Consecutive non-natural PZ nucleobase pairs in DNA impact helical structure as seen in 50 μs molecular dynamics simulations

por Molt, Robert W., Georgiadis, Millie M., Richards, Nigel G.J.
Publicado 2017

A Mechanochemical Switch to Control Radical Intermediates

por Brunk, Elizabeth, Kellett, Whitney F., Richards, Nigel G. J., Rothlisberger, Ursula
Publicado 2014

Building better enzymes: Molecular basis of improved non‐natural nucleobase incorporation by an evolved DNA polymerase

por Ouaray, Zahra, Singh, Isha, Georgiadis, Millie M., Richards, Nigel G. J.
Publicado 2019

Improving the Treatment of Acute Lymphoblastic Leukemia

por Radadiya, Ashish, Zhu, Wen, Coricello, Adriana, Alcaro, Stefano, Richards, Nigel G. J.
Publicado 2020

Building better polymerases: Engineering the replication of expanded genetic alphabets

por Ouaray, Zahra, Benner, Steven A., Georgiadis, Millie M., Richards, Nigel G. J.
Publicado 2020

Reactivity and mechanism in chemical and synthetic biology

por Richards, Nigel G. J., Bearne, Stephen L., Goto, Yuki, Parker, Emily J.
Publicado 2023

Whole-Genome Sequence of Streptomyces kaniharaensis Shomura and Niida SF-557

por Zhu, Wen, Liu, Xuan, Hughes, Margaret, de Crécy-Lagard, Valérie, Richards, Nigel G. J.
Publicado 2020

(19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA‐Catalyzed GTP Hydrolysis

por Jin, Yi, Molt, Robert W., Waltho, Jonathan P., Richards, Nigel G. J., Blackburn, G. Michael
Publicado 2016

PMP–diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis

por Gao, Sisi, Liu, Huanting, de Crécy-Lagard, Valérie, Zhu, Wen, Richards, Nigel G. J., Naismith, James H.
Publicado 2019

Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase

por Li, Wenbo, Girt, Georgina C., Radadiya, Ashish, Stewart, James J. P., Richards, Nigel G. J., Naismith, James H.
Publicado 2023

Cryo-EM and Molecular Dynamics Simulations Reveal Hidden Conformational Dynamics Controlling Ammonia Transport in Human Asparagine Synthetase

por Coricello, Adriana, Zhu, Wen, Lupia, Antonio, Gratteri, Carmen, Vos, Matthijn, Chaptal, Vincent, Alcaro, Stefano, Takagi, Yuichiro, Richards, Nigel G. J.
Publicado 2023

Assigning the EPR Fine Structure Parameters of the Mn(II) Centers in Bacillus subtilis Oxalate Decarboxylase by Site-Directed Mutagenesis and DFT/MM Calculations

por Campomanes, Pablo, Kellett, Whitney F., Easthon, Lindsey M., Ozarowski, Andrew, Allen, Karen N., Angerhofer, Alexander, Rothlisberger, Ursula, Richards, Nigel G. J.
Publicado 2014

Uncovering the chemistry of C–C bond formation in C-nucleoside biosynthesis: crystal structure of a C-glycoside synthase/PRPP complex

por Gao, Sisi, Radadiya, Ashish, Li, Wenbo, Liu, Huanting, Zhu, Wen, de Crécy-Lagard, Valérie, Richards, Nigel G. J., Naismith, James H.
Publicado 2020

Novel Dihydropyrimidinone Derivatives as Potential P-Glycoprotein Modulators

por Bijani, Sabera, Shaikh, Faraz, Mirza, Sheefa, Weng In Siu, Shirley, Jain, Nayan, Rawal, Rakesh, Richards, Nigel G. J., Shah, Anamik, Radadiya, Ashish
Publicado 2022

Substrate Binding Mode and Molecular Basis of a Specificity Switch in Oxalate Decarboxylase

por Zhu, Wen, Easthon, Lindsey M., Reinhardt, Laurie A., Tu, Chingkuang, Cohen, Steven E., Silverman, David N., Allen, Karen N., Richards, Nigel G. J.
Publicado 2016

Assessing the Influence of Mutation on GTPase Transition States by Using X‐ray Crystallography, (19)F NMR, and DFT Approaches

por Jin, Yi, Molt, Robert W., Pellegrini, Erika, Cliff, Matthew J., Bowler, Matthew W., Richards, Nigel G. J., Blackburn, G. Michael, Waltho, Jonathan P.
Publicado 2017

Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate Decarboxylase

por Vladimirova, Anna, Patskovsky, Yury, Fedorov, Alexander A., Bonanno, Jeffrey B., Fedorov, Elena V., Toro, Rafael, Hillerich, Brandan, Seidel, Ronald D., Richards, Nigel G. J., Almo, Steven C., Raushel, Frank M.
Publicado 2015

High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity

por Zhu, Wen, Radadiya, Ashish, Bisson, Claudine, Wenzel, Sabine, Nordin, Brian E., Martínez-Márquez, Francisco, Imasaki, Tsuyoshi, Sedelnikova, Svetlana E., Coricello, Adriana, Baumann, Patrick, Berry, Alexandria H., Nomanbhoy, Tyzoon K., Kozarich, John W., Jin, Yi, Rice, David W., Takagi, Yuichiro, Richards, Nigel G. J.
Publicado 2019

Author Correction: High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity

por Zhu, Wen, Radadiya, Ashish, Bisson, Claudine, Wenzel, Sabine, Nordin, Brian E., Martínez-Márquez, Francisco, Imasaki, Tsuyoshi, Sedelnikova, Svetlana E., Coricello, Adriana, Baumann, Patrick, Berry, Alexandria H., Nomanbhoy, Tyzoon K., Kozarich, John W., Jin, Yi, Rice, David W., Takagi, Yuichiro, Richards, Nigel G. J.
Publicado 2019