Biochemical heterogeneity and developmental varieties in T-cell leukemia

por Chakraborty, Arup K., Roose, Jeroen P.
Publicado 2013

Protocol for Comprehensive Synthetic Lethality Screens

por Romero-Moya, Damia, Roose, Jeroen P.
Publicado 2020

Unexpected insights for anti-EGFR cancer therapy

por Depeille, Philippe, Warren, Robert S., Roose, Jeroen P.
Publicado 2015

Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells

por Jun, Jesse E., Rubio, Ignacio, Roose, Jeroen P.
Publicado 2013

Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer

por Samocha, Alexandr, Doh, Hanna, Kessenbrock, Kai, Roose, Jeroen P.
Publicado 2019

Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells

por Myers, Darienne R., Norlin, Emilia, Vercoulen, Yvonne, Roose, Jeroen P.
Publicado 2019

Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models

por Li, P. Jonathan, Roose, Jeroen P., Jablons, David M., Kratz, Johannes R.
Publicado 2021

Basal LAT-diacylglycerol-RasGRP1 Signals in T Cells Maintain TCRα Gene Expression

por Markegard, Evan, Trager, Evan, Yang, Chih-wen Ou, Zhang, Weiguo, Weiss, Arthur, Roose, Jeroen P.
Publicado 2011

Protocol for Barcoding T Cells Combined with Timed Stimulations

por Kulhanek, Kayla R., Myers, Darienne R., Ksionda, Olga, Vercoulen, Yvonne, Romero-Moya, Damia, Roose, Jeroen P.
Publicado 2020

Stim1, PKCδ and RasGRP proteins set a threshold for pro-apoptotic Erk signaling during B cell development

por Limnander, Andre, Depeille, Philippe, Freedman, Tanya S., Liou, Jen, Leitges, Michael, Kurosaki, Tomohiro, Roose, Jeroen P., Weiss, Arthur
Publicado 2011

T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression

por Roose, Jeroen P, Diehn, Maximilian, Tomlinson, Michael G, Lin, Joseph, Alizadeh, Ash A, Botstein, David, Brown, Patrick O, Weiss, Arthur
Publicado 2003

Increased baseline RASGRP1 signals Enhance Stem Cell Fitness during Native Hematopoiesis

por Karra, Laila, Romero-Moya, Damia, Ksionda, Olga, Krush, Milana, Gu, Zhaohui, Mues, Marsilius, Depeille, Philippe, Mullighan, Charles, Roose, Jeroen P.
Publicado 2020

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

por Vercoulen, Yvonne, Kondo, Yasushi, Iwig, Jeffrey S, Janssen, Axel B, White, Katharine A, Amini, Mojtaba, Barber, Diane L, Kuriyan, John, Roose, Jeroen P
Publicado 2017

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

por Iwig, Jeffrey S, Vercoulen, Yvonne, Das, Rahul, Barros, Tiago, Limnander, Andre, Che, Yan, Pelton, Jeffrey G, Wemmer, David E, Roose, Jeroen P, Kuriyan, John
Publicado 2013

Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy

por Ksionda, Olga, Mues, Marsilius, Wandler, Anica M., Donker, Lisa, Tenhagen, Milou, Jun, Jesse, Ducker, Gregory S., Matlawska-Wasowska, Ksenia, Shannon, Kevin, Shokat, Kevan M., Roose, Jeroen P.
Publicado 2018

One-way membrane trafficking of SOS in receptor-triggered Ras activation

por Christensen, Sune M., Tu, Hsiung-Lin, Jun, Jesse E., Alvarez, Steven, Triplet, Meredith G., Iwig, Jeffrey S., Yadav, Kamlesh K., Bar-Sagi, Dafna, Roose, Jeroen P., Groves, Jay T.
Publicado 2016

Nras(Q61R/+) and Kras(−/−) cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors

por Wen, Zhi, Yun, Grant, Hebert, Alexander, Kong, Guangyao, Ranheim, Erik A., Finn, Remington, Rajagoplan, Adhithi, Li, Shuyi, Zhou, Yun, Yu, Mei, Damnernsawad, Alisa, Roose, Jeroen P., Coon, Joshua J., Wen, Renren, Wang, Demin, Zhang, Jing
Publicado 2021

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity

por Baars, Matthijs J.D., Douma, Thera, Simeonov, Dimitre R., Myers, Darienne R., Kulhanek, Kayla, Banerjee, Saikat, Zwakenberg, Susan, Baltissen, Marijke P., Amini, Mojtaba, de Roock, Sytze, van Wijk, Femke, Vermeulen, Michiel, Marson, Alexander, Roose, Jeroen P., Vercoulen, Yvonne
Publicado 2020

Response and Resistance to MEK Inhibition in Leukaemias Initiated by Hyperactive Ras

por Lauchle, Jennifer O., Kim, Doris, Le, Doan T., Akagi, Keiko, Crone, Michael, Krisman, Kimberly, Warner, Kegan, Bonifas, Jeannette M., Li, Qing, Coakley, Kristin M., Diaz-Flores, Ernesto, Gorman, Matthew, Przybranowski, Sally, Tran, Mary, Kogan, Scott C., Roose, Jeroen P., Copeland, Neal, Jenkins, Nancy, Parada, Luis, Wolff, Linda, Sebolt-Leopold, Judith, Shannon, Kevin
Publicado 2009

Immediate myeloid depot for SARS-CoV-2 in the human lung

por Magnen, Mélia, You, Ran, Rao, Arjun A., Davis, Ryan T., Rodriguez, Lauren, Simoneau, Camille R., Hysenaj, Lisiena, Hu, Kenneth H., Love, Christina, Woodruff, Prescott G., Erle, David J., Hendrickson, Carolyn M., Calfee, Carolyn S., Matthay, Michael A., Roose, Jeroen P., Sil, Anita, Ott, Melanie, Langelier, Charles R., Krummel, Matthew F., Looney, Mark R.
Publicado 2022