Manipulation of the Complement System for Benefit in Sepsis

por Ward, Peter A., Guo, Ren-Feng, Riedemann, Niels C.
Publicado 2012

Early Intra-Articular Complement Activation in Ankle Fractures

por Schmal, Hagen, Salzmann, Gian M., Niemeyer, Philipp, Langenmair, Elia, Guo, Renfeng, Schneider, Conny, Habel, Maria, Riedemann, Niels
Publicado 2014

The late phase of sepsis is characterized by an increased microbiological burden and death rate

por Otto, Gordon P, Sossdorf, Maik, Claus, Ralf A, Rödel, Jürgen, Menge, Katja, Reinhart, Konrad, Bauer, Michael, Riedemann, Niels C
Publicado 2011

Evaluation of a Polymerase Chain Reaction Assay for Pathogen Detection in Septic Patients under Routine Condition: An Observational Study

por Bloos, Frank, Sachse, Svea, Kortgen, Andreas, Pletz, Mathias W., Lehmann, Marc, Straube, Eberhard, Riedemann, Niels C., Reinhart, Konrad, Bauer, Michael
Publicado 2012

Pharmacokinetic analysis of vilobelimab, anaphylatoxin C5a and antidrug antibodies in PANAMO: a phase 3 study in critically ill,  invasively mechanically ventilated COVID-19 patien...

por Lim, Endry H. T., Vlaar, Alexander P. J., de Bruin, Sanne, Rückinger, Simon, Thielert, Claus, Habel, Maria, Guo, Renfeng, Burnett, Bruce P., Dickinson, James, Brouwer, Matthijs C., Riedemann, Niels C., van de Beek, Diederik
Publicado 2023

87. The safety and efficacy advantage of blocking C5a vs C5 in critically ill, COVID-19 patients: Results from PANAMO, a Phase 3 randomized controlled trial

por Burnett, Bruce P, Lim, Endry H T, Vlaar, Alexander, De Bruin, Sanne, Brouwer, Matthijs, Habel, Maria, Thielert, Claus, Dickinson, James, Rückinger, simon, Zerbib, Robert, Neukirchen, Dorothee, Guo, Renfeng, van de Beek, Diederik, Riedemann, Niels
Publicado 2023

The anti‐C5a antibody vilobelimab efficiently inhibits C5a in patients with severe COVID‐19

por Vlaar, Alexander P. J., Lim, Endry H. T., de Bruin, Sanne, Rückinger, Simon, Pilz, Korinna, Brouwer, Matthijs C., Guo, Ren‐Feng, Heunks, Leo M. A., Busch, Matthias H., van Paassen, Pieter, Riedemann, Niels C., van de Beek, Diederik
Publicado 2022

Efficacy and Safety of Vilobelimab (IFX-1), a Novel Monoclonal Anti-C5a Antibody, in Patients With Early Severe Sepsis or Septic Shock—A Randomized, Placebo-Controlled, Double-Blin...

por Bauer, Michael, Weyland, Andreas, Marx, Gernot, Bloos, Frank, Weber, Stephan, Weiler, Norbert, Kluge, Stefan, Diers, Anja, Simon, Tim Philipp, Lautenschläger, Ingmar, Gründling, Matthias, Jaschinski, Ulrich, Simon, Philipp, Nierhaus, Axel, Moerer, Onnen, Reill, Lorenz, Jörres, Achim, Guo, Renfeng, Loeffler, Markus, Reinhart, Konrad, Riedemann, Niels
Publicado 2021

Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis

por Recknagel, Peter, Gonnert, Falk A., Westermann, Martin, Lambeck, Sandro, Lupp, Amelie, Rudiger, Alain, Dyson, Alex, Carré, Jane E., Kortgen, Andreas, Krafft, Christoph, Popp, Jürgen, Sponholz, Christoph, Fuhrmann, Valentin, Hilger, Ingrid, Claus, Ralf A., Riedemann, Niels C., Wetzker, Reinhard, Singer, Mervyn, Trauner, Michael, Bauer, Michael
Publicado 2012

Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-con...

por Vlaar, Alexander P J, Witzenrath, Martin, van Paassen, Pieter, Heunks, Leo M A, Mourvillier, Bruno, de Bruin, Sanne, Lim, Endry H T, Brouwer, Matthijs C, Tuinman, Pieter R, Saraiva, José F K, Marx, Gernot, Lobo, Suzana M, Boldo, Rodrigo, Simon-Campos, Jesus A, Cornet, Alexander D, Grebenyuk, Anastasia, Engelbrecht, Johannes M, Mukansi, Murimisi, Jorens, Philippe G, Zerbib, Robert, Rückinger, Simon, Pilz, Korinna, Guo, Renfeng, van de Beek, Diederik, Riedemann, Niels C
Publicado 2022

Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled tr...

por Vlaar, Alexander P J, de Bruin, Sanne, Busch, Matthias, Timmermans, Sjoerd A M E G, van Zeggeren, Ingeborg E, Koning, Rutger, ter Horst, Liora, Bulle, Esther B, van Baarle, Frank E H P, van de Poll, Marcel C G, Kemper, E Marleen, van der Horst, Iwan C C, Schultz, Marcus J, Horn, Janneke, Paulus, Frederique, Bos, Lieuwe D, Wiersinga, W Joost, Witzenrath, Martin, Rueckinger, Simon, Pilz, Korinna, Brouwer, Matthijs C, Guo, Ren-Feng, Heunks, Leo, van Paassen, Pieter, Riedemann, Niels C, van de Beek, Diederik
Publicado 2020