Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington’s disease mice

por Mégret, Lucile, Nair, Satish Sasidharan, Dancourt, Julia, Aaronson, Jeff, Rosinski, Jim, Neri, Christian
Publicado 2020

Genetic cooperativity in multi-layer networks implicates cell survival and senescence in the striatum of Huntington’s disease mice synchronous to symptoms

por Bigan, Erwan, Sasidharan Nair, Satish, Lejeune, François-Xavier, Fragnaud, Hélissande, Parmentier, Frédéric, Mégret, Lucile, Verny, Marc, Aaronson, Jeff, Rosinski, Jim, Neri, Christian
Publicado 2020

MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice

por Langfelder, Peter, Gao, Fuying, Wang, Nan, Howland, David, Kwak, Seung, Vogt, Thomas F., Aaronson, Jeffrey S., Rosinski, Jim, Coppola, Giovanni, Horvath, Steve, Yang, X. William
Publicado 2018

Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

por Megret, Lucile, Gris, Barbara, Sasidharan Nair, Satish, Cevost, Jasmin, Wertz, Mary, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F, Wilkinson, Hilary, Heiman, Myriam, Neri, Christian
Publicado 2021

Dysfunction of the CNS-Heart Axis in Mouse Models of Huntington's Disease

por Mielcarek, Michal, Inuabasi, Linda, Bondulich, Marie K., Muller, Thomas, Osborne, Georgina F., Franklin, Sophie A., Smith, Donna L., Neueder, Andreas, Rosinski, Jim, Rattray, Ivan, Protti, Andrea, Bates, Gillian P.
Publicado 2014

Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

por Horvath, Steve, Langfelder, Peter, Kwak, Seung, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F., Eszes, Marika, Faull, Richard L.M., Curtis, Maurice A., Waldvogel, Henry J., Choi, Oi-Wa, Tung, Spencer, Vinters, Harry V., Coppola, Giovanni, Yang, X. William
Publicado 2016

Transcriptional regulatory networks underlying gene expression changes in Huntington's disease

por Ament, Seth A, Pearl, Jocelynn R, Cantle, Jeffrey P, Bragg, Robert M, Skene, Peter J, Coffey, Sydney R, Bergey, Dani E, Wheeler, Vanessa C, MacDonald, Marcy E, Baliga, Nitin S, Rosinski, Jim, Hood, Leroy E, Carroll, Jeffrey B, Price, Nathan D
Publicado 2018

Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice

por Langfelder, Peter, Cantle, Jeffrey P., Chatzopoulou, Doxa, Wang, Nan, Gao, Fuying, Al-Ramahi, Ismael, Lu, Xiao-Hong, Ramos, Eliana Marisa, El-Zein, Karla, Zhao, Yining, Deverasetty, Sandeep, Tebbe, Andreas, Schaab, Christoph, Lavery, Daniel J., Howland, David, Kwak, Seung, Botas, Juan, Aaronson, Jeffrey S., Rosinski, Jim, Coppola, Giovanni, Horvath, Steve, Yang, X. William
Publicado 2016

DNA methylation study of Huntington’s disease and motor progression in patients and in animal models

por Lu, Ake T., Narayan, Pritika, Grant, Matthew J., Langfelder, Peter, Wang, Nan, Kwak, Seung, Wilkinson, Hilary, Chen, Richard Z., Chen, Jian, Simon Bawden, C., Rudiger, Skye R., Ciosi, Marc, Chatzi, Afroditi, Maxwell, Alastair, Hore, Timothy A., Aaronson, Jeff, Rosinski, Jim, Preiss, Alicia, Vogt, Thomas F., Coppola, Giovanni, Monckton, Darren, Snell, Russell G., William Yang, X., Horvath, Steve
Publicado 2020

Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model

por Marchionini, Deanna M., Liu, Jeh-Ping, Ambesi-Impiombato, Alberto, Kerker, Kimberly, Cirillo, Kim, Bansal, Mukesh, Mushlin, Rich, Brunner, Daniela, Ramboz, Sylvie, Kwan, Mei, Kuhlbrodt, Kirsten, Tillack, Karsten, Peters, Finn, Rauhala, Leena, Obenauer, John, Greene, Jonathan R., Hartl, Christopher, Khetarpal, Vinod, Lager, Brenda, Rosinski, Jim, Aaronson, Jeff, Alam, Morshed, Signer, Ethan, Muñoz-Sanjuán, Ignacio, Howland, David, Zeitlin, Scott O.
Publicado 2022

Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington’s disease mice

por Bondulich, Marie K., Jolinon, Nelly, Osborne, Georgina F., Smith, Edward J., Rattray, Ivan, Neueder, Andreas, Sathasivam, Kirupa, Ahmed, Mhoriam, Ali, Nadira, Benjamin, Agnesska C., Chang, Xiaoli, Dick, James R. T., Ellis, Matthew, Franklin, Sophie A., Goodwin, Daniel, Inuabasi, Linda, Lazell, Hayley, Lehar, Adam, Richard-Londt, Angela, Rosinski, Jim, Smith, Donna L., Wood, Tobias, Tabrizi, Sarah J., Brandner, Sebastian, Greensmith, Linda, Howland, David, Munoz-Sanjuan, Ignacio, Lee, Se-Jin, Bates, Gillian P.
Publicado 2017