Resources for the design of CRISPR gene editing experiments

por Graham, Daniel B., Root, David E.
Publicado 2015

Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression

por Gohil, Vishal M., Nilsson, Roland, Belcher-Timme, Casey A., Luo, Biao, Root, David E., Mootha, Vamsi K.
Publicado 2010

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool

por Donovan, Katherine F., Hegde, Mudra, Sullender, Meagan, Vaimberg, Emma W., Johannessen, Cory M., Root, David E., Doench, John G.
Publicado 2017

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

por Rosenbluh, Joseph, Xu, Han, Harrington, William, Gill, Stanley, Wang, Xiaoxing, Vazquez, Francisca, Root, David E., Tsherniak, Aviad, Hahn, William C.
Publicado 2017

Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects

por Dempster, Joshua M., Boyle, Isabella, Vazquez, Francisca, Root, David E., Boehm, Jesse S., Hahn, William C., Tsherniak, Aviad, McFarland, James M.
Publicado 2021

Vps18 contributes to phagosome membrane integrity in Mycobacterium tuberculosis-infected macrophages

por Jani, Charul, Marsh, Amanda, Uchil, Pooja, Jain, Neha, Baskir, Zach R., Glover, Owen T., Root, David E., Doench, John G., Barczak, Amy K.
Publicado 2023

A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression

por Oh, Hyung Suk, Bryant, Kevin F., Nieland, Thomas J. F., Mazumder, Aprotim, Bagul, Mukta, Bathe, Mark, Root, David E., Knipe, David M.
Publicado 2014

High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons

por Nieland, Thomas J. F., Logan, David J., Saulnier, Jessica, Lam, Daniel, Johnson, Caroline, Root, David E., Carpenter, Anne E., Sabatini, Bernardo L.
Publicado 2014

Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

por Singh, Shantanu, Wu, Xiaoyun, Ljosa, Vebjorn, Bray, Mark-Anthony, Piccioni, Federica, Root, David E., Doench, John G., Boehm, Jesse S., Carpenter, Anne E.
Publicado 2015

Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

por Guyon, Clotilde, Jmari, Nada, Padonou, Francine, Li, Yen-Chin, Ucar, Olga, Fujikado, Noriyuki, Coulpier, Fanny, Blanchet, Christophe, Root, David E, Giraud, Matthieu
Publicado 2020

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

por Ebert, Benjamin L., Pretz, Jennifer, Bosco, Jocelyn, Chang, Cindy Y., Tamayo, Pablo, Galili, Naomi, Raza, Azra, Root, David E., Attar, Eyal, Ellis, Steven R., Golub, Todd R.
Publicado 2008

Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map

por Smith, Ian, Greenside, Peyton G., Natoli, Ted, Lahr, David L., Wadden, David, Tirosh, Itay, Narayan, Rajiv, Root, David E., Golub, Todd R., Subramanian, Aravind, Doench, John G.
Publicado 2017

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

por Johannessen, Cory M., Johnson, Laura A., Piccioni, Federica, Townes, Aisha, Frederick, Dennie T., Donahue, Melanie K., Narayan, Rajiv, Flaherty, Keith T., Wargo, Jennifer A., Root, David E., Garraway, Levi A.
Publicado 2013

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

por Sanson, Kendall R., Hanna, Ruth E., Hegde, Mudra, Donovan, Katherine F., Strand, Christine, Sullender, Meagan E., Vaimberg, Emma W., Goodale, Amy, Root, David E., Piccioni, Federica, Doench, John G.
Publicado 2018

TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity

por Ramirez-Ortiz, Zaida G., Prasad, Amit, Griffith, Jason W., Pendergraft, William F., Cowley, Glenn S., Root, David E., Tai, Melissa, Luster, Andrew D., Khoury, Joseph El, Hacohen, Nir, Means, Terry K.
Publicado 2015

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

por Doench, John G., Fusi, Nicolo, Sullender, Meagan, Hegde, Mudra, Vaimberg, Emma W., Donovan, Katherine F., Smith, Ian, Tothova, Zuzana, Wilen, Craig, Orchard, Robert, Virgin, Herbert W., Listgarten, Jennifer, Root, David E.
Publicado 2016

Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal

por Krill-Burger, J. Michael, Dempster, Joshua M., Borah, Ashir A., Paolella, Brenton R., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C., McFarland, James M., Vazquez, Francisca, Tsherniak, Aviad
Publicado 2023

The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection

por Filone, Claire Marie, Caballero, Ignacio S., Dower, Ken, Mendillo, Marc L., Cowley, Glenn S., Santagata, Sandro, Rozelle, Daniel K., Yen, Judy, Rubins, Kathleen H., Hacohen, Nir, Root, David E., Hensley, Lisa E., Connor, John
Publicado 2014

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst

por Graham, Daniel B., Becker, Christine E., Doan, Aivi, Goel, Gautam, Villablanca, Eduardo J., Knights, Dan, Mok, Amanda, Ng, Aylwin C.Y., Doench, John G., Root, David E., Clish, Clary B., Xavier, Ramnik J.
Publicado 2015

CK1ε Is Required for Breast Cancers Dependent on β-Catenin Activity

por Kim, So Young, Dunn, Ian F., Firestein, Ron, Gupta, Piyush, Wardwell, Leslie, Repich, Kara, Schinzel, Anna C., Wittner, Ben, Silver, Serena J., Root, David E., Boehm, Jesse S., Ramaswamy, Sridhar, Lander, Eric S., Hahn, William C.
Publicado 2010