richards, Duncan, Shivakumar, Senthuran, Tanner, Helen L., Feldmann, Marc
Publicado 2020

Safety, Tolerability and Pharmacokinetics of Single Doses of Oxytocin Administered via an Inhaled Route in Healthy Females: Randomized, Single-blind, Phase 1 Study()

por Fernando, Disala, Siederer, Sarah, Singh, Sunita, Schneider, Ian, Gupta, Ashutosh, Powell, Marcy, Richards, Duncan, McIntosh, Michelle P., Lambert, Peter, Fowles, Susan
Publicado 2017

A multi-centre open-label two-arm randomised superiority clinical trial of azithromycin versus usual care in ambulatory COVID-19: study protocol for the ATOMIC2 trial

por Hinks, Timothy S. C., Barber, Vicki S., Black, Joanna, Dutton, Susan J., Jabeen, Maisha, Melhorn, James, Rahman, Najib M, Richards, Duncan, Lasserson, Daniel, Pavord, Ian D., Bafadhel, Mona
Publicado 2020

A randomized, double‐blind, placebo‐controlled trial of camicinal in Parkinson's disease

por Marrinan, Sarah L., Otiker, Tal, Vasist, Lakshmi S., Gibson, Rachel A., Sarai, Bhopinder K., Barton, Matthew E., Richards, Duncan B., Hellström, Per M., Nyholm, Dag, Dukes, George E., Burn, David J.
Publicado 2017

The effect of camicinal (GSK962040), a motilin agonist, on gastric emptying and glucose absorption in feed-intolerant critically ill patients: a randomized, blinded, placebo-contro...

por Chapman, Marianne J., Deane, Adam M., O’Connor, Stephanie L., Nguyen, Nam Q., Fraser, Robert J. L., Richards, Duncan B., Hacquoil, Kimberley E., Vasist Johnson, Lakshmi S., Barton, Matthew E., Dukes, George E.
Publicado 2016

BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial

por Hegade, Vinod S., Kendrick, Stuart F. W., Dobbins, Robert L., Miller, Sam R., Richards, Duncan, Storey, James, Dukes, George, Gilchrist, Kim, Vallow, Susan, Alexander, Graeme J., Corrigan, Margaret, Hirschfield, Gideon M., Jones, David E. J.
Publicado 2016

COVID-19 therapeutics: Challenges and directions for the future

por Robinson, Philip C., Liew, David F. L., Tanner, Helen L., Grainger, John R., Dwek, Raymond A., Reisler, Ronald B., Steinman, Lawrence, Feldmann, Marc, Ho, Ling-Pei, Hussell, Tracy, Moss, Paul, Richards, Duncan, Zitzmann, Nicole
Publicado 2022

CATALYST trial protocol: a multicentre, open-label, phase II, multiarm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults

por Veenith, Tonny, Fisher, Benjamin A., Slade, Daniel, Rowe, Anna, Sharpe, Rowena, Thickett, David R., Whitehouse, Tony, Rowland, Matthew, Scriven, James, Parekh, Dhruv, Bowden, Sarah J., Savage, Joshua S., Richards, Duncan, Bion, Julian, Kearns, Pamela, Gates, Simon
Publicado 2021

Optimising psoriatic arthritis therapy with immunological methods to increase standard evaluation: the protocol of an open-label multicentre, parallel-group, two-arm randomised con...

por Ooms, Alexander, Al-Mossawi, Hussein, Bennett, Louise, Bogale, Mimi, Bowness, Paul, Francis, Anne, Goodyear, Carl, Kirkham, Bruce W, Lalnunhlimi, Sylvine, McInnes, Iain B, Richards, Duncan, Siebert, Stefan, Taams, Leonie S, Tulunay Virlan, Aysin, Yager, Nicole, Coates, Laura C
Publicado 2023

The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects

por Ziauddeen, Hisham, Nathan, Pradeep J, Dodds, Chris, Maltby, Kay, Miller, Sam R, Waterworth, Dawn, Song, Kijoung, Warren, Liling, Hosking, Louise, Zucchetto, Mauro, Bush, Mark, Johnson, Lakshmi Vasist, Sarai, Bhopinder, Mogg, Karin, Bradley, Brendan P, Richards, Duncan B, Fletcher, Paul C, Bullmore, Edward T
Publicado 2013

Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype

por Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Vasist Johnson, Lakshmi, Fletcher, Paul C, Bullmore, Edward T
Publicado 2016

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy

por Babinsky, Valerie N., Hannan, Fadil M., Ramracheya, Reshma D., Zhang, Quan, Nesbit, M. Andrew, Hugill, Alison, Bentley, Liz, Hough, Tertius A., Joynson, Elizabeth, Stewart, Michelle, Aggarwal, Abhishek, Prinz-Wohlgenannt, Maximilian, Gorvin, Caroline M., Kallay, Enikö, Wells, Sara, Cox, Roger D., Richards, Duncan, Rorsman, Patrik, Thakker, Rajesh V.
Publicado 2017

Azithromycin versus standard care in patients with mild-to-moderate COVID-19 (ATOMIC2): an open-label, randomised trial

por Hinks, Timothy S C, Cureton, Lucy, Knight, Ruth, Wang, Ariel, Cane, Jennifer L, Barber, Vicki S, Black, Joanna, Dutton, Susan J, Melhorn, James, Jabeen, Maisha, Moss, Phil, Garlapati, Rajendar, Baron, Tanya, Johnson, Graham, Cantle, Fleur, Clarke, David, Elkhodair, Samer, Underwood, Jonathan, Lasserson, Daniel, Pavord, Ian D, Morgan, Sophie, Richards, Duncan
Publicado 2021

Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial

por Dorward, Jienchi, Yu, Ly-Mee, Hayward, Gail, Saville, Benjamin R, Gbinigie, Oghenekome, Van Hecke, Oliver, Ogburn, Emma, Evans, Philip H, Thomas, Nicholas PB, Patel, Mahendra G, Richards, Duncan, Berry, Nicholas, Detry, Michelle A, Saunders, Christina, Fitzgerald, Mark, Harris, Victoria, Shanyinde, Milensu, de Lusignan, Simon, Andersson, Monique I, Butler, Christopher C, Hobbs, FD Richard
Publicado 2022

Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, ph...

por Fisher, Benjamin A, Veenith, Tonny, Slade, Daniel, Gaskell, Charlotte, Rowland, Matthew, Whitehouse, Tony, Scriven, James, Parekh, Dhruv, Balasubramaniam, Madhu S, Cooke, Graham, Morley, Nick, Gabriel, Zoe, Wise, Matthew P, Porter, Joanna, McShane, Helen, Ho, Ling-Pei, Newsome, Philip N, Rowe, Anna, Sharpe, Rowena, Thickett, David R, Bion, Julian, Gates, Simon, Richards, Duncan, Kearns, Pamela
Publicado 2022