Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

por Rofo, Fadi, Metzendorf, Nicole G., Saubi, Cristina, Suominen, Laura, Godec, Ana, Sehlin, Dag, Syvänen, Stina, Hultqvist, Greta
Publicado 2022

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer’s Disease Mice

por Rofo, Fadi, Meier, Silvio R., Metzendorf, Nicole G., Morrison, Jamie I., Petrovic, Alex, Syvänen, Stina, Sehlin, Dag, Hultqvist, Greta
Publicado 2022

Standardized Preclinical In Vitro Blood–Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways

por Morrison, Jamie I., Petrovic, Alex, Metzendorf, Nicole G., Rofo, Fadi, Yilmaz, Canan U., Stenler, Sofia, Laudon, Hanna, Hultqvist, Greta
Publicado 2023

Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates

por Petersen, Inga, Ali, Muhammad Ilyas, Petrovic, Alex, Ytterberg, Anders Jimmy, Staxäng, Karin, Hodik, Monika, Rofo, Fadi, Bondza, Sina, Hultqvist, Greta
Publicado 2023

Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain

por Rofo, Fadi, Ugur Yilmaz, Canan, Metzendorf, Nicole, Gustavsson, Tobias, Beretta, Chiara, Erlandsson, Anna, Sehlin, Dag, Syvänen, Stina, Nilsson, Per, Hultqvist, Greta
Publicado 2021

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer’s Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

por Rofo, Fadi, Sandbaumhüter, Friederike A., Chourlia, Aikaterini, Metzendorf, Nicole G., Morrison, Jamie I., Syvänen, Stina, Andrén, Per E., Jansson, Erik T., Hultqvist, Greta
Publicado 2021

Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood–brain barrier shuttle scFv8D3

por de la Rosa, Andrés, Metzendorf, Nicole G., Morrison, Jamie I., Faresjö, Rebecca, Rofo, Fadi, Petrovic, Alex, O’Callaghan, Paul, Syvänen, Stina, Hultqvist, Greta
Publicado 2022

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

por Rofo, Fadi, Buijs, Jos, Falk, Ronny, Honek, Ken, Lannfelt, Lars, Lilja, Anna M., Metzendorf, Nicole G., Gustavsson, Tobias, Sehlin, Dag, Söderberg, Linda, Hultqvist, Greta
Publicado 2021