Bruton’s Tyrosine Kinase Inhibition as an Emerging Therapy in Systemic Autoimmune Disease

por Neys, Stefan F. H., Rip, Jasper, Hendriks, Rudi W., Corneth, Odilia B. J.
Publicado 2021

Toll-Like Receptor Signaling Drives Btk-Mediated Autoimmune Disease

por Rip, Jasper, de Bruijn, Marjolein J. W., Appelman, Marjolein K., Pal Singh, Simar, Hendriks, Rudi W., Corneth, Odilia B. J.
Publicado 2019

Aberrant B Cell Receptor Signaling in Naïve B Cells from Patients with Idiopathic Pulmonary Fibrosis

por Neys, Stefan F. H., Heukels, Peter, van Hulst, Jennifer A. C., Rip, Jasper, Wijsenbeek, Marlies S., Hendriks, Rudi W., Corneth, Odilia B. J.
Publicado 2021

Splenic Architecture and Function Requires Tight Control of Transmembrane TNF Expression

por Jeucken, Kim C. M., Kaaij, Merlijn H., Rip, Jasper, van Rooijen, Charlotte C. N., Kan, Yik Y., Corneth, Odilia B. J., van Hamburg, Jan Piet, Tas, Sander W.
Publicado 2022

Bruton's tyrosine kinase inhibition induces rewiring of proximal and distal B‐cell receptor signaling in mice

por Rip, Jasper, de Bruijn, Marjolein J. W., Neys, Stefan F. H., Singh, Simar Pal, Willar, Jonas, van Hulst, Jennifer A. C., Hendriks, Rudi W., Corneth, Odilia B. J.
Publicado 2021

Evidence for enhanced Bruton’s tyrosine kinase activity in transitional and naïve B cells of patients with granulomatosis with polyangiitis

por von Borstel, Anouk, Abdulahad, Wayel H, Sanders, Jan Stephan, Rip, Jasper, Neys, Stefan F H, Hendriks, Rudi W, Stegeman, Coen A, Heeringa, Peter, Rutgers, Abraham, Corneth, Odilia B J
Publicado 2019

Human T-bet(+) B cell development is associated with BTK activity and suppressed by evobrutinib

por Rijvers, Liza, van Langelaar, Jamie, Bogers, Laurens, Melief, Marie-José, Koetzier, Steven C., Blok, Katelijn M., Wierenga-Wolf, Annet F., de Vries, Helga E., Rip, Jasper, Corneth, Odilia B.J., Hendriks, Rudi W., Grenningloh, Roland, Boschert, Ursula, Smolders, Joost, van Luijn, Marvin M.
Publicado 2022

Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model

por Kumar, Sumit, Schoonderwoerd, Mark J A, Kroonen, Jessie S, de Graaf, Ilona J, Sluijter, Marjolein, Ruano, Dina, González-Prieto, Román, Verlaan-de Vries, Matty, Rip, Jasper, Arens, Ramon, de Miranda, Noel F C C, Hawinkels, Lukas J A C, van Hall, Thorbald, Vertegaal, Alfred C O
Publicado 2022

A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection

por Pardieck, Iris N., van der Sluis, Tetje C., van der Gracht, Esmé T. I., Veerkamp, Dominique M. B., Behr, Felix M., van Duikeren, Suzanne, Beyrend, Guillaume, Rip, Jasper, Nadafi, Reza, Beyranvand Nejad, Elham, Mülling, Nils, Brasem, Dena J., Camps, Marcel G. M., Myeni, Sebenzile K., Bredenbeek, Peter J., Kikkert, Marjolein, Kim, Yeonsu, Cicin-Sain, Luka, Abdelaal, Tamim, van Gisbergen, Klaas P. J. M., Franken, Kees L. M. C., Drijfhout, Jan Wouter, Melief, Cornelis J. M., Zondag, Gerben C. M., Ossendorp, Ferry, Arens, Ramon
Publicado 2022