ODP178 Development and Validation of a Noncompetitive Immunoassay Optimized for the Assessment of Pharmacokinetics of Biologically Active Efruxifermin in Humans

por Hurst, Jacob, Johnson, Derrick, Tillman, Erik, Rolph, Timothy, Thystrup, Jennifer, Bowsher, Ronald
Publicado 2022

Do ENSO and Coastal Development Enhance Coastal Burial of Terrestrial Carbon?

por Macreadie, Peter I., Rolph, Timothy C., Boyd, Ron, Schröder-Adams, Claudia J., Skilbeck, Charles G.
Publicado 2015

Generation of Affinity Purified Antibody Reagents for Specific Determination of Efruxifermin in Biological Matrices

por Kinne, Adam S, Abdeen, Sanofar J, Parmer, Elijah S, Thystrup, Jennifer A, Tillman, Erik J, Rolph, Timothy P, Bowsher, Ronald R
Publicado 2021

FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance

por Bernardo, Barbara, Lu, Min, Bandyopadhyay, Gautam, Li, Pingping, Zhou, Yingjiang, Huang, Jie, Levin, Nancy, Tomas, Eva M., Calle, Roberto A., Erion, Derek M., Rolph, Timothy P., Brenner, Martin, Talukdar, Saswata
Publicado 2015

A randomized, double-blind, placebo-controlled phase IIa trial of efruxifermin for patients with compensated NASH cirrhosis

por Harrison, Stephen A., Ruane, Peter J., Freilich, Bradley, Neff, Guy, Patil, Rashmee, Behling, Cynthia, Hu, Chen, Shringarpure, Reshma, de Temple, Brittany, Fong, Erica, Tillman, Erik J., Rolph, Timothy, Cheng, Andrew, Yale, Kitty
Publicado 2022

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

por White, Phillip J., Lapworth, Amanda L., An, Jie, Wang, Liping, McGarrah, Robert W., Stevens, Robert D., Ilkayeva, Olga, George, Tabitha, Muehlbauer, Michael J., Bain, James R., Trimmer, Jeff K., Brosnan, M. Julia, Rolph, Timothy P., Newgard, Christopher B.
Publicado 2016

The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic Rats

por Erion, Derek M., Lapworth, Amanda, Amor, Paul A., Bai, Guoyun, Vera, Nicholas B., Clark, Ronald W., Yan, Qingyun, Zhu, Yimin, Ross, Trenton T., Purkal, Julie, Gorgoglione, Matthew, Zhang, Guodong, Bonato, Vinicius, Baker, Levenia, Barucci, Nicole, D’Aquila, Theresa, Robertson, Alan, Aiello, Robert J., Yan, Jiangli, Trimmer, Jeff, Rolph, Timothy P., Pfefferkorn, Jeffrey A.
Publicado 2014

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)

por Huard, Kim, Brown, Janice, Jones, Jessica C., Cabral, Shawn, Futatsugi, Kentaro, Gorgoglione, Matthew, Lanba, Adhiraj, Vera, Nicholas B., Zhu, Yimin, Yan, Qingyun, Zhou, Yingjiang, Vernochet, Cecile, Riccardi, Keith, Wolford, Angela, Pirman, David, Niosi, Mark, Aspnes, Gary, Herr, Michael, Genung, Nathan E., Magee, Thomas V., Uccello, Daniel P., Loria, Paula, Di, Li, Gosset, James R., Hepworth, David, Rolph, Timothy, Pfefferkorn, Jeffrey A., Erion, Derek M.
Publicado 2015