From lymphocytes to sharks: V(D)J recombinase moves to the germline

por Roth, David B
Publicado 2000

Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition

por Lu, Catherine P., Posey, Jennifer E., Roth, David B.
Publicado 2008

Irradiation-Mediated Rescue of T Cell–Specific V(D)j Recombination and Thymocyte Differentiation in Severe Combined Immunodeficient Mice by Bone Marrow Cells

por Wang, Chiyu, Bogue, Molly A., Levitt, Jonathan M., Roth, David B.
Publicado 1999

Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways

por Arnal, Suzzette M., Holub, Abigail J., Salus, Sandra S., Roth, David B.
Publicado 2010

Target DNA Structure Plays a Critical Role in RAG Transposition

por Posey, Jennifer E, Pytlos, Malgorzata J, Sinden, Richard R, Roth, David B
Publicado 2006

A Streamlined Method for Detecting Structural Variants in Cancer Genomes by Short Read Paired-End Sequencing

por Mijušković, Martina, Brown, Stuart M., Tang, Zuojian, Lindsay, Cory R., Efstathiadis, Efstratios, Deriano, Ludovic, Roth, David B.
Publicado 2012

The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage

por Chaumeil, Julie, Micsinai, Mariann, Ntziachristos, Panagiotis, Roth, David B., Aifantis, Iannis, Kluger, Yuval, Deriano, Ludovic, Skok, Jane A.
Publicado 2013

RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of ‘alternative NHEJ’

por Gigi, Vered, Lewis, Susanna, Shestova, Olga, Mijušković, Martina, Deriano, Ludovic, Meng, Wenzhao, Luning Prak, Eline T., Roth, David B.
Publicado 2014

Actionable mutations in canine hemangiosarcoma

por Wang, Guannan, Wu, Ming, Maloneyhuss, Martha A., Wojcik, John, Durham, Amy C., Mason, Nicola J., Roth, David B.
Publicado 2017

Molecular subtypes in canine hemangiosarcoma reveal similarities with human angiosarcoma

por Wang, Guannan, Wu, Ming, Durham, Amy C., Radaelli, Enrico, Mason, Nicola J., Xu, XiaoWei, Roth, David B.
Publicado 2020

The RAG2 C-terminus suppresses genomic instability and lymphomagenesis

por Deriano, Ludovic, Chaumeil, Julie, Coussens, Marc, Multani, Asha, Chou, YiFan, Alekseyenko, Alexander V., Chang, Sandy, Skok, Jane A., Roth, David B.
Publicado 2011

RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

por Lescale, Chloé, Abramowski, Vincent, Bedora-Faure, Marie, Murigneux, Valentine, Vera, Gabriella, Roth, David B., Revy, Patrick, de Villartay, Jean-Pierre, Deriano, Ludovic
Publicado 2016

Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing

por Hiemenz, Matthew C., Kadauke, Stephan, Lieberman, David B., Roth, David B., Zhao, Jianhua, Watt, Christopher D., Daber, Robert D., Morrissette, Jennifer J. D.
Publicado 2016

The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect

por Hewitt, Susannah L., Wong, Jason B., Lee, Ji-Hoon, Nishana, Mayilaadumveettil, Chen, Hongxi, Coussens, Marc, Arnal, Suzzette M., Blumenberg, Lili M., Roth, David B., Paull, Tanya T., Skok, Jane A.
Publicado 2017