The molecular species responsible for α(1)‐antitrypsin deficiency are suppressed by a small molecule chaperone

por Ronzoni, Riccardo, Heyer‐Chauhan, Nina, Fra, Annamaria, Pearce, Andrew C., Rüdiger, Martin, Miranda, Elena, Irving, James A., Lomas, David A.
Publicado 2020

The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant

por Ronzoni, Riccardo, Ferrarotti, Ilaria, D’Acunto, Emanuela, Balderacchi, Alice M., Ottaviani, Stefania, Lomas, David A., Irving, James A., Miranda, Elena, Fra, Annamaria
Publicado 2021

Three New Alpha1-Antitrypsin Deficiency Variants Help to Define a C-Terminal Region Regulating Conformational Change and Polymerization

por Fra, Anna M., Gooptu, Bibek, Ferrarotti, Ilaria, Miranda, Elena, Scabini, Roberta, Ronzoni, Riccardo, Benini, Federica, Corda, Luciano, Medicina, Daniela, Luisetti, Maurizio, Schiaffonati, Luisa
Publicado 2012

Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin

por Laffranchi, Mattia, Elliston, Emma L.K., Miranda, Elena, Perez, Juan, Ronzoni, Riccardo, Jagger, Alistair M., Heyer-Chauhan, Nina, Brantly, Mark L., Fra, Annamaria, Lomas, David A., Irving, James A.
Publicado 2020

Development of a small molecule that corrects misfolding and increases secretion of Z α(1)‐antitrypsin

por Lomas, David A, Irving, James A, Arico‐Muendel, Christopher, Belyanskaya, Svetlana, Brewster, Andrew, Brown, Murray, Chung, Chun‐wa, Dave, Hitesh, Denis, Alexis, Dodic, Nerina, Dossang, Anthony, Eddershaw, Peter, Klimaszewska, Diana, Haq, Imran, Holmes, Duncan S, Hutchinson, Jonathan P, Jagger, Alistair M, Jakhria, Toral, Jigorel, Emilie, Liddle, John, Lind, Ken, Marciniak, Stefan J, Messer, Jeff, Neu, Margaret, Olszewski, Allison, Ordonez, Adriana, Ronzoni, Riccardo, Rowedder, James, Rüdiger, Martin, Skinner, Steve, Smith, Kathrine J, Terry, Rebecca, Trottet, Lionel, Uings, Iain, Wilson, Steve, Zhu, Zhengrong, Pearce, Andrew C
Publicado 2021