Acting like Actin: The Dynamics of the Nematode Major Sperm Protein (Msp) Cytoskeleton Indicate a Push-Pull Mechanism for Amoeboid Cell Motility

por Roberts, Thomas M., Stewart, Murray
Publicado 2000

The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities

por Chang, Hyeyoun, Cai, Zhenying, Roberts, Thomas M.
Publicado 2019

Hydrostatic Pressure Shows That Lamellipodial Motility in Ascaris Sperm Requires Membrane-associated Major Sperm Protein Filament Nucleation and Elongation

por Roberts, Thomas M., Salmon, E.D., Stewart, Murray
Publicado 1998

Localized Depolymerization of the Major Sperm Protein Cytoskeleton Correlates with the Forward Movement of the Cell Body in the Amoeboid Movement of Nematode Sperm

por Italiano, Joseph E., Stewart, Murray, Roberts, Thomas M.
Publicado 1999

Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss

por Cizmecioglu, Onur, Ni, Jing, Xie, Shaozhen, Zhao, Jean J, Roberts, Thomas M
Publicado 2016

A Conditional Dependency on MELK for the Proliferation of Triple-Negative Breast Cancer Cells

por Wang, Yubao, Li, Ben B., Li, Jing, Roberts, Thomas M., Zhao, Jean J.
Publicado 2018

The role of the PIK3CA gene in the development and aging of the brain

por Xie, Shaozhen, Ni, Jing, Guo, Hanbing, Luu, Victor, Wang, Yanzhi, Zhao, Jean J., Roberts, Thomas M.
Publicado 2021

RNAi-Based Approaches for Pancreatic Cancer Therapy

por Kim, Min Ju, Chang, Hyeyoun, Nam, Gihoon, Ko, Youngji, Kim, Sun Hwa, Roberts, Thomas M., Ryu, Ju Hee
Publicado 2021

NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K–AKT and JAK–STAT3 pathways

por Yuzugullu, Haluk, Von, Thanh, Thorpe, Lauren M, Walker, Sarah R, Roberts, Thomas M, Frank, David A, Zhao, Jean J
Publicado 2016

Polyoma small T antigen triggers cell death via mitotic catastrophe

por Fernando, Arun T Pores, Andrabi, Shaida, Cizmecioglu, Onur, Zhu, Cailei, Livingston, David M., Higgins, Jonathan M.G, Schaffhausen, Brian S, Roberts, Thomas M
Publicado 2014

Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer

por Wang, Dong, Wang, Min, Jiang, Nan, Zhang, Yuan, Bian, Xing, Wang, Xiaoqing, Roberts, Thomas M., Zhao, Jean J., Liu, Pixu, Cheng, Hailing
Publicado 2016

PCTAIRE1 promotes mitotic progression and resistance against antimitotic and apoptotic signals

por Gillani, Syed Qaaifah, Reshi, Irfana, Nabi, Nusrat, Un Nisa, Misbah, Sarwar, Zarka, Bhat, Sameer, Roberts, Thomas M., Higgins, Jonathan M. G., Andrabi, Shaida
Publicado 2022

The Identification of Zebrafish Mutants Showing Alterations in Senescence-Associated Biomarkers

por Kishi, Shuji, Bayliss, Peter E., Uchiyama, Junzo, Koshimizu, Eriko, Qi, Jie, Nanjappa, Purushothama, Imamura, Shintaro, Islam, Asiful, Neuberg, Donna, Amsterdam, Adam, Roberts, Thomas M.
Publicado 2008

A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis

por Yuzugullu, Haluk, Baitsch, Lukas, Von, Thanh, Steiner, Allison, Tong, Haoxuan, Ni, Jing, Clayton, Linda K., Bronson, Roderick, Roberts, Thomas M., Gritsman, Kira, Zhao, Jean J.
Publicado 2015

Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

por Xie, Shaozhen, Ni, Jing, McFaline-Figueroa, J. Ricardo, Wang, Yanzhi, Bronson, Roderick T., Ligon, Keith L., Wen, Patrick Y., Roberts, Thomas M., Zhao, Jean J.
Publicado 2020

Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers

por Sun, Bowen, Mason, Seth, Wilson, Robert C., Hazard, Starr E., Wang, Yubao, Fang, Rong, Wang, Qiwei, Yeh, Elizabeth S., Yang, Meixiang, Roberts, Thomas M., Zhao, Jean J., Wang, Qi
Publicado 2019

K-RAS Mutant Pancreatic Tumors Show Higher Sensitivity to MEK than to PI3K Inhibition In Vivo

por Hofmann, Irmgard, Weiss, Andreas, Elain, Gaelle, Schwaederle, Maria, Sterker, Dario, Romanet, Vincent, Schmelzle, Tobias, Lai, Albert, Brachmann, Saskia M., Bentires-Alj, Mohamed, Roberts, Thomas M., Sellers, William R., Hofmann, Francesco, Maira, Sauveur-Michel
Publicado 2012

PIK3CA(H1047R) and Her2 initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling

por Cheng, Hailing, Liu, Pixu, Ohlson, Carolynn, Xu, Erbo, Symonds, Lynn, Isabella, Adam, Muller, William J., Lin, Nancy U., Krop, Ian E., Roberts, Thomas M., Winer, Eric P., Arteaga, Carlos L., Zhao, Jean J.
Publicado 2015

A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis

por Imamura, Shintaro, Uchiyama, Junzo, Koshimizu, Eriko, Hanai, Jun-ichi, Raftopoulou, Christina, Murphey, Ryan D., Bayliss, Peter E., Imai, Yoichi, Burns, Caroline Erter, Masutomi, Kenkichi, Gagos, Sarantis, Zon, Leonard I., Roberts, Thomas M., Kishi, Shuji
Publicado 2008

The XLMR gene PHF8 encodes a histone H4K20/H3K9 demethylase and regulates zebrafish brain and craniofacial development

por Qi, Hank H., Sarkissian, Madathia, Hu, Gang-Qing, Wang, Zhibin, Bhattacharjee, Arindam, Gordon, D. Benjamin, Gonzales, Michelle, Lan, Fei, Ongusaha, Pat P., Huarte, Maite, Yaghi, Nasser K., Lim, Huijun, Garcia, Benjamin A., Brizuela, Leonardo, Zhao, Keji, Roberts, Thomas M., Shi, Yang
Publicado 2010