p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

por Cole, Alicia M, Ridgway, Rachel A, Derkits, Sahra E, Parry, Lee, Barker, Nick, Clevers, Hans, Clarke, Alan R, Sansom, Owen J
Publicado 2010

c-Src drives intestinal regeneration and transformation

por Cordero, Julia B, Ridgway, Rachel A, Valeri, Nicola, Nixon, Colin, Frame, Margaret C, Muller, William J, Vidal, Marcos, Sansom, Owen J
Publicado 2014

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

por Cheung, Eric C., Athineos, Dimitris, Lee, Pearl, Ridgway, Rachel A., Lambie, Wendy, Nixon, Colin, Strathdee, Douglas, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.
Publicado 2013

The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the Apc(Min/+ )mouse small intestine

por Patek, Charles E, Arends, Mark J, Rose, Lorraine, Luo, Feijun, Walker, Marion, Devenney, Paul S, Berry, Rachel L, Lawrence, Nicola J, Ridgway, Rachel A, Sansom, Owen J, Hooper, Martin L
Publicado 2008

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

por Kanellos, Georgios, Zhou, Jing, Patel, Hitesh, Ridgway, Rachel A., Huels, David, Gurniak, Christine B., Sandilands, Emma, Carragher, Neil O., Sansom, Owen J., Witke, Walter, Brunton, Valerie G., Frame, Margaret C.
Publicado 2015

RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes

por Johansson, Joel, Naszai, Mate, Hodder, Michael C., Pickering, Karen A., Miller, Bryan W., Ridgway, Rachel A., Yu, Yachuan, Peschard, Pascal, Brachmann, Saskia, Campbell, Andrew D., Cordero, Julia B., Sansom, Owen J.
Publicado 2019

Rpl24(Bst) mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

por Knight, John RP, Vlahov, Nikola, Gay, David M, Ridgway, Rachel A, Faller, William James, Proud, Christopher, Mallucci, Giovanna R, von der Haar, Tobias, Smales, Christopher Mark, Willis, Anne E, Sansom, Owen J
Publicado 2021

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

por Gay, David M., Ridgway, Rachel A., Müller, Miryam, Hodder, Michael C., Hedley, Ann, Clark, William, Leach, Joshua D., Jackstadt, Rene, Nixon, Colin, Huels, David J., Campbell, Andrew D., Bird, Thomas G., Sansom, Owen J.
Publicado 2019

Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

por Gay, David M., Ridgway, Rachel A., Müller, Miryam, Hodder, Michael C., Hedley, Ann, Clark, William, Leach, Joshua D., Jackstadt, Rene, Nixon, Colin, Huels, David J., Campbell, Andrew D., Bird, Thomas G., Sansom, Owen J.
Publicado 2019

MYC Is a Major Determinant of Mitotic Cell Fate

por Topham, Caroline, Tighe, Anthony, Ly, Peter, Bennett, Ailsa, Sloss, Olivia, Nelson, Louisa, Ridgway, Rachel A., Huels, David, Littler, Samantha, Schandl, Claudia, Sun, Ying, Bechi, Beatrice, Procter, David J., Sansom, Owen J., Cleveland, Don W., Taylor, Stephen S.
Publicado 2015

Macrophage derived Wnt signalling opposes Notch signalling in a Numb mediated manner to specify HPC fate in chronic liver disease in human and mouse

por Boulter, Luke, Govaere, Olivier, Bird, Tom G, Radulescu, Sorina, Ramachandran, Prakash, Pellicoro, Antonella, Ridgway, Rachel A, Seo, Sang Soo, Spee, Bart, Van Rooijen, Nico, Sansom, Owen J., Iredale, John P, Lowell, Sally, Roskams, Tania, Forbes, Stuart J
Publicado 2012

Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop

por Walter, Romina J., Sonnentag, Steffen J., Munoz-Sagredo, Leonel, Merkel, Melanie, Richert, Ludovic, Bunert, Felix, Heneka, Yvonne M., Loustau, Thomas, Hodder, Michael, Ridgway, Rachel A., Sansom, Owen J., Mely, Yves, Rothbauer, Ulrich, Schmitt, Mark, Orian-Rousseau, Véronique
Publicado 2022

Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron

por Lindström, Nils O, Lawrence, Melanie L, Burn, Sally F, Johansson, Jeanette A, Bakker, Elvira RM, Ridgway, Rachel A, Chang, C-Hong, Karolak, Michele J, Oxburgh, Leif, Headon, Denis J, Sansom, Owen J, Smits, Ron, Davies, Jamie A, Hohenstein, Peter
Publicado 2015

LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest

por Morton, Jennifer P., Jamieson, Nigel B., Karim, Saadia A., Athineos, Dimitris, Ridgway, Rachel A., Nixon, Colin, McKay, Colin J., Carter, Ross, Brunton, Valerie G., Frame, Margaret C., Ashworth, Alan, Oien, Karin A., Evans, T.R. Jeffry, Sansom, Owen J.
Publicado 2010

Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

por Liko, Dritan, Mitchell, Louise, Campbell, Kirsteen J., Ridgway, Rachel A., Jones, Carolyn, Dudek, Kate, King, Ayala, Bryson, Sheila, Stevenson, David, Blyth, Karen, Strathdee, Douglas, Morton, Jennifer P., Bird, Thomas G., Knight, John R. P., Willis, Anne E., Sansom, Owen J.
Publicado 2019

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

por Myant, Kevin B., Cammareri, Patrizia, McGhee, Ewan J., Ridgway, Rachel A., Huels, David J., Cordero, Julia B., Schwitalla, Sarah, Kalna, Gabriela, Ogg, Erinn-Lee, Athineos, Dimitris, Timpson, Paul, Vidal, Marcos, Murray, Graeme I., Greten, Florian R., Anderson, Kurt I., Sansom, Owen J.
Publicado 2013

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

por Cammareri, Patrizia, Vincent, David F, Hodder, Michael C, Ridgway, Rachel A, Murgia, Claudio, Nobis, Max, Campbell, Andrew D, Varga, Julia, Huels, David J, Subramani, Chithra, Prescott, Katie L H, Nixon, Colin, Hedley, Ann, Barry, Simon T, Greten, Florian R, Inman, Gareth J, Sansom, Owen J
Publicado 2017

Hepatic progenitor cells of biliary origin with liver repopulation capacity

por Lu, Wei-Yu, Bird, Thomas G, Boulter, Luke, Tsuchiya, Atsunori, Cole, Alicia M, Hay, Trevor, Guest, Rachel V, Wojtacha, Davina, Man, Tak Yung, Mackinnon, Alison, Ridgway, Rachel A, Kendall, Timothy, Williams, Michael J, Jamieson, Thomas, Raven, Alex, Hay, David C, Iredale, John P, Clarke, Alan R, Sansom, Owen J, Forbes, Stuart J
Publicado 2015

MmCMS: mouse models’ consensus molecular subtypes of colorectal cancer

por Amirkhah, Raheleh, Gilroy, Kathryn, Malla, Sudhir B., Lannagan, Tamsin R. M., Byrne, Ryan M., Fisher, Natalie C., Corry, Shania M., Mohamed, Noha-Ehssan, Naderi-Meshkin, Hojjat, Mills, Megan L., Campbell, Andrew D., Ridgway, Rachel A., Ahmaderaghi, Baharak, Murray, Richard, Llergo, Antoni Berenguer, Sanz-Pamplona, Rebeca, Villanueva, Alberto, Batlle, Eduard, Salazar, Ramon, Lawler, Mark, Sansom, Owen J., Dunne, Philip D.
Publicado 2023

Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression

por Bailey, Peter, Ridgway, Rachel A., Cammareri, Patrizia, Treanor-Taylor, Mairi, Bailey, Ulla-Maja, Schoenherr, Christina, Bone, Max, Schreyer, Daniel, Purdie, Karin, Thomson, Jason, Rickaby, William, Jackstadt, Rene, Campbell, Andrew D., Dimonitsas, Emmanouil, Stratigos, Alexander J., Arron, Sarah T., Wang, Jun, Blyth, Karen, Proby, Charlotte M., Harwood, Catherine A., Sansom, Owen J., Leigh, Irene M., Inman, Gareth J.
Publicado 2023