Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak

por Rodrigues, João V, Shakhnovich, Eugene I
Publicado 2019

Development of antibacterial compounds that constrain evolutionary pathways to resistance

por Zhang, Yanmin, Chowdhury, Sourav, Rodrigues, João V, Shakhnovich, Eugene
Publicado 2021

Proteostasis Environment Shapes Higher-Order Epistasis Operating on Antibiotic Resistance

por Guerrero, Rafael F., Scarpino, Samuel V., Rodrigues, João V., Hartl, Daniel L., Ogbunugafor, C. Brandon
Publicado 2019

Empowering drug off-target discovery with metabolic and structural analysis

por Chowdhury, Sourav, Zielinski, Daniel C., Dalldorf, Christopher, Rodrigues, Joao V., Palsson, Bernhard O., Shakhnovich, Eugene I.
Publicado 2023

Ethylmalonic Encephalopathy ETHE1 R163W/R163Q Mutations Alter Protein Stability and Redox Properties of the Iron Centre

por Henriques, Bárbara J., Lucas, Tânia G., Rodrigues, João V., Frederiksen, Jane H., Teixeira, Miguel S., Tiranti, Valeria, Bross, Peter, Gomes, Cláudio M.
Publicado 2014

Resistance to dual-gene Bt maize in Spodoptera frugiperda: selection, inheritance, and cross-resistance to other transgenic events

por Santos-Amaya, Oscar F., Rodrigues, João V. C., Souza, Thadeu C., Tavares, Clébson S., Campos, Silverio O., Guedes, Raul N.C., Pereira, Eliseu J.G.
Publicado 2015

Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics

por Klein, Eili Y., Blumenkrantz, Deena, Serohijos, Adrian, Shakhnovich, Eugene, Choi, Jeong-Mo, Rodrigues, João V., Smith, Brendan D., Lane, Andrew P., Feldman, Andrew, Pekosz, Andrew
Publicado 2018

Illuminating protein space with a programmable generative model

por Ingraham, John B., Baranov, Max, Costello, Zak, Barber, Karl W., Wang, Wujie, Ismail, Ahmed, Frappier, Vincent, Lord, Dana M., Ng-Thow-Hing, Christopher, Van Vlack, Erik R., Tie, Shan, Xue, Vincent, Cowles, Sarah C., Leung, Alan, Rodrigues, João V., Morales-Perez, Claudio L., Ayoub, Alex M., Green, Robin, Puentes, Katherine, Oplinger, Frank, Panwar, Nishant V., Obermeyer, Fritz, Root, Adam R., Beam, Andrew L., Poelwijk, Frank J., Grigoryan, Gevorg
Publicado 2023

Evolution on the Biophysical Fitness Landscape of an RNA Virus

por Rotem, Assaf, Serohijos, Adrian W R, Chang, Connie B, Wolfe, Joshua T, Fischer, Audrey E, Mehoke, Thomas S, Zhang, Huidan, Tao, Ye, Lloyd Ung, W, Choi, Jeong-Mo, Rodrigues, João V, Kolawole, Abimbola O, Koehler, Stephan A, Wu, Susan, Thielen, Peter M, Cui, Naiwen, Demirev, Plamen A, Giacobbi, Nicholas S, Julian, Timothy R, Schwab, Kellogg, Lin, Jeffrey S, Smith, Thomas J, Pipas, James M, Wobus, Christiane E, Feldman, Andrew B, Weitz, David A, Shakhnovich, Eugene I
Publicado 2018