Neurodegenerative Lysosomal Storage Disorders: TPC2 Comes to the Rescue!

por Prat Castro, Sandra, Kudrina, Veronika, Jaślan, Dawid, Böck, Julia, Scotto Rosato, Anna, Grimm, Christian
Publicado 2022

Computational Assessment of Facial Expression Production in ASD Children

por Leo, Marco, Carcagnì, Pierluigi, Distante, Cosimo, Spagnolo, Paolo, Mazzeo, Pier Luigi, Rosato, Anna Chiara, Petrocchi, Serena, Pellegrino, Chiara, Levante, Annalisa, De Lumè, Filomena, Lecciso, Flavia
Publicado 2018

Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors

por Rühl, Philipp, Rosato, Anna Scotto, Urban, Nicole, Gerndt, Susanne, Tang, Rachel, Abrahamian, Carla, Leser, Charlotte, Sheng, Jiansong, Jha, Archana, Vollmer, Günter, Schaefer, Michael, Bracher, Franz, Grimm, Christian
Publicado 2021

Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2

por Netcharoensirisuk, Ponsawan, Abrahamian, Carla, Tang, Rachel, Chen, Cheng-Chang, Rosato, Anna Scotto, Beyers, Wyatt, Chao, Yu-Kai, Filippini, Antonio, Di Pietro, Santiago, Bartel, Karin, Biel, Martin, Vollmar, Angelika M., Umehara, Kaoru, De-Eknamkul, Wanchai, Grimm, Christian
Publicado 2021

Segregated cation flux by TPC2 biases Ca(2+) signaling through lysosomes

por Yuan, Yu, Jaślan, Dawid, Rahman, Taufiq, Bolsover, Stephen R., Arige, Vikas, Wagner, Larry E., Abrahamian, Carla, Tang, Rachel, Keller, Marco, Hartmann, Jonas, Rosato, Anna S., Weiden, Eva-Maria, Bracher, Franz, Yule, David I., Grimm, Christian, Patel, Sandip
Publicado 2022

Lysosomal calcium signaling regulates autophagy via calcineurin and TFEB

por Medina, Diego L., Di Paola, Simone, Peluso, Ivana, Armani, Andrea, De Stefani, Diego, Venditti, Rossella, Montefusco, Sandro, Scotto-Rosato, Anna, Prezioso, Carolina, Forrester, Alison, Settembre, Carmine, Wang, Wuyang, Gao, Qiong, Xu, Haoxing, Sandri, Marco, Rizzuto, Rosario, De Matteis, Maria Antonietta, Ballabio, Andrea
Publicado 2015

Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

por Plesch, Eva, Chen, Cheng-Chang, Butz, Elisabeth, Scotto Rosato, Anna, Krogsaeter, Einar K, Yinan, Hua, Bartel, Karin, Keller, Marco, Robaa, Dina, Teupser, Daniel, Holdt, Lesca M, Vollmar, Angelika M, Sippl, Wolfgang, Puertollano, Rosa, Medina, Diego, Biel, Martin, Wahl-Schott, Christian, Bracher, Franz, Grimm, Christian
Publicado 2018

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

por Gerndt, Susanne, Chen, Cheng-Chang, Chao, Yu-Kai, Yuan, Yu, Burgstaller, Sandra, Scotto Rosato, Anna, Krogsaeter, Einar, Urban, Nicole, Jacob, Katharina, Nguyen, Ong Nam Phuong, Miller, Meghan T, Keller, Marco, Vollmar, Angelika M, Gudermann, Thomas, Zierler, Susanna, Schredelseker, Johann, Schaefer, Michael, Biel, Martin, Malli, Roland, Wahl-Schott, Christian, Bracher, Franz, Patel, Sandip, Grimm, Christian
Publicado 2020

Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype

por Soldati, Chiara, Lopez‐Fabuel, Irene, Wanderlingh, Luca G, Garcia‐Macia, Marina, Monfregola, Jlenia, Esposito, Alessandra, Napolitano, Gennaro, Guevara‐Ferrer, Marta, Scotto Rosato, Anna, Krogsaeter, Einar K, Paquet, Dominik, Grimm, Christian M, Montefusco, Sandro, Braulke, Thomas, Storch, Stephan, Mole, Sara E, De Matteis, Maria A, Ballabio, Andrea, Sampaio, Julio L, McKay, Tristan, Johannes, Ludger, Bolaños, Juan P, Medina, Diego L
Publicado 2021

TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann–Pick type C1, and Batten disease

por Scotto Rosato, Anna, Krogsaeter, Einar K, Jaślan, Dawid, Abrahamian, Carla, Montefusco, Sandro, Soldati, Chiara, Spix, Barbara, Pizzo, Maria Teresa, Grieco, Giuseppina, Böck, Julia, Wyatt, Amanda, Wünkhaus, Daniela, Passon, Marcel, Stieglitz, Marc, Keller, Marco, Hermey, Guido, Markmann, Sandra, Gruber‐Schoffnegger, Doris, Cotman, Susan, Johannes, Ludger, Crusius, Dennis, Boehm, Ulrich, Wahl‐Schott, Christian, Biel, Martin, Bracher, Franz, De Leonibus, Elvira, Polishchuk, Elena, Medina, Diego L, Paquet, Dominik, Grimm, Christian
Publicado 2022

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

por Spix, Barbara, Butz, Elisabeth S., Chen, Cheng-Chang, Rosato, Anna Scotto, Tang, Rachel, Jeridi, Aicha, Kudrina, Veronika, Plesch, Eva, Wartenberg, Philipp, Arlt, Elisabeth, Briukhovetska, Daria, Ansari, Meshal, Günsel, Gizem Günes, Conlon, Thomas M., Wyatt, Amanda, Wetzel, Sandra, Teupser, Daniel, Holdt, Lesca M., Ectors, Fabien, Boekhoff, Ingrid, Boehm, Ulrich, García-Añoveros, Jaime, Saftig, Paul, Giera, Martin, Kobold, Sebastian, Schiller, Herbert B., Zierler, Susanna, Gudermann, Thomas, Wahl-Schott, Christian, Bracher, Franz, Yildirim, Ali Önder, Biel, Martin, Grimm, Christian
Publicado 2022