SUMO Chain-Induced Dimerization Activates RNF4

por Rojas-Fernandez, Alejandro, Plechanovová, Anna, Hattersley, Neil, Jaffray, Ellis, Tatham, Michael H., Hay, Ronald T.
Publicado 2014

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

por Rojas-Fernandez, Alejandro, Herhaus, Lina, Macartney, Thomas, Lachaud, Christophe, Hay, Ronald T., Sapkota, Gopal P.
Publicado 2015

An affinity-directed protein missile system for targeted proteolysis

por Fulcher, Luke J., Macartney, Thomas, Bozatzi, Polyxeni, Hornberger, Annika, Rojas-Fernandez, Alejandro, Sapkota, Gopal P.
Publicado 2016

The Potential Role of SARS-COV-2 in the Pathogenesis of Parkinson's Disease

por Chaná-Cuevas, Pedro, Salles-Gándara, Philippe, Rojas-Fernandez, Alejandro, Salinas-Rebolledo, Constanza, Milán-Solé, Anna
Publicado 2020

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

por Jaffray, Ellis G., Tatham, Michael H., Mojsa, Barbara, Liczmanska, Magda, Rojas-Fernandez, Alejandro, Yin, Yili, Ball, Graeme, Hay, Ronald T.
Publicado 2023

DHX15 regulates CMTR1-dependent gene expression and cell proliferation

por Inesta-Vaquera, Francisco, Chaugule, Viduth K, Galloway, Alison, Chandler, Laurel, Rojas-Fernandez, Alejandro, Weidlich, Simone, Peggie, Mark, Cowling, Victoria H
Publicado 2018

Lack of Parkinsonian Pathology and Neurodegeneration in Mice After Long-Term Injections of a Proteasome Inhibitor in Olfactory Bulb and Amygdala

por del Rey, Natalia Lopez-Gonzalez, Balzano, Tiziano, Martin-Rodriguez, Lucia, Salinas-Rebolledo, Constanza, Trigo-Damas, Ines, Rojas-Fernandez, Alejandro, Alvarez-Erviti, Lydia, Blesa, Javier
Publicado 2021

Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains

por Lopez-Guerrero, Aida M., Tomas-Martin, Patricia, Pascual-Caro, Carlos, Macartney, Thomas, Rojas-Fernandez, Alejandro, Ball, Graeme, Alessi, Dario R., Pozo-Guisado, Eulalia, Martin-Romero, Francisco Javier
Publicado 2017

Indomethacin Induces Spermidine/Spermine-N(1)-Acetyltransferase-1 via the Nucleolin-CDK1 Axis and Synergizes with the Polyamine Oxidase Inhibitor Methoctramine in Lung Cancer Cells

por Buelvas, Neudo, Ugarte-Vio, Isidora, Asencio-Leal, Laura, Muñoz-Uribe, Matías, Martin-Martin, Antonia, Rojas-Fernández, Alejandro, Jara, José A., Tapia, Julio C., Arias, María Elena, López-Muñoz, Rodrigo A.
Publicado 2023

Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG

por Espinoza, Sofía, Arredondo, Sebastián B., Barake, Francisca, Carvajal, Francisco, Guerrero, Fernanda G., Segovia-Miranda, Fabian, Valenzuela, David M., Wyneken, Ursula, Rojas-Fernández, Alejandro, Cerpa, Waldo, Massardo, Loreto, Varela-Nallar, Lorena, González, Alfonso
Publicado 2020

Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival

por Vargas, Gabriela, Cortés, Omar, Arias-Muñoz, Eloisa, Hernández, Sergio, Cerda-Troncoso, Cristobal, Hernández, Laura, González, Alexis E., Tatham, Michael H., Bustamante, Hianara A., Retamal, Claudio, Cancino, Jorge, Varas-Godoy, Manuel, Hay, Ronald T., Rojas-Fernández, Alejandro, Cavieres, Viviana A., Burgos, Patricia V.
Publicado 2022

The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport

por Bustamante, Hianara A, Cereceda, Karina, González, Alexis E, Valenzuela, Guillermo E, Cheuquemilla, Yorka, Hernández, Sergio, Arias-Muñoz, Eloisa, Cerda-Troncoso, Cristóbal, Bandau, Susanne, Soza, Andrea, Kausel, Gudrun, Kerr, Bredford, Mardones, Gonzalo A, Cancino, Jorge, Hay, Ronald T, Rojas-Fernandez, Alejandro, Burgos, Patricia V
Publicado 2020

Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody

por Valenzuela Nieto, Guillermo, Jara, Ronald, Watterson, Daniel, Modhiran, Naphak, Amarilla, Alberto A., Himelreichs, Johanna, Khromykh, Alexander A., Salinas-Rebolledo, Constanza, Pinto, Teresa, Cheuquemilla, Yorka, Margolles, Yago, López González del Rey, Natalia, Miranda-Chacon, Zaray, Cuevas, Alexei, Berking, Anne, Deride, Camila, González-Moraga, Sebastián, Mancilla, Héctor, Maturana, Daniel, Langer, Andreas, Toledo, Juan Pablo, Müller, Ananda, Uberti, Benjamín, Krall, Paola, Ehrenfeld, Pamela, Blesa, Javier, Chana-Cuevas, Pedro, Rehren, German, Schwefel, David, Fernandez, Luis Ángel, Rojas-Fernandez, Alejandro
Publicado 2021

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

por Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J., Khromykh, Alexander A., Chappell, Keith J., Watterson, Daniel, Woodruff, Trent M.
Publicado 2022

A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants

por Modhiran, Naphak, Lauer, Simon Malte, Amarilla, Alberto A., Hewins, Peter, Lopes van den Broek, Sara Irene, Low, Yu Shang, Thakur, Nazia, Liang, Benjamin, Nieto, Guillermo Valenzuela, Jung, James, Paramitha, Devina, Isaacs, Ariel, Sng, Julian D.J., Song, David, Jørgensen, Jesper Tranekjær, Cheuquemilla, Yorka, Bürger, Jörg, Andersen, Ida Vang, Himelreichs, Johanna, Jara, Ronald, MacLoughlin, Ronan, Miranda-Chacon, Zaray, Chana-Cuevas, Pedro, Kramer, Vasko, Spahn, Christian, Mielke, Thorsten, Khromykh, Alexander A., Munro, Trent, Jones, Martina L., Young, Paul R., Chappell, Keith, Bailey, Dalan, Kjaer, Andreas, Herth, Matthias Manfred, Jurado, Kellie Ann, Schwefel, David, Rojas-Fernandez, Alejandro, Watterson, Daniel
Publicado 2023