In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance

por Checkmahomed, Liva, Carbonneau, Julie, Du Pont, Venice, Riola, Nicholas C., Perry, Jason K., Li, Jiani, Paré, Bastien, Simpson, Shawn M., Smith, Martin A., Porter, Danielle P., Boivin, Guy
Publicado 2022

Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants

por Pitts, Jared, Li, Jiani, Perry, Jason K., Du Pont, Venice, Riola, Nicholas, Rodriguez, Lauren, Lu, Xianghan, Kurhade, Chaitanya, Xie, Xuping, Camus, Gregory, Manhas, Savrina, Martin, Ross, Shi, Pei-Yong, Cihlar, Tomas, Porter, Danielle P., Mo, Hongmei, Maiorova, Evguenia, Bilello, John P.
Publicado 2022

Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection

por Pitts, Jared, Babusis, Darius, Vermillion, Meghan S., Subramanian, Raju, Barrett, Kim, Lye, Diane, Ma, Bin, Zhao, Xiaofeng, Riola, Nicholas, Xie, Xuping, Kajon, Adriana, Lu, Xianghan, Bannister, Roy, Shi, Pei-Yong, Toteva, Maria, Porter, Danielle P., Smith, Bill J., Cihlar, Tomas, Mackman, Richard, Bilello, John P.
Publicado 2022

539. Efficacy in Multiple SARS-CoV-2 Animal Models Supports Phase 3 Dose Selection for Obeldesivir

por Pitts, Jared, Babusis, Darius, Humeniuk, Rita, Martinez, David, Cox, Robert M, Schäfer, Alexandra, Riola, Nicholas C, Feng, Joy, Du Pont, Venice, Anoshchenko, Olena, Vermillion, Meghan, Abdelghany, Mazin, Hyland, Robert H, Girish, Sandhya, Sheahan, Timothy P, Plemper, Richard K, Baric, Ralph S, Cihlar, Tomas, Llewellyn, Joe, Winter, Helen, Bannister, Roy, Subramanian, Raju, Mackman, Richard L, Bilello, John P
Publicado 2023