Transcriptional profiling of the nucleus pulposus: say yes to notochord

por Shapiro, Irving M, Risbud, Makarand V
Publicado 2010

Alterations in ECM signature underscore multiple sub-phenotypes of intervertebral disc degeneration

por Ohnishi, Takashi, Novais, Emanuel J., Risbud, Makarand V.
Publicado 2020

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP

por Johnson, Zariel I., Shapiro, Irving M., Risbud, Makarand V.
Publicado 2014

Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration

por Gorth, Deborah J., Shapiro, Irving M., Risbud, Makarand V.
Publicado 2018

New horizons in spine research: Disc biology, tissue engineering, biomechanics, translational, and clinical research

por Dahia, Chitra L., Iatridis, James C., Risbud, Makarand V.
Publicado 2018

Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death

por Silagi, Elizabeth S., Batista, Philip, Shapiro, Irving M., Risbud, Makarand V.
Publicado 2018

Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation

por Choi, Hyowon, Madhu, Vedavathi, Shapiro, Irving M., Risbud, Makarand V.
Publicado 2019

Editorial: Intervertebral disc degeneration and osteoarthritis: mechanisms of disease and functional repair

por Teixeira, Graciosa Q., Riegger, Jana, Gonçalves, Raquel M., Risbud, Makarand V.
Publicado 2023

Corrigendum: The cGAS-STING pathway affects vertebral bone but does not promote intervertebral disc cell senescence or degeneration

por Ottone, Olivia K., Kim, C. James, Collins, John A., Risbud, Makarand V.
Publicado 2023

The cGAS-STING Pathway Affects Vertebral Bone but Does Not Promote Intervertebral Disc Cell Senescence or Degeneration

por Ottone, Olivia K., Kim, C. James, Collins, John A., Risbud, Makarand V.
Publicado 2022

BMP-2 and TGF-β Stimulate Expression of β1,3-Glucuronosyl Transferase 1 (GlcAT-1) in Nucleus Pulposus Cells Through AP1, TonEBP, and Sp1: Role of MAPKs

por Hiyama, Akihiko, Gogate, Shilpa S, Gajghate, Sachin, Mochida, Joji, Shapiro, Irving M, Risbud, Makarand V
Publicado 2010

Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus

por Liu, Chao, Choi, Hyowon, Johnson, Zariel I., Tian, Jiwei, Shapiro, Irving M., Risbud, Makarand V.
Publicado 2017

GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc

por Johnston, Shira N., Silagi, Elizabeth S., Madhu, Vedavathi, Nguyen, Duc H., Shapiro, Irving M., Risbud, Makarand V.
Publicado 2023

Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health

por Suyama, Kaori, Silagi, Elizabeth S., Choi, Hyowon, Sakabe, Kou, Mochida, Joji, Shapiro, Irving M., Risbud, Makarand V.
Publicado 2016

Abcc6 Null Mice—a Model for Mineralization Disorder PXE Shows Vertebral Osteopenia Without Enhanced Intervertebral Disc Calcification With Aging

por Boneski, Paige K., Madhu, Vedavathi, Tomlinson, Ryan E., Shapiro, Irving M., van de Wetering, Koen, Risbud, Makarand V.
Publicado 2022

Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc

por Ohnishi, Takashi, Tran, Victoria, Sao, Kimheak, Ramteke, Pranay, Querido, William, Barve, Ruteja A., van de Wetering, Koen, Risbud, Makarand V.
Publicado 2023

Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus

por Merceron, Christophe, Mangiavini, Laura, Robling, Alexander, Wilson, Tremika LeShan, Giaccia, Amato J., Shapiro, Irving M., Schipani, Ernestina, Risbud, Makarand V.
Publicado 2014

The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc

por Madhu, Vedavathi, Hernandez-Meadows, Miriam, Boneski, Paige K, Qiu, Yunping, Guntur, Anyonya R, Kurland, Irwin J., Barve, Ruteja A, Risbud, Makarand V.
Publicado 2023

Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment

por Fujii, Kengo, Yamazaki, Masashi, Kang, James D, Risbud, Makarand V, Cho, Samuel K, Qureshi, Sheeraz A, Hecht, Andrew C, Iatridis, James C
Publicado 2019

An organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes

por Markova, Dessislava Z, Kepler, Christopher K, Addya, Sankar, Murray, Hallie B, Vaccaro, Alexander R, Shapiro, Irving M, Greg Anderson, D, Albert, Todd J, Risbud, Makarand V
Publicado 2013