Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions

por Skinner, Owen S., Blanco-Fernández, Joan, Goodman, Russell P., Kawakami, Akinori, Shen, Hongying, Kemény, Lajos V., Joesch-Cohen, Lena, Rees, Matthew G., Roth, Jennifer A., Fisher, David E., Mootha, Vamsi K., Jourdain, Alexis A.
Publicado 2023

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

por McFarland, James M., Paolella, Brenton R., Warren, Allison, Geiger-Schuller, Kathryn, Shibue, Tsukasa, Rothberg, Michael, Kuksenko, Olena, Colgan, William N., Jones, Andrew, Chambers, Emily, Dionne, Danielle, Bender, Samantha, Wolpin, Brian M., Ghandi, Mahmoud, Tirosh, Itay, Rozenblatt-Rosen, Orit, Roth, Jennifer A., Golub, Todd R., Regev, Aviv, Aguirre, Andrew J., Vazquez, Francisca, Tsherniak, Aviad
Publicado 2020

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

por Li, Qing, Jiang, Baishan, Guo, Jiaye, Shao, Hong, Del Priore, Isabella S., Chang, Qing, Kudo, Rei, Li, Zhiqiang, Razavi, Pedram, Liu, Bo, Boghossian, Andrew S., Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Donovan, Katherine A., Palafox, Marta, Reis-Filho, Jorge S., de Stanchina, Elisa, Fischer, Eric S., Rosen, Neal, Serra, Violeta, Koff, Andrew, Chodera, John D., Gray, Nathanael S., Chandarlapaty, Sarat
Publicado 2022

Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling

por Fan, Mengyang, Lu, Wenchao, Che, Jianwei, Kwiatkowski, Nicholas P, Gao, Yang, Seo, Hyuk-Soo, Ficarro, Scott B, Gokhale, Prafulla C, Liu, Yao, Geffken, Ezekiel A, Lakhani, Jimit, Song, Kijun, Kuljanin, Miljan, Ji, Wenzhi, Jiang, Jie, He, Zhixiang, Tse, Jason, Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Mancias, Joseph D, Marto, Jarrod A, Dhe-Paganon, Sirano, Zhang, Tinghu, Gray, Nathanael S
Publicado 2022

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

por Hofman, Damon A., Ruiz-Orera, Jorge, Yannuzzi, Ian, Murugesan, Rakesh, Brown, Adam, Clauser, Karl R., Condurat, Alexandra L., van Dinter, Jip T., Engels, Sem A.G., Goodale, Amy, van der Lugt, Jasper, Abid, Tanaz, Wang, Li, Zhou, Kevin N., Vogelzang, Jayne, Ligon, Keith L., Phoenix, Timothy N., Roth, Jennifer A., Root, David E., Hubner, Norbert, Golub, Todd R., Bandopadhayay, Pratiti, van Heesch, Sebastiaan, Prensner, John R.
Publicado 2023

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

por Abbott, Keene L., Ali, Ahmed, Casalena, Dominick, Do, Brian T., Ferreira, Raphael, Cheah, Jaime H., Soule, Christian K., Deik, Amy, Kunchok, Tenzin, Schmidt, Daniel R., Renner, Steffen, Honeder, Sophie E., Wu, Michelle, Chan, Sze Ham, Tseyang, Tenzin, Greaves, Daniel, Hsu, Peggy P., Ng, Christopher W., Zhang, Chelsea J., Farsidjani, Ali, Gramatikov, Iva Monique T., Matheson, Nicholas J., Lewis, Caroline A., Clish, Clary B., Rees, Matthew G., Roth, Jennifer A., Griner, Lesley Mathews, Muir, Alexander, Auld, Douglas S., Heiden, Matthew G. Vander
Publicado 2023

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

por Baumgartner, Christina K., Ebrahimi-Nik, Hakimeh, Iracheta-Vellve, Arvin, Hamel, Keith M., Olander, Kira E., Davis, Thomas G. R., McGuire, Kathleen A., Halvorsen, Geoff T., Avila, Omar I., Patel, Chirag H., Kim, Sarah Y., Kammula, Ashwin V., Muscato, Audrey J., Halliwill, Kyle, Geda, Prasanthi, Klinge, Kelly L., Xiong, Zhaoming, Duggan, Ryan, Mu, Liang, Yeary, Mitchell D., Patti, James C., Balon, Tyler M., Mathew, Rebecca, Backus, Carey, Kennedy, Domenick E., Chen, Angeline, Longenecker, Kenton, Klahn, Joseph T., Hrusch, Cara L., Krishnan, Navasona, Hutchins, Charles W., Dunning, Jax P., Bulic, Marinka, Tiwari, Payal, Colvin, Kayla J., Chuong, Cun Lan, Kohnle, Ian C., Rees, Matthew G., Boghossian, Andrew, Ronan, Melissa, Roth, Jennifer A., Wu, Meng-Ju, Suermondt, Juliette S. M. T., Knudsen, Nelson H., Cheruiyot, Collins K., Sen, Debattama R., Griffin, Gabriel K., Golub, Todd R., El-Bardeesy, Nabeel, Decker, Joshua H., Yang, Yi, Guffroy, Magali, Fossey, Stacey, Trusk, Patricia, Sun, Im-Meng, Liu, Yue, Qiu, Wei, Sun, Qi, Paddock, Marcia N., Farney, Elliot P., Matulenko, Mark A., Beauregard, Clay, Frost, Jennifer M., Yates, Kathleen B., Kym, Philip R., Manguso, Robert T.
Publicado 2023