Physiologically Based Pharmacokinetics Is Impacting Drug Development and Regulatory Decision Making

por Rowland, M, Lesko, LJ, Rostami-Hodjegan, A
Publicado 2015

Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information

por Mishra, H, Polak, S, Jamei, M, Rostami-Hodjegan, A
Publicado 2014

A PBPK Model to Predict Disposition of CYP3A-Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction

por Ke, A B, Nallani, S C, Zhao, P, Rostami-Hodjegan, A, Unadkat, J D
Publicado 2012

Pharmacometrics and Systems Pharmacology Software Tutorials and Use: Comments and Guidelines for PSP Contributions

por Vicini, P, Friberg, L E, van der Graaf, P H, Rostami-Hodjegan, A
Publicado 2013

Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1-Related Variability in Pharmacodynamics of Rosuvastatin

por Rose, R H, Neuhoff, S, Abduljalil, K, Chetty, M, Rostami-Hodjegan, A, Jamei, M
Publicado 2014

A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine

por Jamei, M., Bajot, F., Neuhoff, S., Barter, Z., Yang, J., Rostami-Hodjegan, A., Rowland-Yeo, K.
Publicado 2013

Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1‐OH‐midazolam in morbidly obese and weight loss surgery patients

por Brill, MJE, Välitalo, PAJ, Darwich, AS, van Ramshorst, B, van Dongen, HPA, Rostami–Hodjegan, A, Danhof, M, Knibbe, CAJ
Publicado 2015

Evaluation of an In Silico PBPK Post-Bariatric Surgery Model through Simulating Oral Drug Bioavailability of Atorvastatin and Cyclosporine

por Darwich, A S, Pade, D, Rowland-Yeo, K, Jamei, M, Åsberg, A, Christensen, H, Ashcroft, D M, Rostami-Hodjegan, A
Publicado 2013

Systematic and quantitative assessment of the effect of chronic kidney disease on CYP2D6 and CYP3A4/5

por Yoshida, K, Sun, B, Zhang, L, Zhao, P, Abernethy, DR, Nolin, TD, Rostami‐Hodjegan, A, Zineh, I, Huang, S‐M
Publicado 2016

Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method

por Calvier, E. A. M., Krekels, E. H. J., Johnson, T. N., Rostami-Hodjegan, A., Tibboel, D., Knibbe, Catherijne A. J.
Publicado 2019

From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II—Sensitivity to Physiological and Physicochemical Properties

por Krekels, E H J, Johnson, T N, den Hoedt, S M, Rostami-Hodjegan, A, Danhof, M, Tibboel, D, Knibbe, C A J
Publicado 2012