Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis

por Julku, Ulrika, Xiong, Mengfei, Wik, Elin, Roshanbin, Sahar, Sehlin, Dag, Syvänen, Stina
Publicado 2022

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

por Meier, Silvio R., Syvänen, Stina, Hultqvist, Greta, Fang, Xiaotian T., Roshanbin, Sahar, Lannfelt, Lars, Neumann, Ulf, Sehlin, Dag
Publicado 2018

Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice

por Roshanbin, Sahar, Aniszewska, Agata, Gumucio, Astrid, Masliah, Eliezer, Erlandsson, Anna, Bergström, Joakim, Ingelsson, Martin, Ekmark-Lewén, Sara
Publicado 2021

Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney

por Roshanbin, Sahar, Lindberg, Frida A., Lekholm, Emilia, Eriksson, Mikaela M., Perland, Emelie, Åhlund, Johan, Raine, Amanda, Fredriksson, Robert
Publicado 2016

Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

por Roshanbin, Sahar, Julku, Ulrika, Xiong, Mengfei, Eriksson, Jonas, Masliah, Eliezer, Hultqvist, Greta, Bergström, Joakim, Ingelsson, Martin, Syvänen, Stina, Sehlin, Dag
Publicado 2022

(11)C-PiB and (124)I-Antibody PET Provide Differing Estimates of Brain Amyloid-β After Therapeutic Intervention

por Meier, Silvio R., Sehlin, Dag, Roshanbin, Sahar, Falk, Victoria Lim, Saito, Takashi, Saido, Takaomi C., Neumann, Ulf, Rokka, Johanna, Eriksson, Jonas, Syvänen, Stina
Publicado 2022

Leptin potentiates astrogenesis in the developing hypothalamus

por Rottkamp, Daniele M., Rudenko, Ivan A., Maier, Matthew T., Roshanbin, Sahar, Yulyaningsih, Ernie, Perez, Luz, Valdearcos, Martin, Chua, Streamson, Koliwad, Suneil K., Xu, Allison W.
Publicado 2015

PET Imaging in Preclinical Anti-Aβ Drug Development

por Syvänen, Stina, Meier, Silvio R., Roshanbin, Sahar, Xiong, Mengfei, Faresjö, Rebecca, Gustavsson, Tobias, Bonvicini, Gillian, Schlein, Eva, Aguilar, Ximena, Julku, Ulrika, Eriksson, Jonas, Sehlin, Dag
Publicado 2022

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer’s disease

por Gustavsson, Tobias, Metzendorf, Nicole G., Wik, Elin, Roshanbin, Sahar, Julku, Ulrika, Chourlia, Aikaterini, Nilsson, Per, Andersson, Ken G., Laudon, Hanna, Hultqvist, Greta, Syvänen, Stina, Sehlin, Dag
Publicado 2023

B(0)AT2 (SLC6A15) Is Localized to Neurons and Astrocytes, and Is Involved in Mediating the Effect of Leucine in the Brain

por Hägglund, Maria G. A., Roshanbin, Sahar, Löfqvist, Erik, Hellsten, Sofie V., Nilsson, Victor C. O., Todkar, Aniruddha, Zhu, Yinan, Stephansson, Olga, Drgonova, Jana, Uhl, George R., Schiöth, Helgi B., Fredriksson, Robert
Publicado 2013

The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain

por Fredriksson, Robert, Sreedharan, Smitha, Nordenankar, Karin, Alsiö, Johan, Lindberg, Frida A., Hutchinson, Ashley, Eriksson, Anders, Roshanbin, Sahar, Ciuculete, Diana M., Klockars, Anica, Todkar, Aniruddha, Hägglund, Maria G., Hellsten, Sofie V., Hindlycke, Viktoria, Västermark, Åke, Shevchenko, Ganna, Olivo, Gaia, K, Cheng, Kullander, Klas, Moazzami, Ali, Bergquist, Jonas, Olszewski, Pawel K., Schiöth, Helgi B.
Publicado 2019