Development of New Meridianin/Leucettine-Derived Hybrid Small Molecules as Nanomolar Multi-Kinase Inhibitors with Antitumor Activity

por Elsherbeny, Mohamed H., Elkamhawy, Ahmed, Nada, Hossam, Abdellattif, Magda H., Lee, Kyeong, Roh, Eun Joo
Publicado 2021

Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds

por Farag, Ahmed K., Hassan, Ahmed H. E., Ahn, Byung Sun, Park, Ki Duk, Roh, Eun Joo
Publicado 2019

Development of selective blockers for Ca(2+)-activated Cl(- )channel using Xenopus laevis oocytes with an improved drug screening strategy

por Oh, Soo-Jin, Park, Jung Hwan, Han, Sungyu, Lee, Jae Kyun, Roh, Eun Joo, Lee, C Justin
Publicado 2008

Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening

por Elkamhawy, Ahmed, Ammar, Usama M., Paik, Sora, Abdellattif, Magda H., Elsherbeny, Mohamed H., Lee, Kyeong, Roh, Eun Joo
Publicado 2021

Design, Synthesis and Biological Evaluation of 1,3,5-Triazine Derivatives Targeting hA(1) and hA(3) Adenosine Receptor

por Park, Sujin, Ahn, Yujin, Kim, Yongchan, Roh, Eun Joo, Lee, Yoonji, Han, Chaebin, Yoo, Hee Min, Yu, Jinha
Publicado 2022

Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In...

por Elkamhawy, Ahmed, Paik, Sora, Ali, Eslam M. H., Hassan, Ahmed H. E., Kang, So Jin, Lee, Kyeong, Roh, Eun Joo
Publicado 2022

Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress

por Elkamhawy, Ahmed, Woo, Jiyu, Gouda, Noha A., Kim, Jushin, Nada, Hossam, Roh, Eun Joo, Park, Ki Duk, Cho, Jungsook, Lee, Kyeong
Publicado 2021

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors

por Al-Sanea, Mohammad M., Elkamhawy, Ahmed, Paik, Sora, Bua, Silvia, Ha Lee, So, Abdelgawad, Mohamed A., Roh, Eun Joo, Eldehna, Wagdy M., Supuran, Claudiu T.
Publicado 2019

Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B

por Elkamhawy, Ahmed, Paik, Sora, Kim, Hyeon Jeong, Park, Jong-Hyun, Londhe, Ashwini M., Lee, Kyeong, Pae, Ae Nim, Park, Ki Duk, Roh, Eun Joo
Publicado 2020

Highly Potent, Selective, and Competitive Indole-Based MAO-B Inhibitors Protect PC12 Cells against 6-Hydroxydopamine- and Rotenone-Induced Oxidative Stress

por Elsherbeny, Mohamed H., Kim, Jushin, Gouda, Noha A., Gotina, Lizaveta, Cho, Jungsook, Pae, Ae Nim, Lee, Kyeong, Park, Ki Duk, Elkamhawy, Ahmed, Roh, Eun Joo
Publicado 2021

AKF-D52, a Synthetic Phenoxypyrimidine-Urea Derivative, Triggers Extrinsic/Intrinsic Apoptosis and Cytoprotective Autophagy in Human Non-Small Cell Lung Cancer Cells

por Gil, Hyo-Sun, Lee, Jeong-Hun, Farag, Ahmed K., Hassan, Ahmed H. E., Chung, Kyung-Sook, Choi, Jung-Hye, Roh, Eun-Joo, Lee, Kyung-Tae
Publicado 2021

2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silic...

por Elsherbeny, Mohamed H., Ammar, Usama M., Abdellattif, Magda H., Abourehab, Mohammed A. S., Abdeen, Ahmed, Ibrahim, Samah F., Abdelrahaman, Doaa, Mady, Wessam, Roh, Eun Joo, Elkamhawy, Ahmed
Publicado 2022

Novel Rhodanine Derivative, 5-[4-(4-Fluorophenoxy) phenyl]methylene-3-{4-[3-(4-methylpiperazin-1-yl) propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride, Induces Apoptosis vi...

por Jung, Hye-Uk, Lee, Jeong-Hun, Chung, Kyung-Sook, Hong, Joo Young, Choi, Jung-Hye, Kim, Soo-Dong, Roh, Eun Joo, Shin, Kye Jung, Lee, Kyung-Tae
Publicado 2018

Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apopto...

por Mourad, Mai A. E., Abo Elmaaty, Ayman, Zaki, Islam, Mourad, Ahmed A. E., Hofni, Amal, Khodir, Ahmed E., Aboubakr, Esam M., Elkamhawy, Ahmed, Roh, Eun Joo, Al-Karmalawy, Ahmed A.
Publicado 2023

Design, Synthesis, In Vitro, and In Silico Studies of New N(5)-Substituted-pyrazolo[3,4-d]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors

por Zaki, Waheed A., El-Sayed, Selwan M., Alswah, Mohamed, El-Morsy, Ahmed, Bayoumi, Ashraf H., Mayhoub, Abrahman S., Moustafa, Walaa H., Awaji, Aeshah A., Roh, Eun Joo, Hassan, Ahmed H.E., Mahmoud, Kazem
Publicado 2023

Trifluoperazine and Its Analog Suppressed the Tumorigenicity of Non-Small Cell Lung Cancer Cell; Applicability of Antipsychotic Drugs to Lung Cancer Treatment

por Jeong, Joo Yeon, Park, Haangik, Yoo, Hong, Kim, Eun-Jin, Jeon, Borami, Lee, Jong Deog, Kang, Dawon, Lee, Changjoon Justin, Paek, Sun Ha, Roh, Eun Joo, Yi, Gwan-Su, Kang, Sang Soo
Publicado 2022

AF8c, a Multi-Kinase Inhibitor Induces Apoptosis by Activating DR5/Nrf2 via ROS in Colorectal Cancer Cells

por Jeong, Soyeon, Farag, Ahmed K., Yun, Hye Kyeong, Jeong, Yoon A., Kim, Dae Yeong, Jo, Min Jee, Park, Seong Hye, Kim, Bo Ram, Kim, Jung Lim, Kim, Bu Gyeom, Lee, Dae-Hee, Roh, Eun Joo, Oh, Sang Cheul
Publicado 2022