Genetic Alterations and Therapeutic Targeting of Philadelphia-Like Acute Lymphoblastic Leukemia

por Iacobucci, Ilaria, Roberts, Kathryn G.
Publicado 2021

The EBF1-PDGFRB T681I mutation is highly resistant to imatinib and dasatinib in vitro and detectable in clinical samples prior to treatment

por Tran, Thai Hoa, Nguyen, Jonathan V., Stecula, Adrian, Akutagawa, Jon, Moorman, Anthony V., Braun, Benjamin S., Sali, Andrej, Mullighan, Charles G., Shah, Neil P., Dai, Yunfeng, Devidas, Meenakshi, Roberts, Kathryn G., Smith, Catherine C., Loh, Mignon L.
Publicado 2021

Acute lymphoblastic leukemia displays a distinct highly methylated genome

por Hetzel, Sara, Mattei, Alexandra L., Kretzmer, Helene, Qu, Chunxu, Chen, Xiang, Fan, Yiping, Wu, Gang, Roberts, Kathryn G., Luger, Selina, Litzow, Mark, Rowe, Jacob, Paietta, Elisabeth, Stock, Wendy, Mardis, Elaine R., Wilson, Richard K., Downing, James R., Mullighan, Charles G., Meissner, Alexander
Publicado 2022

A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1

por Closa, Adria, Reixachs-Solé, Marina, Fuentes-Fayos, Antonio C, Hayer, Katharina E, Melero, Juan L, Adriaanse, Fabienne R S, Bos, Romy S, Torres-Diz, Manuel, Hunger, Stephen P, Roberts, Kathryn G, Mullighan, Charles G, Stam, Ronald W, Thomas-Tikhonenko, Andrei, Castaño, Justo P, Luque, Raúl M, Eyras, Eduardo
Publicado 2022

At three years, patients with acute lymphoblastic leukaemia are still at risk for relapse. Results of the international MRC UKALLXII/ECOG E2993 trial

por Ganzel, Chezi, Wang, Xin V., Rowe, Jacob M., Richards, Susan M., Buck, Georgina, Marks, David I., Litzow, Mark R., Paietta, Elisabeth M., Foroni, Letizia, Luger, Selina M., Willman, Cheryl L., Mullighan, Charles G., Roberts, Kathryn G., Wiernik, Peter H., Douer, Dan, Lazarus, Hillard M., Tallman, Martin S., Goldstone, Anthony H.
Publicado 2020

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome

por Witkowski, Matthew T., Hu, Yifang, Roberts, Kathryn G., Boer, Judith M., McKenzie, Mark D., Liu, Grace J., Le Grice, Oliver D., Tremblay, Cedric S., Ghisi, Margherita, Willson, Tracy A., Horstmann, Martin A., Aifantis, Iannis, Cimmino, Luisa, Frietze, Seth, den Boer, Monique L., Mullighan, Charles G., Smyth, Gordon K., Dickins, Ross A.
Publicado 2017

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia

por Ryan, Sarra L., Peden, John F., Kingsbury, Zoya, Schwab, Claire J., James, Terena, Polonen, Petri, Mijuskovic, Martina, Becq, Jenn, Yim, Richard, Cranston, Ruth E., Hedges, Dale J., Roberts, Kathryn G., Mullighan, Charles G., Vora, Ajay, Russell, Lisa J., Bain, Robert, Moorman, Anthony V., Bentley, David R., Harrison, Christine J., Ross, Mark T.
Publicado 2023

Pharmacotypes across the genomic landscape of pediatric acute lymphoblastic leukemia and impact on treatment response

por Lee, Shawn H. R., Yang, Wenjian, Gocho, Yoshihiro, John, August, Rowland, Lauren, Smart, Brandon, Williams, Hannah, Maxwell, Dylan, Hunt, Jeremy, Yang, Wentao, Crews, Kristine R., Roberts, Kathryn G., Jeha, Sima, Cheng, Cheng, Karol, Seth E., Relling, Mary V., Rosner, Gary L., Inaba, Hiroto, Mullighan, Charles G., Pui, Ching-Hon, Evans, William E., Yang, Jun J.
Publicado 2023

Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome–like acute B-cell lymphoblastic...

por Zhang, Qi, Shi, Ce, Han, Lina, Jain, Nitin, Roberts, Kathryn G., Ma, Helen, Cai, Tianyu, Cavazos, Antonio, Tabe, Yoko, Jacamo, Rodrigo O., Mu, Hong, Zhao, Yang, Wang, Jing, Wu, Shuo-Chieh, Cao, Fenglin, Zeng, Zhihong, Zhou, Jin, Mi, Yingchang, Jabbour, Elias J., Levine, Ross, Tasian, Sarah K., Mullighan, Charles G., Weinstock, David M., Fruman, David A., Konopleva, Marina
Publicado 2018

Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia with kinase fusions in Taiwan

por Hsu, Yin-Chen, Yu, Chih-Hsiang, Chen, Yan-Ming, Roberts, Kathryn G., Ni, Yu-Ling, Lin, Kai-Hsin, Jou, Shiann-Tarng, Lu, Meng-Yao, Chen, Shu-Huey, Wu, Kang-Hsi, Chang, Hsiu-Hao, Lin, Dong-Tsamn, Lin, Shu-Wha, Lin, Ze-Shiang, Chiu, Wei-Tzu, Chang, Chia-Ching, Ho, Bing-Ching, Mullighan, Charles G., Yu, Sung-Liang, Yang, Yung-Li
Publicado 2021

Amino acid stress response genes promote L-asparaginase resistance in pediatric acute lymphoblastic leukemia

por Ferguson, Daniel C., McCorkle, J. Robert, Barnett, Kelly R., Bonten, Erik J., Bergeron, Brennan P., Bhattarai, Kashi Raj, Yang, Wenjian, Smith, Colton, Hansen, Baranda S., Bajpai, Richa, Dong, Qian, Autry, Robert J., Gocho, Yoshihiro, Diedrich, Jonathan D., Crews, Kristine R., Pruett-Miller, Shondra M., Roberts, Kathryn G., Stock, Wendy, Mullighan, Charles G., Inaba, Hiroto, Jeha, Sima, Pui, Ching-Hon, Yang, Jun J., Relling, Mary V., Evans, William E., Savic, Daniel
Publicado 2022

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

por Almeida, Afonso R. M., Neto, João L., Cachucho, Ana, Euzébio, Mayara, Meng, Xiangyu, Kim, Rathana, Fernandes, Marta B., Raposo, Beatriz, Oliveira, Mariana L., Ribeiro, Daniel, Fragoso, Rita, Zenatti, Priscila P., Soares, Tiago, de Matos, Mafalda R., Corrêa, Juliana Ronchi, Duque, Mafalda, Roberts, Kathryn G., Gu, Zhaohui, Qu, Chunxu, Pereira, Clara, Pyne, Susan, Pyne, Nigel J., Barreto, Vasco M., Bernard-Pierrot, Isabelle, Clappier, Emannuelle, Mullighan, Charles G., Grosso, Ana R., Yunes, J. Andrés, Barata, João T.
Publicado 2021

MLL Rearrangements Impact Outcome in HOXA-deregulated T-lineage Acute Lymphoblastic Leukemia: A Children's Oncology Group Study

por Matlawska-Wasowska, Ksenia, Kang, Huining, Devidas, Meenakshi, Wen, Ji, Harvey, Richard C., Nickl, Christian K., Ness, Scott A., Rusch, Michael, Li, Yongjin, Onozawa, Masahiro, Martinez, Carmen, Wood, Brent L., Asselin, Barbara L., Chen, I-Ming, Roberts, Kathryn G., Baruchel, André, Soulier, Jean, Dombret, Hervé, Zhang, Jinghui, Larson, Richard S., Raetz, Elizabeth A., Carroll, William L., Winick, Naomi J., Aplan, Peter D., Loh, Mignon L., Mullighan, Charles G., Hunger, Stephen P., Heerema, Nyla A., Carroll, Andrew J., Dunsmore, Kimberly P., Winter, Stuart S.
Publicado 2016