ADME Considerations and Bioanalytical Strategies for Pharmacokinetic Assessments of Antibody-Drug Conjugates

por Mou, Si, Huang, Yue, Rosenbaum, Anton I.
Publicado 2018

Differences in levels of phosphatidylinositols in healthy and stable Coronary Artery Disease subjects revealed by HILIC-MRM method with SERRF normalization

por Huang, Yue, Mu, Ruipeng, Wen, David, Grimsby, Joseph S., Liang, Meina, Rosenbaum, Anton I.
Publicado 2021

Robust and High-Throughput Analytical Flow Proteomics Analysis of Cynomolgus Monkey and Human Matrices With Zeno SWATH Data-Independent Acquisition

por Sun, Weiwen, Lin, Yuan, Huang, Yue, Chan, Josolyn, Terrillon, Sonia, Rosenbaum, Anton I., Contrepois, Kévin
Publicado 2023

Bioanalytical Methods and Strategic Perspectives Addressing the Rising Complexity of Novel Bioconjugates and Delivery Routes for Biotherapeutics

por Mu, Ruipeng, Yuan, Jiaqi, Huang, Yue, Meissen, John K., Mou, Si, Liang, Meina, Rosenbaum, Anton I.
Publicado 2022

Multiplex LC-MS/MS Assays for Clinical Bioanalysis of MEDI4276, an Antibody-Drug Conjugate of Tubulysin Analogue Attached via Cleavable Linker to a Biparatopic Humanized Antibody a...

por Faria, Morse, Peay, Marlking, Lam, Brandon, Ma, Eric, Yuan, Moucun, Waldron, Michael, Mylott, William R., Liang, Meina, Rosenbaum, Anton I.
Publicado 2019

Multiplex Bioanalytical Methods for Comprehensive Characterization and Quantification of the Unique Complementarity-Determining-Region Deamidation of MEDI7247, an Anti-ASCT2 Pyrrol...

por Huang, Yue, Yuan, Jiaqi, Mu, Ruipeng, Kubiak, Robert J., Ball, Kathryn, Cao, Mingyan, Hussmann, G. Patrick, de Mel, Niluka, Liu, Dengfeng, Roskos, Lorin K., Liang, Meina, Rosenbaum, Anton I.
Publicado 2023

Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation

por Tyagi, Puneet, Patel, Chandresh, Gibson, Kimberly, MacDougall, Fiona, Pechenov, Sergei Y., Will, Sarah, Revell, Jefferson, Huang, Yue, Rosenbaum, Anton I., Balic, Kemal, Maharoof, Umar, Grimsby, Joseph, Subramony, J. Anand
Publicado 2023

Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease

por Pechenov, Sergei, Revell, Jefferson, Will, Sarah, Naylor, Jacqueline, Tyagi, Puneet, Patel, Chandresh, Liang, Lihuan, Tseng, Leo, Huang, Yue, Rosenbaum, Anton I., Balic, Kemal, Konkar, Anish, Grimsby, Joseph, Subramony, J. Anand
Publicado 2021

First-in-Human, Phase 1 Dose-Escalation Study of Biparatopic Anti-HER2 Antibody–Drug Conjugate MEDI4276 in Patients with HER2-positive Advanced Breast or Gastric Cancer

por Pegram, Mark D., Hamilton, Erika P., Tan, Antoinette R., Storniolo, Anna Maria, Balic, Kemal, Rosenbaum, Anton I., Liang, Meina, He, Peng, Marshall, Shannon, Scheuber, Anita, Das, Mayukh, Patel, Manish R.
Publicado 2021

Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody Combination

por Mu, Ruipeng, Huang, Yue, Bouquet, Jerome, Yuan, Jiaqi, Kubiak, Robert J., Ma, Eric, Naser, Sami, Mylott, William R., Ismaiel, Omnia A., Wheeler, Aaron M., Burkart, Rebecca, Cortes, Diego F., Bruton, James, Arends, Rosalinda H., Liang, Meina, Rosenbaum, Anton I.
Publicado 2022

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in non-human primates and has an extended half-life in humans

por Loo, Yueh-Ming, McTamney, Patrick M., Arends, Rosalinda H., Abram, Michael E., Aksyuk, Anastasia A., Diallo, Seme, Flores, Daniel J., Kelly, Elizabeth J., Ren, Kuishu, Roque, Richard, Rosenthal, Kim, Streicher, Katie, Tuffy, Kevin M., Bond, Nicholas J., Cornwell, Owen, Bouquet, Jerome, Cheng, Lily I., Dunyak, James, Huang, Yue, Rosenbaum, Anton I., Reddy, Venkatesh Pilla, Andersen, Hanne, Carnahan, Robert H., Crowe, James E., Kuehne, Ana I., Herbert, Andrew S., Dye, John M., Bright, Helen, Kallewaard, Nicole L., Pangalos, Menelas N., Esser, Mark T.
Publicado 2022