Understanding the Complexity of Porous Graphitic Carbon (PGC) Chromatography: Modulation of Mobile-Stationary Phase Interactions Overcomes Loss of Retention and Reduces Variability

por Bapiro, Tashinga E., Richards, Frances M., Jodrell, Duncan I.
Publicado 2016

Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model In Vivo

por Richards, Frances M., Tape, Christopher J., Jodrell, Duncan I., Murphy, Gillian
Publicado 2012

Modelling of the cancer cell cycle as a tool for rational drug development: A systems pharmacology approach to cyclotherapy

por Jackson, Robert C., Di Veroli, Giovanni Y., Koh, Siang-Boon, Goldlust, Ian, Richards, Frances M., Jodrell, Duncan I.
Publicado 2017

Combenefit: an interactive platform for the analysis and visualization of drug combinations

por Di Veroli, Giovanni Y., Fornari, Chiara, Wang, Dennis, Mollard, Séverine, Bramhall, Jo L., Richards, Frances M., Jodrell, Duncan I.
Publicado 2016

An automated fitting procedure and software for dose-response curves with multiphasic features

por Veroli, Giovanni Y. Di, Fornari, Chiara, Goldlust, Ian, Mills, Graham, Koh, Siang Boon, Bramhall, Jo L, Richards, Frances M., Jodrell, Duncan I.
Publicado 2015

Anti-Tumour Efficacy of Capecitabine in a Genetically Engineered Mouse Model of Pancreatic Cancer

por Courtin, Aurélie, Richards, Frances M., Bapiro, Tashinga E., Bramhall, Jo L., Neesse, Albrecht, Cook, Natalie, Krippendorff, Ben-Fillippo, Tuveson, David A., Jodrell, Duncan I.
Publicado 2013

SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice

por Neesse, Albrecht, Frese, Kristopher K, Chan, Derek S, Bapiro, Tashinga E, Howat, William J, Richards, Frances M, Ellenrieder, Volker, Jodrell, Duncan I, Tuveson, David A
Publicado 2014

Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models

por Dunlop, Charles R., Wallez, Yann, Johnson, Timothy Isaac, Bernaldo de Quirós Fernández, Sandra, Durant, Stephen T., Cadogan, Elaine B., Lau, Alan, Richards, Frances M., Jodrell, Duncan I.
Publicado 2020

Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer

por Buchholz, Soeren M., Goetze, Robert G., Singh, Shiv K., Ammer-Herrmenau, Christoph, Richards, Frances M., Jodrell, Duncan I., Buchholz, Malte, Michl, Patrick, Ellenrieder, Volker, Hessmann, Elisabeth, Neesse, Albrecht
Publicado 2020

Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach

por Johnson, Timothy I., Minteer, Christopher J., Kottmann, Daniel, Dunlop, Charles R., Fernández, Sandra Bernaldo de Quirós, Carnevalli, Larissa S., Wallez, Yann, Lau, Alan, Richards, Frances M., Jodrell, Duncan I.
Publicado 2021

SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer

por Ramu, Iswarya, Buchholz, Sören M., Patzak, Melanie S., Goetze, Robert G., Singh, Shiv K., Richards, Frances M., Jodrell, Duncan I., Sipos, Bence, Ströbel, Philipp, Ellenrieder, Volker, Hessmann, Elisabeth, Neesse, Albrecht
Publicado 2019

Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes

por Watts, Ciorsdaidh A., Richards, Frances M., Bender, Andreas, Bond, Peter J., Korb, Oliver, Kern, Oliver, Riddick, Michelle, Owen, Paul, Myers, Rebecca M., Raff, Jordan, Gergely, Fanni, Jodrell, Duncan I., Ley, Steven V.
Publicado 2013

Anti‐stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma

por Carapuça, Elisabete F, Gemenetzidis, Emilios, Feig, Christine, Bapiro, Tashinga E, Williams, Michael D, Wilson, Abigail S, Delvecchio, Francesca R, Arumugam, Prabhu, Grose, Richard P, Lemoine, Nicholas R, Richards, Frances M, Kocher, Hemant M
Publicado 2016

Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancer

por Popov, Andrea Bistrović, Melle, Francesca, Linnane, Emily, González-López, Cristina, Ahmed, Ishtiaq, Parshad, Badri, Franck, Christoph O., Rahmoune, Hassan, Richards, Frances M., Muñoz-Espín, Daniel, Jodrell, Duncan I., Fairen-Jimenez, David, Fruk, Ljiljana
Publicado 2022

A novel method for quantification of gemcitabine and its metabolites 2′,2′-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC–MS/MS: comparison with (19)F NMR...

por Bapiro, Tashinga E., Richards, Frances M., Goldgraben, Mae A., Olive, Kenneth P., Madhu, Basetti, Frese, Kristopher K., Cook, Natalie, Jacobetz, Michael A., Smith, Donna-Michelle, Tuveson, David A., Griffiths, John R., Jodrell, Duncan I.
Publicado 2011

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites

por Patzak, Melanie S., Kari, Vijayalakshmi, Patil, Shilpa, Hamdan, Feda H., Goetze, Robert G., Brunner, Marius, Gaedcke, Jochen, Kitz, Julia, Jodrell, Duncan I., Richards, Frances M., Pilarsky, Christian, Gruetzmann, Robert, Rümmele, Petra, Knösel, Thomas, Hessmann, Elisabeth, Ellenrieder, Volker, Johnsen, Steven A., Neesse, Albrecht
Publicado 2019

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

por Sale, Matthew J., Minihane, Emma, Monks, Noel R., Gilley, Rebecca, Richards, Frances M., Schifferli, Kevin P., Andersen, Courtney L., Davies, Emma J., Vicente, Mario Aladren, Ozono, Eiko, Markovets, Aleksandra, Dry, Jonathan R., Drew, Lisa, Flemington, Vikki, Proia, Theresa, Jodrell, Duncan I., Smith, Paul D., Cook, Simon J.
Publicado 2019

Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

por Graziano, Vincenzo, Dannhorn, Andreas, Hulme, Heather, Williamson, Kate, Buckley, Hannah, Karim, Saadia A, Wilson, Matthew, Lee, Sheng Y, Kaistha, Brajesh P, Islam, Sabita, Thaventhiran, James E D, Richards, Frances M, Goodwin, Richard, Brais, Rebecca, Morton, Jennifer P, Dovedi, Simon J, Schuller, Alwin G, Eyles, Jim, Jodrell, Duncan I
Publicado 2023

T Cell–Mediated Antitumor Immunity Cooperatively Induced By TGFβR1 Antagonism and Gemcitabine Counteracts Reformation of the Stromal Barrier in Pancreatic Cancer

por Li, Dandan, Schaub, Nicholas, Guerin, Theresa M., Bapiro, Tashinga E., Richards, Frances M., Chen, Vicky, Talsania, Keyur, Kumar, Parimal, Gilbert, Debra J., Schlomer, Jerome J., Kim, Seong-Jin, Sorber, Rebecca, Teper, Yaroslav, Bautista, Wendy, Palena, Claudia, Ock, Chan-Young, Jodrell, Duncan I., Pate, Nathan, Mehta, Monika, Zhao, Yongmei, Kozlov, Serguei, Rudloff, Udo
Publicado 2021

Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment

por Roy-Luzarraga, Marina, Reynolds, Louise E., de Luxán-Delgado, Beatriz, Maiques, Oscar, Wisniewski, Laura, Newport, Emma, Rajeeve, Vinothini, Drake, Rebecca J.G., Gómez-Escudero, Jesús, Richards, Frances M., Weller, Céline, Dormann, Christof, Meng, Ya-Ming, Vermeulen, Peter B., Saur, Dieter, Sanz-Moreno, Victoria, Wong, Ping-Pui, Géraud, Cyrill, Cutillas, Pedro R., Hodivala-Dilke, Kairbaan
Publicado 2022