CRISPR-Cas9-Based Gene Knockout of Immune Checkpoints in Expanded NK Cells

por Mohammadian Gol, Tahereh, Kim, Miso, Sinn, Ralph, Ureña-Bailén, Guillermo, Stegmeyer, Sarah, Gratz, Paul Gerhard, Zahedipour, Fatemeh, Roig-Merino, Alicia, Antony, Justin S., Mezger, Markus
Publicado 2023

Challenges in Gene Therapy for Somatic Reverted Mosaicism in X-Linked Combined Immunodeficiency by CRISPR/Cas9 and Prime Editing

por Hou, Yujuan, Ureña-Bailén, Guillermo, Mohammadian Gol, Tahereh, Gratz, Paul Gerhard, Gratz, Hans Peter, Roig-Merino, Alicia, Antony, Justin S., Lamsfus-Calle, Andrés, Daniel-Moreno, Alberto, Handgretinger, Rupert, Mezger, Markus
Publicado 2022

Preclinical Evaluation of CRISPR-Edited CAR-NK-92 Cells for Off-the-Shelf Treatment of AML and B-ALL

por Ureña-Bailén, Guillermo, Dobrowolski, Jérôme-Maurice, Hou, Yujuan, Dirlam, Alicia, Roig-Merino, Alicia, Schleicher, Sabine, Atar, Daniel, Seitz, Christian, Feucht, Judith, Antony, Justin S., Mohammadian Gol, Tahereh, Handgretinger, Rupert, Mezger, Markus
Publicado 2022

An episomal DNA vector platform for the persistent genetic modification of pluripotent stem cells and their differentiated progeny

por Roig-Merino, Alicia, Urban, Manuela, Bozza, Matthias, Peterson, Julia D., Bullen, Louise, Büchler-Schäff, Marleen, Stäble, Sina, van der Hoeven, Franciscus, Müller-Decker, Karin, McKay, Tristan R., Milsom, Michael D., Harbottle, Richard P.
Publicado 2021

Safe and stable generation of induced pluripotent stem cells using doggybone DNA vectors

por Thornton, Christopher D., Fielding, Stuart, Karbowniczek, Kinga, Roig-Merino, Alicia, Burrows, Alysha E., FitzPatrick, Lorna M., Sharaireh, Aseel, Tite, John P., Mole, Sara E., Harbottle, Richard P., Caproni, Lisa J., McKay, Tristan R.
Publicado 2021

Non-viral TRAC-knocked-in CD19(KI)CAR-T and gp350(KI)CAR-T cells tested against Burkitt lymphomas with type 1 or 2 EBV infection: In vivo cellular dynamics and potency

por Braun, Tobias, Pruene, Alina, Darguzyte, Milita, vom Stein, Alexander F., Nguyen, Phuong-Hien, Wagner, Dimitrios L., Kath, Jonas, Roig-Merino, Alicia, Heuser, Michael, Riehm, Lucas L., Schneider, Andreas, Awerkiew, Sabine, Talbot, Steven R., Bleich, André, Figueiredo, Constanca, Bornhäuser, Martin, Stripecke, Renata
Publicado 2023