Structure and Dynamics of the EGF Receptor as Revealed by Experiments and Simulations and Its Relevance to Non-Small Cell Lung Cancer

por Martin-Fernandez, Marisa L., Clarke, David T., Roberts, Selene K., Zanetti-Domingues, Laura C., Gervasio, Francesco L.
Publicado 2019

The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity

por Elbediwy, Ahmed, Zhang, Yixiao, Cobbaut, Mathias, Riou, Philippe, Tan, Ray S., Roberts, Selene K., Tynan, Chris, George, Roger, Kjaer, Svend, Martin-Fernandez, Marisa L., Thompson, Barry J., McDonald, Neil Q., Parker, Peter J.
Publicado 2019

A small molecule inhibitor of HER3: a proof-of-concept study

por Colomba, Audrey, Fitzek, Martina, George, Roger, Weitsman, Gregory, Roberts, Selene, Zanetti-Domingues, Laura, Hirsch, Michael, Rolfe, Daniel J., Mehmood, Shahid, Madin, Andrew, Claus, Jeroen, Kjaer, Svend, Snijders, Ambrosius P., Ng, Tony, Martin-Fernandez, Marisa, Smith, David M., Parker, Peter J.
Publicado 2020

Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface

por Claus, Jeroen, Patel, Gargi, Autore, Flavia, Colomba, Audrey, Weitsman, Gregory, Soliman, Tanya N, Roberts, Selene, Zanetti-Domingues, Laura C, Hirsch, Michael, Collu, Francesca, George, Roger, Ortiz-Zapater, Elena, Barber, Paul R, Vojnovic, Boris, Yarden, Yosef, Martin-Fernandez, Marisa L, Cameron, Angus, Fraternali, Franca, Ng, Tony, Parker, Peter J
Publicado 2018

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

por Needham, Sarah R., Roberts, Selene K., Arkhipov, Anton, Mysore, Venkatesh P., Tynan, Christopher J., Zanetti-Domingues, Laura C., Kim, Eric T., Losasso, Valeria, Korovesis, Dimitrios, Hirsch, Michael, Rolfe, Daniel J., Clarke, David T., Winn, Martyn D., Lajevardipour, Alireza, Clayton, Andrew H. A., Pike, Linda J., Perani, Michela, Parker, Peter J., Shan, Yibing, Shaw, David E., Martin-Fernandez, Marisa L.
Publicado 2016

The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers

por Zanetti-Domingues, Laura C., Korovesis, Dimitrios, Needham, Sarah R., Tynan, Christopher J., Sagawa, Shiori, Roberts, Selene K., Kuzmanic, Antonija, Ortiz-Zapater, Elena, Jain, Purvi, Roovers, Rob C., Lajevardipour, Alireza, van Bergen en Henegouwen, Paul M. P., Santis, George, Clayton, Andrew H. A., Clarke, David T., Gervasio, Francesco L., Shan, Yibing, Shaw, David E., Rolfe, Daniel J., Parker, Peter J., Martin-Fernandez, Marisa L.
Publicado 2018