Shining a light on autophagy in neurodegenerative diseases

por Chandran, Aswathy, Rochet, Jean-Christophe
Publicado 2021

Role of NFE2L1 in the Regulation of Proteostasis: Implications for Aging and Neurodegenerative Diseases

por Chandran, Aswathy, Oliver, Haley Jane, Rochet, Jean-Christophe
Publicado 2023

A novel pathway for amyloids self-assembly in aggregates at nanomolar concentration mediated by the interaction with surfaces

por Banerjee, Siddhartha, Hashemi, Mohtadin, Lv, Zhengjian, Maity, Sibaprasad, Rochet, Jean-Christophe, Lyubchenko, Yuri L.
Publicado 2017

Effect of Spermidine on Misfolding and Interactions of Alpha-Synuclein

por Krasnoslobodtsev, Alexey V., Peng, Jie, Asiago, Josephat M., Hindupur, Jagadish, Rochet, Jean-Christophe, Lyubchenko, Yuri L.
Publicado 2012

Identification of Novel Kinases of Tau Using Fluorescence Complementation Mass Spectrometry (FCMS)

por Kao, Der-Shyang, Du, Yanyan, DeMarco, Andrew G., Min, Sehong, Hall, Mark C., Rochet, Jean-Christophe, Tao, W. Andy
Publicado 2022

Developmental Pb exposure increases AD risk via altered intracellular Ca(2+) homeostasis in hiPSC-derived cortical neurons

por Xie, Junkai, Wu, Shichen, Szadowski, Hailey, Min, Sehong, Yang, Yang, Bowman, Aaron B., Rochet, Jean-Christophe, Freeman, Jennifer L., Yuan, Chongli
Publicado 2023

Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity

por Ysselstein, Daniel, Dehay, Benjamin, Costantino, Isabel M., McCabe, George P., Frosch, Matthew P., George, Julia M., Bezard, Erwan, Rochet, Jean-Christophe
Publicado 2017

5-Nitro-1,2-benzothiazol-3-amine and N-Ethyl-1-[(ethylcarbamoyl)(5-nitro-1,2-benzothiazol-3-yl)amino]formamide Modulate α-Synuclein and Tau Aggregation

por Ramirez, Eduardo, Ganegamage, Susantha K., Elbatrawy, Ahmed A., Alnakhala, Heba, Shimanaka, Kazuma, Tripathi, Arati, Min, Sehong, Rochet, Jean-Christophe, Dettmer, Ulf, Fortin, Jessica S.
Publicado 2023

TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo

por Lee-Gosselin, Audrey, Jury-Garfe, Nur, You, Yanwen, Dabin, Luke, Soni, Disha, Dutta, Sayan, Rochet, Jean-Christophe, Kim, Jungsu, Oblak, Adrian L., Lasagna-Reeves, Cristian A.
Publicado 2023

Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson’s disease

por Tambe, Mitali A., de Rus Jacquet, Aurelie, Strathearn, Katherine E., Yousef, Gad G., Grace, Mary H., Ferruzzi, Mario G., Wu, Qingli, Simon, James E., Lila, Mary Ann, Rochet, Jean-Christophe
Publicado 2023

Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time

por Prakash, Priya, Jethava, Krupal P., Korte, Nils, Izquierdo, Pablo, Favuzzi, Emilia, Rose, Indigo V. L., Guttenplan, Kevin A., Manchanda, Palak, Dutta, Sayan, Rochet, Jean-Christophe, Fishell, Gord, Liddelow, Shane A., Attwell, David, Chopra, Gaurav
Publicado 2021

Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

por Landeck, Natalie, Strathearn, Katherine E., Ysselstein, Daniel, Buck, Kerstin, Dutta, Sayan, Banerjee, Siddhartha, Lv, Zhengjian, Hulleman, John D., Hindupur, Jagadish, Lin, Li-Kai, Padalkar, Sonal, Stanciu, Lia A., Lyubchenko, Yuri L., Kirik, Deniz, Rochet, Jean-Christophe
Publicado 2020

Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson’s Disease

por Tambe, Mitali A., de Rus Jacquet, Aurélie, Strathearn, Katherine E., Hensel, Jennifer A., Colón, Bryce D., Chandran, Aswathy, Yousef, Gad G., Grace, Mary H., Ferruzzi, Mario G., Wu, Qingli, Simon, James E., Lila, Mary Ann, Rochet, Jean-Christophe
Publicado 2023

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation

por Que, Zhefu, Olivero-Acosta, Maria I., Chen, Ian, Zhang, Jingliang, Wettschurack, Kyle, Wu, Jiaxiang, Xiao, Tiange, Otterbacher, C. Max, Wang, Muhan, Harlow, Hope, Cui, Ningren, Chen, Xiaoling, Deming, Brody, Halurkar, Manasi, Zhao, Yuanrui, Rochet, Jean-Christophe, Xu, Ranjie, Brewster, Amy L., Wu, Long-jun, Yuan, Chongli, Skarnes, William C., Yang, Yang
Publicado 2023

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

por Tóth, Gergely, Gardai, Shyra J., Zago, Wagner, Bertoncini, Carlos W., Cremades, Nunilo, Roy, Susan L., Tambe, Mitali A., Rochet, Jean-Christophe, Galvagnion, Celine, Skibinski, Gaia, Finkbeiner, Steven, Bova, Michael, Regnstrom, Karin, Chiou, San-San, Johnston, Jennifer, Callaway, Kari, Anderson, John P., Jobling, Michael F., Buell, Alexander K., Yednock, Ted A., Knowles, Tuomas P. J., Vendruscolo, Michele, Christodoulou, John, Dobson, Christopher M., Schenk, Dale, McConlogue, Lisa
Publicado 2014

Bassoon contributes to tau-seed propagation and neurotoxicity

por Martinez, Pablo, Patel, Henika, You, Yanwen, Jury, Nur, Perkins, Abigail, Lee-Gosselin, Audrey, Taylor, Xavier, You, Yingjian, Viana Di Prisco, Gonzalo, Huang, Xiaoqing, Dutta, Sayan, Wijeratne, Aruna B., Redding-Ochoa, Javier, Shahid, Syed Salman, Codocedo, Juan F., Min, Sehong, Landreth, Gary E., Mosley, Amber L., Wu, Yu-Chien, McKinzie, David L., Rochet, Jean-Christophe, Zhang, Jie, Atwood, Brady K., Troncoso, Juan, Lasagna-Reeves, Cristian A.
Publicado 2022

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

por Tóth, Gergely, Neumann, Thomas, Berthet, Amandine, Masliah, Eliezer, Spencer, Brian, Tao, Jiahui, Jobling, Michael F., Gardai, Shyra J., Bertoncini, Carlos W., Cremades, Nunilo, Bova, Michael, Ballaron, Stephen, Chen, Xiao-Hua, Mao, Wenxian, Nguyen, Phuong, Tabios, Mariano C., Tambe, Mitali A., Rochet, Jean-Christophe, Junker, Hans-Dieter, Schwizer, Daniel, Sekul, Renate, Ott, Inge, Anderson, John P., Szoke, Balazs, Hoffman, Wherly, Christodoulou, John, Yednock, Ted, Agard, David A., Schenk, Dale, McConlogue, Lisa
Publicado 2019