Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway

por Jeong, Woo-Jeong, Ro, Eun Ji, Choi, Kang-Yell
Publicado 2018

WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

por Ro, Eun Ji, Cho, Yong-Hee, Jeong, Woo-Jeong, Park, Jong-Chan, Min, Do Sik, Choi, Kang-Yell
Publicado 2019

Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells

por Cho, Yong-Hee, Ro, Eun Ji, Yoon, Jeong-Su, Kwak, Dong-Kyu, Cho, Jaebeom, Kang, Dong Woo, Lee, Ho-Young, Choi, Kang-Yell
Publicado 2020

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling

por Shin, Wookjin, Lee, Sang-Kyu, Hwang, Jeong-Ha, Park, Jong-Chan, Cho, Yong-Hee, Ro, Eun Ji, Song, Yeonhwa, Seo, Haeng Ran, Choi, Kang-Yell
Publicado 2018

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

por Cho, Yong-Hee, Ro, Eun Ji, Yoon, Jeong-Su, Mizutani, Tomohiro, Kang, Dong-Woo, Park, Jong-Chan, Il Kim, Tae, Clevers, Hans, Choi, Kang-Yell
Publicado 2020

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

por Jeong, Woo-Jeong, Park, Jong-Chan, Kim, Woo-Shin, Ro, Eun Ji, Jeon, Soung Hoo, Lee, Sang-Kyu, Park, Young Nyun, Min, Do Sik, Choi, Kang-Yell
Publicado 2019

Small molecule inhibitors of the Dishevelled‐CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy

por Kim, Hyun‐Yi, Choi, Sehee, Yoon, Ji‐Hye, Lim, Hwan Jung, Lee, Hyuk, Choi, Jiwon, Ro, Eun Ji, Heo, Jung‐Nyoung, Lee, Weontae, No, Kyoung Tai, Choi, Kang‐Yell
Publicado 2016

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

por Lee, Sang-Kyu, Cho, Yong-Hee, Cha, Pu-Hyeon, Yoon, Jeong-Soo, Ro, Eun Ji, Jeong, Woo-Jeong, Park, Jieun, Kim, Hyuntae, Il Kim, Tae, Min, Do Sik, Han, Gyoonhee, Choi, Kang-Yell
Publicado 2018

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer

por Cho, Yong-Hee, Cha, Pu-Hyeon, Kaduwal, Saluja, Park, Jong-Chan, Lee, Sang-Kyu, Yoon, Jeong-Soo, Shin, Wookjin, Kim, Hyuntae, Ro, Eun Ji, Koo, Kyung-Hwa, Park, Ki-Sook, Han, Gyoonhee, Choi, Kang-Yell
Publicado 2016